Does the Rate of Rewarming from Profound Hypothermic Arrest Influence the Outcome in a Swine Model of Lethal Hemorrhage?

Alam, Hasan B.; Rhee, Peter; Honma, Kaneatsu; Chen, Huazhen; Ayuste, Eduardo C.; Lin, Tom K.; Toruno, Kevin; Mehrani, Tina; Engel, Caroline; Chen, Zheng; Gentilello, Larry M.; Long, William B.; Moore, Frederick A.; Pitt, Lawrence H.

doi:10.1097/01.ta.0000198469.95292.ec

Cited by 89 publications

(60 citation statements)

References 49 publications

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“…A hypothermic cardiac arrest offers the possibility of survival because of the effects of rapid cooling. Hypothermia causes a decrease in cellular oxygen demand, which is advantageous during periods of ischemia [15]. Cardiac surgeons take advantage of controlled hypothermia to perform surgery under circulatory arrest.…”

Section: Discussionmentioning

confidence: 99%

Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz

Meneghini

Ferreira²,

Abreu

et al. 2008

Rev Bras Cir Cardiovasc

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Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz AbstractIntroduction: Total body induced hypothermia and myocardial cooling are effective methods regarding myocardial protection during heart surgery and ischemia. It is described in previous studies that extreme low temperature exposure causes mitochondrial cristae and myofilament disarrangement in cardiomyocytes, however, no investigation has analyzed the effects of cold stress on nuclear size of cardiomyocytes.Objectives: To evaluate the effects of acute cold stress exposure on the nuclear size of cardiomyocytes in rats.Methods: The experimental study procedures were 531MENEGHINI, A ET AL -Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz Rev Bras Cir Cardiovasc 2008; 23(4): 530-533

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Section: Discussionmentioning

confidence: 99%

Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz

Meneghini

Ferreira²,

Abreu

et al. 2008

Rev Bras Cir Cardiovasc

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show abstract

“…A hypothermic cardiac arrest offers the possibility of survival because of the effects of rapid cooling. Hypothermia causes a decrease in cellular oxygen demand, which is advantageous during periods of ischemia [9]. Cardiac surgeons take advantage of controlled hypothermia to perform surgery under circulatory arrest.…”

Section: Discussionmentioning

confidence: 99%

An established extracorporeal membrane oxygenation protocol promotes survival in extreme hypothermia

Scaife

Connors

Morris

et al. 2007

Journal of Pediatric Surgery

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“…More importantly, they showed that profound hypothermia could be used successfully, even after 60 min of normothermic shock, and that the surviving animals were not only neurologically intact but also had normal cognitive functions. Subsequent studies showed that the best outcomes were achieved using rapid induction of hypothermia (2 °C/min) and a slower rate of reversal (0.5 °C/min warming) [70,86]. Moreover, these studies using Unisol solutions for implementing HBS demonstrated the preservation of various cell types in the central nervous system, in addition to providing some immunological advantages [87,88].…”

Section: Recent Advances Using a Pre-clinical Porcine Hemorrhagic Shomentioning

confidence: 99%

Hypothermic Blood Substitution: Special Considerations for Protection of Cells during ex vivo and in vivo Preservation

Taylor¹

2007

Transfus Med Hemother

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Clinical applications of hypothermia range from ex vivo storage of cells, tissues and organs for transplantation or cell-based therapies to in vivo protection of a patient during complex surgeries that might entail circulatory and/or cardiac arrest. The intent of this brief review is to outline the essential principles of hypothermia applied in the preservation of cells for a multitude of clinical purposes. The focus will be confined to our ability as interventionalists to control the environment of cells to optimize hypothermic preservation. More specifically, this review will summarize the design principles of hypothermic blood substitutes (HBS) defined as preservation solutions for protection of cells, tissues and organs during a hypothermic preservation interval. In contrast to the types of solutions that have been used historically as hemodiluents for clinical hypothermia, i.e. normal physiologically balanced salt solutions, our approach has been to design aqueous blood substitutes that embody many of the principles now identified as contributory and important for optimal ex vivo organ preservation. The working hypothesis that we have addressed using a variety of pre-clinical large animal models is that acellular solutions can be designed to act as universal tissue preservation solutions during several hours of hypothermic whole-body washout involving cardiac arrest, with or without circulatory arrest. On this basis, two new types of solutions, designated ‘Purge’ and ‘Maintenance’ HBS, have been formulated and evaluated to fulfill separate requirements during the asanguineous procedure. The evidence supporting this concept is reviewed in the context of imminent clinical trials to apply this novel technique for the preservation and resuscitation of trauma victims suffering hemorrhagic shock.

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Does the Rate of Rewarming from Profound Hypothermic Arrest Influence the Outcome in a Swine Model of Lethal Hemorrhage?

Abstract: Rapid induction of hypothermic arrest maintains viability of brain during repair of lethal vascular injuries. Long-term survival is influenced by the rate of reversal of hypothermia.

Cited by 89 publications

References 49 publications

Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz

Efeitos do estresse pelo frio sobre o tamanho nuclear do cardiomiócito em ratos: avaliação por microscopia de luz

An established extracorporeal membrane oxygenation protocol promotes survival in extreme hypothermia

Hypothermic Blood Substitution: Special Considerations for Protection of Cells during ex vivo and in vivo Preservation

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