Does the microenvironment influence the cell types of origin for prostate cancer?

Goldstein, Andrew S.; Witte, Owen N.

doi:10.1101/gad.222380.113

Cited by 30 publications

(26 citation statements)

References 65 publications

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“…It is well known that complex interactions regulate immune cells in the tumor microenvironment [26][27][28][29]. Immune system cells infiltrating prostate cancer include cells associated with innate immune response i.e., macrophages [30,31], neutrophils [32], mast cells (MCs) [33][34][35], and natural killer (NK) cells [36], as well as cells associated with an adaptive immune response i.e., T-and B-lymphocytes [37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and prostate cancer: friends or foe?

Taverna

Pedretti

et al. 2015

Inflamm. Res.

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There are growing evidences that chronic inflammation is involved in the regulation of cellular events in prostate carcinogenesis, including disruption of the immune response and regulation of the tumor microenvironment. This review discusses the role played by the innate and adaptive immune system in the local progression of prostate cancer, and the prognostic information that we can currently understand and exploit.

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Section: Introductionmentioning

confidence: 99%

Inflammation and prostate cancer: friends or foe?

Taverna

Pedretti

et al. 2015

Inflamm. Res.

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“…5 In addition, the ability of inflammation to enhance basal-to-luminal differentiation in vivo 20 suggests that alteration of the tissue microenvironment could influence the cell of origin. 13 Many attempts have been made to identify the cellular origin of canine PC but remain inconclusive thus far. Within the prostatic epithelium, basal and luminal cells can be distinguished on the basis of their localization, morphology, and phenotypic features.…”

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confidence: 99%

Different Growth Patterns of Canine Prostatic Carcinoma Suggests Different Models of Tumor-Initiating Cells

Akter

Lean

et al. 2015

Vet Pathol

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Controversies remain regarding the cell type from which human prostate cancer originates, and many attempts have been made to identify the cellular origin of canine prostate cancer but without definitive proof. This study aims to evaluate the expression of luminal (androgen receptor [AR], cytokeratin [CK]8/18) and basal (CK14, CK5) cell markers in different histologic subtypes of canine prostatic carcinoma (PC) and to suggest the most likely tumor-initiating cells. Normal prostates (n ¼ 8) were characterized by ARþCK8/18þ luminal cells and few CK5þ basal cells, while CK14 was absent. Similar pattern was observed in all 35 prostates with benign prostatic hyperplasia, except few scattered CK14þ basal cells in 13 samples (37.14%). AR was localized in the nucleus of both normal and hyperplastic cells. In 34 samples of PC, the following growth patterns were identified: cribriform (44.12%), solid (32.35%), small acinar/ductal (20.59%), and micropapillary (2.94%). Most PCs expressed AR and CK8/18, while CK5 and CK14 expression was observed in 25% and 20% of cases, respectively. AR revealed a variable intracellular distribution, both nuclear and cytoplasmic. Solid PC was characterized by an undifferentiated or aberrant phenotype with a reduced expression of AR and CK8/18, increased number of CK14þ cells, and 7 antigen expression patterns. This study demonstrated a predominance of differentiated luminal cell types in canine prostatic tumors, although the role of basal cells in prostate carcinogenesis should also be considered. Moreover, few scattered CK5þ cells in ARþCK8/18þ tumors identified the existence of intermediate cells, from which neoplastic transformation may alternatively commence.

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“…7 Microcephalin is involved in the DNA-damage response and has been linked to tumor formation and cancer AGR2 is developmentally regulated initially discovered as an estrogen-responsive gene in breast cancer cell lines currently linked to tumors with poor outcome. 10 With regard to the influence of the microenvironment on cells and how changes in such microenvironments 11 could lead to phenotypic progression and cancer transformation, 12 analysis showed that alterations in external factors, such as the pH of a tissue, could trigger cellular changes 13 and regulate cell transformation. 14 An acidic environment (pH 6.5-6.9 compared with pH 7.2-7.4) could cause degradation of the extracellular matrix (ECM) and lead to the secretion of VEGF, as well as to angiogenesis, which can correlate with tumor transformation and cellular invasion ( Figure 4).…”

Section: Malignant Transformation: From a Normal To A Cancerous Phenomentioning

confidence: 99%

Current status and perspectives in atomic force microscopy-based identification of cellular transformation

Dong

Dinu

2016

IJN

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Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, as well as how the transforming potential of a tissue from a benign to a cancerous one is related to the dynamics of both the cell and its surroundings, holds promise for the development of targeted translational therapies. This review provides a comprehensive overview of atomic force microscopy-based technology and its applications for identification of cellular progression to a cancerous phenotype. The review also offers insights into the advancements that are required for the next user-controlled tool to allow for the identification of early cell transformation and thus potentially lead to improved therapeutic outcomes.

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Does the microenvironment influence the cell types of origin for prostate cancer?

Cited by 30 publications

References 65 publications

Inflammation and prostate cancer: friends or foe?

Inflammation and prostate cancer: friends or foe?

Different Growth Patterns of Canine Prostatic Carcinoma Suggests Different Models of Tumor-Initiating Cells

Current status and perspectives in atomic force microscopy-based identification of cellular transformation

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