Does the use of acetylsalicylic acid have an influence on our vision?

Michalska-Małecka, Katarzyna; Regucka, Agnieszka; Śpiewak, Dorota; Sosnowska-Pońska, Magdalena; Niewiem, Alfred

doi:10.2147/cia.s115234

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…ASA, commonly known as aspirin, is a small-molecule drug that sees globally prevalent usage due to its analgesic, anti-inflammatory and antipyretic properties ( Michalska-Małecka et al, 2016 ). ASA is a member of the nonsteroidal anti-inflammatory drugs (NSAIDs) class, which inhibit the cyclooxygenase (COX) enzyme.…”

Section: Ddss With Switches—controlled By Lightmentioning

confidence: 99%

Molecular Switches—Tools for Imparting Control in Drug Delivery Systems

2022

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Cancer is a globally prevalent cause of premature mortality. Of growing interest is the development of novel anticancer therapies and the optimisation of associated risks. Major issues presently facing conventional anticancer therapies include systemic toxicity, poor solubility, membrane permeability, and multidrug resistance Nanocarriers have been employed to address these issues. Nanocarriers encapsulate anticancer drugs, enabling them to bypass biological barriers and minimise their adverse side effects. These drug delivery systems offer extensive benefits as they can be modified to gravitate towards specific environmental conditions. To further enhance the safety and efficacy of these drug carriers, modern developments have included incorporating a molecular switching mechanism into their structure. These molecular switches are responsive to endogenous and exogenous stimuli and may undergo reversible and repeatable conformational changes when activated. The incorporation of molecular switches can, therefore, impart stimuli-responsive drug-release control on a DDS. These stimuli can then be manipulated to offer precise dosage control over the drug release at a specific target site. This review discusses recent developments in the design of DDSs incorporating light and pH-responsive molecular switches as drug release controllers.

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Section: Ddss With Switches—controlled By Lightmentioning

confidence: 99%

Molecular Switches—Tools for Imparting Control in Drug Delivery Systems

2022

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“…As we all know, aspirin (Asp), which is the classic drug in the history of medicine, exerts a very significant therapeutic effect on inflammation ( Michalska-Małecka et al, 2016 ). However, the gastrointestinal side effects of Asp limit its application.…”

Section: Introductionmentioning

confidence: 99%

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice

Liu,

Tao,

Shen

et al. 2023

Front. Pharmacol.

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Introduction: Inflammation is a defensive response of the body and the pathological basis of many diseases. However, excessive inflammation and chronic inflammation impair the homeostasis of the organism. Arachidonic acid (AA) has a close relationship with inflammation and is the main mediator of the pro-inflammatory response. Based on the prodrug principle, the new pharmaceutical compound aspirin eugenol ester (AEE) was designed and synthesized. However, the effects of AEE on key enzymes, metabolites and inflammatory signaling pathways in the AA metabolic network have not been reported.Methods: In this study, the anti-inflammation effects of AEE were first investigated in mice and RAW264.7 cells in LPS induced inflammation model. Then, the changes of the key enzymes and AA metabolites were explored by RT-PCR and targeted metabolomics. Moreover, the regulatory effects on NF–kB and MAPKS signaling pathways were explored by Western Blotting.Results: Results indicated that AEE significantly reduced the number of leukocyte and increased the lymphocyte percentage. AEE decreased the expression levels of IL-1β, IL-6, IL-8 and TNF-α both in vivo and in vitro. In the liver of mice, AEE downregulated the levels of AA, prostaglandin D2 (PGD2) and upregulated 12- hydroxyeicosatetraenoic acid (12-HETE). However, the changes of PGE2, PGF2α, 6-keto-prostaglandin F1α (6-KETO-PGF1α), 9-hydroxy-octadecenoic acid (9- HODE), 13-HODE, 15-HETE, docosahexaenoic acid (DHA) and thromboxane B2 (TXB2) were not significant. Additionally, it was found that AEE decreased the relative mRNA expression levels of p65 and p38 and the ratio of p-p65/p65.Discussion: It was concluded that AEE might inhibit the LPS-induced inflammatory response through the regulation of AA metabolism. This study provides the theoretical foundation for the development of AEE as a medicinal anti-inflammatory drug.

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Analgesics, Narcotic Antagonists, and Drugs Used to Treat Arthritis

Fraunfelder

2021

Drug-Induced Ocular Side Effects

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Does the use of acetylsalicylic acid have an influence on our vision?

Cited by 4 publications

References 37 publications

Molecular Switches—Tools for Imparting Control in Drug Delivery Systems

Molecular Switches—Tools for Imparting Control in Drug Delivery Systems

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice

Analgesics, Narcotic Antagonists, and Drugs Used to Treat Arthritis

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