Does the use of Vicryl™ Plus Antibacterial Suture Decrease the Incidence of Umbilical Infection When Compared to Vicryl™ Suture?

DeFazio, A.; Datta, Meghna; Nezhat, Camran

doi:10.1016/j.fertnstert.2005.07.395

Cited by 9 publications

(23 citation statements)

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“…Several meta‐analyses have been conducted with varying included studies ( Table ). These differences cannot be explained by publication date only.…”

Section: Resultsmentioning

confidence: 99%

“…Study characteristics are listed in Table . Of the 21 RCTs, 15 were single‐centre trials, five were multicentre trials and one abstract did not report on single‐centre or multicentre character. In the final analysis a total of 3208 patients were randomized to TCS and 3254 to standard sutures without triclosan coating.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, one study included patients undergoing head and neck surgery, one included pilonidal cyst surgery and seven studies included patients undergoing an abdominal operation. Five studies included both clean and non‐clean procedures, of which two included a variety of procedures, two included abdominal procedures and one umbilical trocar incisions after laparoscopy. Of these, three reported SSI for clean and non‐clean procedures separately; the other two were classified as non‐clean.…”

Section: Resultsmentioning

confidence: 99%

“…RCTs have been conducted to investigate its effect on SSI in various surgical procedures and with different types of suture. Several meta‐analyses have been published showing different results, but also a wide variety in study and data selection ( Table ). None of these previously published meta‐analyses used meta‐regression to substantiate subgroup effects and assess generalizability of the overall effect across subgroups.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis and trial sequential analysis of triclosan-coated sutures for the prevention of surgical-site infection

Jonge

Atema

Solomkin

et al. 2017

British Journal of Surgery

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Background: Triclosan-coated sutures (TCS) were developed to reduce the risk of surgical-site infection (SSI). Level 1A evidence of effectiveness has been presented in various recent meta-analyses, yet well designed RCTs have not been able to reproduce these favourable results. The aim of this study was to evaluate all available evidence critically with comprehensive analysis to seek a more reliable answer regarding the effectiveness of TCS in the prevention of SSI.Methods: PubMed, MEDLINE, Embase and Cochrane Library databases were searched from 1990 to November 2015 for RCTs that compared TCS with sutures that were exactly the same, but uncoated, in the prevention of SSI. Pooled relative risks (RRs) with corresponding 95 per cent confidence intervals were estimated using a random-effects model. Metaregression was used to substantiate subgroup effects, trial sequential analysis was employed to assess the risk of random error, and quality of evidence was determined using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Conclusion: GRADE assessment shows moderate-quality evidence that TCS are effective in reducing SSI. Trial sequential analysis indicates that the effect was robust, and additional data are unlikely to alter the summary effect.

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“…Several meta‐analyses have been conducted with varying included studies ( Table ). These differences cannot be explained by publication date only.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meta-analysis and trial sequential analysis of triclosan-coated sutures for the prevention of surgical-site infection

Jonge

Atema

Solomkin

et al. 2017

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Seven RCTs were included in the final analysis, which included 2 unpublished trials. 24,[29][30][31][32][33][34] Records idenƟfied through database searching (n = 407)…”

Section: Trial Flowmentioning

confidence: 99%