Does the plasma level of vitamins A and E affect acne condition?

El-Akawi, Zeyad; Abdel-Latif, N.; Abdul‐Razzak, Khalid K.

doi:10.1111/j.1365-2230.2006.02106.x

Cited by 50 publications

(43 citation statements)

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“…Additionally the antibiotics are becoming less and less useful as resistant strains of P. acnes are becoming more common, and the acne will generally reappear relatively soon after the end of treatment, days later in the case of topical applications, and weeks later in the case of oral antibiotics. Other less wellestablished procedures include the use of hormonal treatments (cortisone), topical or oral retinoid use (vitamin A-related compounds [6]) and phototherapy [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

et al. 2011

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“…Since the blood concentration of β-CRX has been reported to be higher than that of β-carotene or lycopene [47], it is suggested that β-CRX is easily absorbed and accumulated in the skin, where it may behave as Vitamin A for the control of cutaneous functions. Taken together with a report of El-Akawi et al [28] that low plasma levels of Vitamin A are associated with acne development and aggravation, therefore, the supplementation of β-CRX is likely to be effective for the prevention of acne or acne maintenance.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, epidemiologic studies have shown that higher intakes or blood levels of β-CRX result in a reduced risk of lung cancer and rheumatoid arthritis development [25][26][27]. On the other hand, it has also been reported that low plasma level of Vitamin A is associated with the development and aggravation of acne [28]. In addition, β-CRX is a vitamin A precursor, which is oxidatively cleaved to vitamin A by β-carotene 15,15'-dioxygenase [29], and can be stably stored in some tissue for several months [30].…”

Section: Introductionmentioning

confidence: 99%

Suppression of Sebum Production and Accumulation by <i>β</i>-Cryptoxanthin Due to the Inhibition of the Expression of Diacylglycerol Acyltransferase-1 and Perilipin in Hamster Sebocytes

Sato¹,

Shirakura²,

Mukai³

et al. 2013

JCDSA

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Background: Acne vulgaris is characterized by the enhancement of sebaceous lipogenesis and sebum secretion, and apart from retinoids and some natural products there are few effective anti-acne agents that directly suppress sebum production and accumulation in sebaceous glands. Objective: We examined the effects of β-cryptoxanthin (β-CRX), which is a carotenoid pigment most abundant in Citrus unshiu Marcovich (Satsuma mandarin orange) and plays a role as a Vitamin A precursor on sebum production and accumulation in hamster sebaceous gland cells (sebocytes). Materials and methods: The regulation of sebum production was examined by the measurement of triacylglycerols (TGs), the major sebum component, and oil red O staining in insulin-differentiated hamster sebocytes. The expression of diacylglycerol acyltransferase-1 (DGAT-1), a rate-limiting enzyme of TG biosynthesis, and perilipin 1 (PLIN1), a lipid storage droplet protein, was analyzed using real-time PCR and Western blotting. Results: Hamster sebocytes constitutively produced TGs during cultivation and the production of TGs was enhanced by insulin treatment. Both constitutive and insulin-enhanced TG productions were dose-and time-dependently inhibited by β-CRX as well as 13-cis retinoic acid. In addition, the gene expression of DGAT-1 was suppressed by β-CRX in the sebocytes. Furthermore, the insulin-enhanced sebum accumulation as lipid droplets was reduced in the β-CRX-treated cells. Moreover, β-CRX was found to suppress the gene expression and production of PLIN1 in insulin-differentiated hamster sebocytes. Conclusions: These results provide novel evidence that β-CRX is an effective candidate for acne therapy by its ability to exert dual inhibitory actions against DGAT-1-dependent TG production and PLIN1-mediated lipid-droplet formation in hamster sebocytes.

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“…There are many common treatments for acne lesions including drugs, over the counter products and procedures such as laser therapy [2–4]. There has also been an increasing interest in the use of natural products for skin health such as vitamin C, other antioxidants, botanicals and omega-3 fatty acids [5, 6]. One agent that has shown promise in reducing facial acne lesions is pantothenic acid (vitamin B 5 ).…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne

Yang

Moclair

Hatcher

et al. 2014

Dermatol Ther (Heidelb)

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IntroductionThe purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions.MethodsA randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were randomized to the study agent, a pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint). The primary outcome of the study was the difference in total lesion count between the study agent group versus the placebo group from baseline to endpoint. Secondary measurements included differences in mean non-inflammatory and inflammatory lesions, Investigators Global Assessment and Dermatology Life Quality Index (DLQI) scores between the two groups. Investigator assessment of overall improvement and skin photographs were also taken. Safety and tolerability endpoints were the assessment of adverse events and measurement of serum complete blood count and hepatic function.ResultsForty-eight subjects were enrolled and 41 were evaluable. There was a significant mean reduction in total lesion count in the pantothenic acid group versus placebo at week 12 (P = 0.0197). Mean reduction in inflammatory lesions was also significantly reduced and DLQI scores were significantly lower at week 12 in the pantothenic acid group versus placebo. The study agent was safe and well tolerated.ConclusionsThe results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes. Further randomized, placebo-controlled trials are warranted.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0052-3) contains supplementary material, which is available to authorized users.

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Does the plasma level of vitamins A and E affect acne condition?

Abstract: Based on our results, we conclude that low vitamin A and E plasma levels have an important role in the pathogenesis of acne and in the aggravation of this condition.

Cited by 50 publications

References 19 publications

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

Suppression of Sebum Production and Accumulation by <i>β</i>-Cryptoxanthin Due to the Inhibition of the Expression of Diacylglycerol Acyltransferase-1 and Perilipin in Hamster Sebocytes

A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne

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Does the plasma level of vitamins A and E affect acne condition?

Abstract: Based on our results, we conclude that low vitamin A and E plasma levels have an important role in the pathogenesis of acne and in the aggravation of this condition.

Cited by 50 publications

References 19 publications

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes

Suppression of Sebum Production and Accumulation by &lt;i&gt;β&lt;/i&gt;-Cryptoxanthin Due to the Inhibition of the Expression of Diacylglycerol Acyltransferase-1 and Perilipin in Hamster Sebocytes

A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne

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Suppression of Sebum Production and Accumulation by <i>β</i>-Cryptoxanthin Due to the Inhibition of the Expression of Diacylglycerol Acyltransferase-1 and Perilipin in Hamster Sebocytes