Does the viral subtype influence the biennial cycle of respiratory syncytial virus?

Mlinarić‐Galinović, Gordana; Vojnović, Gordana; Čepin-Bogović, Jasna; Baće, Ana; Božikov, Jadranka; Welliver, Robert C.; Wahn, Ulrich; Cebalo, Ljiljana

doi:10.1186/1743-422x-6-133

Cited by 22 publications

(33 citation statements)

References 19 publications

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“…These results are consistent with the findings of others that RSV-A is not more severe than RSV-B. 44 We used real-time RT-PCR to quantitate the amount of human 18s RNA in nasal samples to overcome variability between patient respiratory specimens. We found that this reduced the amount of variation in viral load estimations and reduced the apparent differences between severity groups observed by Buckingham et al 45 and agree with Gueudin et al 46 who also normalized their samples for cell number.…”

Section: Discussionsupporting

confidence: 90%

The Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infections in Children Less than 5 Years of Age in Indonesia

Simões¹,

Mutyara²,

Soh³

et al. 2011

Pediatric Infectious Disease Journal

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Section: Discussionsupporting

confidence: 90%

The Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infections in Children Less than 5 Years of Age in Indonesia

Simões¹,

Mutyara²,

Soh³

et al. 2011

Pediatric Infectious Disease Journal

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“…This study reports predominance of RSV Group B infection in children hospitalized with CAP, which is not unusual in other regions [9,28]. Unfortunately, our data presents some limitation since we could collect samples for only one year and annual RSV Group epidemic may change.…”

Section: Discussionmentioning

confidence: 85%

Prevalence and clinical features of respiratory syncytial virus in children hospitalized for community-acquired pneumonia in northern Brazil

et al. 2012

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BackgroundChildhood pneumonia and bronchiolitis is a leading cause of illness and death in young children worldwide with Respiratory Syncytial Virus (RSV) as the main viral cause. RSV has been associated with annual respiratory disease outbreaks and bacterial co-infection has also been reported. This study is the first RSV epidemiological study in young children hospitalized with community-acquired pneumonia (CAP) in Belém city, Pará (Northern Brazil).MethodsWith the objective of determining the prevalence of RSV infection and evaluating the patients’ clinical and epidemiological features, we conducted a prospective study across eight hospitals from November 2006 to October 2007. In this study, 1,050 nasopharyngeal aspirate samples were obtained from hospitalized children up to the age of three years with CAP, and tested for RSV antigen by direct immunofluorescence assay and by Reverse Transcription Polymerase Chain Reaction (RT-PCR) for RSV Group identification.ResultsRSV infection was detected in 243 (23.1%) children. The mean age of the RSV-positive group was lower than the RSV-negative group (12.1 months vs 15.5 months, p<0.001) whereas gender distribution was similar. The RSV-positive group showed lower means of C-reactive protein (CRP) in comparison to the RSV-negative group (15.3 vs 24.0 mg/dL, p<0.05). Radiological findings showed that 54.2% of RSV-positive group and 50.3% of RSV-negative group had interstitial infiltrate. Bacterial infection was identified predominantly in the RSV-positive group (10% vs 4.5%, p<0.05). Rhinorrhea and nasal obstruction were predominantly observed in the RSV-positive group. A co-circulation of RSV Groups A and B was identified, with a predominance of Group B (209/227). Multivariate analysis revealed that age under 1 year (p<0.015), CRP levels under 48 mg/dL (p<0.001) and bacterial co-infection (p<0.032) were independently associated with the presence of RSV and, in the analyze of symptoms, nasal obstruction were independently associated with RSV-positive group (p<0.001).ConclusionThe present study highlights the relevance of RSV infection in hospitalized cases of CAP in our region; our findings warrant the conduct of further investigations which can help design strategies for controlling the disease.

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“…Infections manifest as mild upper respiratory tract infections (URTI) or lower respiratory tract infections (LRTI), including bronchitis, bronchiolitis, and pneumonia 1–3 . A multi‐year epidemiological study of RSV infections in Croatia has shown that RSV infections have a repeated biennial pattern 4,5 . After a major RSV outbreak beginning in December/January (1994/95, 1996/97, 1998/99, 2000/01, 2002/03, 2004/05 and 2006/07), there ensues a minor one beginning 14–16 months later (March/April peak of 1996, 1998, 2000, 2002, 2004 and 2006), followed again by a major outbreak in another 8–10 months 4–6 .…”

mentioning

confidence: 99%

“…A multi‐year epidemiological study of RSV infections in Croatia has shown that RSV infections have a repeated biennial pattern 4,5 . After a major RSV outbreak beginning in December/January (1994/95, 1996/97, 1998/99, 2000/01, 2002/03, 2004/05 and 2006/07), there ensues a minor one beginning 14–16 months later (March/April peak of 1996, 1998, 2000, 2002, 2004 and 2006), followed again by a major outbreak in another 8–10 months 4–6 . The same biennial pattern of RSV outbreaks was also noted in Germany, Switzerland, Austria, Finland and Sweden 7–12 .…”

mentioning

confidence: 99%

Analysis of biennial outbreak pattern of respiratory syncytial virus according to subtype (A and B) in the Zagreb region

Mlinarić‐Galinović¹,

Tabain²,

Kukovec³

et al. 2012

Pediatrics International

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Does the viral subtype influence the biennial cycle of respiratory syncytial virus?

Cited by 22 publications

References 19 publications

The Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infections in Children Less than 5 Years of Age in Indonesia

The Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infections in Children Less than 5 Years of Age in Indonesia

Prevalence and clinical features of respiratory syncytial virus in children hospitalized for community-acquired pneumonia in northern Brazil

Analysis of biennial outbreak pattern of respiratory syncytial virus according to subtype (A and B) in the Zagreb region

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