Does the Increasing Trend of Colorectal Cancer Incidence in Jeddah Reflect a Rise in the Kingdom of Saudi Arabia?

Abstract

Background: The aim of this study was to outline the trend in the incidence of colorectal cancer (CRC) in the city of Jeddah, Kingdom of Saudi Arabia (KSA), for comparison with previously published national CRC data. Materials and Methods: A retrospective data analysis was performed on all cases of CRC diagnosed between January 2000 and December 2006 amongst Saudi patients in Jeddah using data retrieved from the Saudi Cancer Registry (SCR). Descriptive analysis was performed and results were compared to national CRC data from the SCR. Results: In Jeddah, 644 cases of CRC were diagnosed during the time period, accounting for 15% of all CRC cases in KSA. Males were more commonly affected than females (58% versus 42%). The male preponderance of CRC was similar to that observed at a national level. In Jeddah, the incidence was higher among those >45 years (77.0%), and the mean age at diagnosis was 57 years. At diagnosis, 10% of patients presented with localized disease; 25% presented with distant metastasis and the remaining patients had various stages of regional extension. Adenocarcinomas accounted for 72% of cases. Statistical analysis did not reveal any clinically significant differences between cases diagnosed in Jeddah and those diagnosed throughout KSA. Conclusions: The increased trend in the incidence of CRC in Jeddah between 2000 and 2006 mirrors the recent trend in KSA. This highlights the magnitude of this healthcare hazard, not only in Jeddah, but also across the country and supports the need for preventive measures and early detection of the disease.

Descriptive Epidemiology of Colorectal Cancer in University Malaya Medical Centre, 2001 to 2010

“…Similar to earlier reports, this study reiterates that a significant proportion of Malays present at younger age compared to the Chinese and Indians (King and Kutty, 1971). A recent study from Jeddah Saudi Arabia reports mean age of 58 for male and 53 for female (Mosli and Al-Ahwal, 2012) and Iran mean age of 57.7 for male and 56.6 for female (Hajmanoochehri et al, 2014). Possible explanations are yet to be unveiled.…”

A Review of the Incidence of Colorectal Cancer in the Middle East

“…It should be mentioned that several studies from different parts of Turkey reported different risk rates ranging from 7 to 16 (14,15). In Saudi Arabia, there was a steady mild increase in the risk of CRC (16)(17)(18). As shown in graph No.1, this risk was half of that of Jordan and Arab Palestinians.…”

Overview of Cancer Registration Research in the Asian Pacific from 2008-2013

“…An increased trend in the incidence of CRC in Jeddah between 2000 and 2006 mirrors the recent trend in Saudi Arabia, 25% presenting with distant metastasis and adenocarcinomas accounting for 72% of cases (Mosli and Al-Ahwal, 2012). The five-year OS for 1994-2004 was 44.6% for patients with CRC, rates by stage being generally lower than the typically reported survival rates (Al-Ahwal et al, 2013).…”