Does Thrombosis Cause Intravascular Fasciitis?

Sugaya, Makoto; Tamaki, Kunihiko

doi:10.2340/00015555-0268

Cited by 12 publications

(14 citation statements)

References 11 publications

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“…Since this initial description, several additional cases have been reported [2][3][4][5][6][7][8][9][10][11][12], including three within the oral cavity [3,5] and two within periocular soft tissue [6]. With these additional reported cases, both the head and neck region and upper extremities are now the most commonly involved anatomic locations.…”

Section: Introductionmentioning

confidence: 99%

“…Immunohistochemical stains showed the spindle cells to be typically positive for smooth muscle actin and vimentin and negative for cytokeratins, S-100 protein, desmin, CD31, and CD34 [4,7,9,10,12]. Despite lacking reactivity among the spindle cells, immunostains for CD31 and CD34 could be useful to demonstrate the highly vascular stromal background and the vascular location of the lesion [10].…”

Section: Review Of the Literaturementioning

confidence: 99%

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Intravascular Fasciitis: Report of an Intraoral Case and Review of the Literature

Angela

Dunlap

Richardson

et al. 2011

Head and Neck Pathol

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Intravascular fasciitis (IF) is an unusual variant of nodular fasciitis. It is characterized by intraluminal, intramural, and extramural involvement of small to large arteries or veins. Only three cases involving the oral cavity have been reported previously in the literature. Here we present an additional case of oral IF arising in the submucosa of the upper lip of a 20-year old female. Microscopic examination showed a well-circumscribed, nodular proliferation of spindle cells arranged in intersecting fascicles. Occasional multinucleated giants cells also were noted. The tumor was present within the lumen of an intermediate-sized artery and extended into adjacent smaller vessels, thereby creating a multinodular appearance. Extramural extension into the surrounding connective tissue also was observed. Among the 31 cases of IF reported thus far (including the present case), the majority (n = 23) arose in individuals in the 1st through 3rd decades, with a 1.4:1 male:female ratio. The most common sites of involvement were the head and neck (n = 11) and upper extremity (n = 11), followed by the lower extremity (n = 6) and trunk (n = 3). Conservative excision is standard treatment, although local recurrence has been reported in three cases. It is important for the pathologist to be aware of this lesion in order to avoid misdiagnosis as a sarcoma with angioinvasion.

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Section: Introductionmentioning

confidence: 99%

Section: Review Of the Literaturementioning

confidence: 99%

Intravascular Fasciitis: Report of an Intraoral Case and Review of the Literature

Angela

Dunlap

Richardson

et al. 2011

Head and Neck Pathol

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“…The patients were generally healthy prior to the onset of the lesion. Possible predisposing factors including preceding trauma, thrombosis, and pregnancy-related hormonal changes were noted in a few cases [1,9,10]. The most common locations of the lesion are the upper extremities, head and neck, followed by the lower extremities and trunk.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on the numbers of blood vessels involved and the longitudinal extension of the lesion, the mass exhibited a single or multi-nodular appearance. In two cases, organizing thrombi were found within the lesion [1,10]. One feature that easily mimics a sarcoma is the infiltrating growth.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, two patients developed the lesion following trauma [1,5]. Organizing thrombi were found in two cases [1,10]. The occurrence of intravascular fasciitis in a 16-week pregnant woman, and a previous report showing weak expression of estrogen receptor in nodular fasciitis, led the authors to propose that pregnancy-related estrogen changes might be a predisposing factor [9].…”

Section: Discussionmentioning

confidence: 99%

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Intravascular fasciitis involving the flank of a 21-year-old female: a case report and review of the literature

2014

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BackgroundIntravascular fasciitis is an uncommon variant of nodular fasciitis, which is a reactive proliferative lesion of myofibroblasts. Since its identification in 1981, only 32 cases of intravascular fasciitis have been reported in the English literature. The lesion is commonly located in the head, neck, and extremities, with only three cases arising from the trunk. Here we report the fourth case involving the trunk (the flank area).Case presentationA 21-year-old African-American female presented with a subcutaneous mass on her flank. Grossly, the mass was red-tan, oval, and well-demarcated, measuring approximately 0.5 cm in diameter. Microscopically, the mass was composed of spindle cells arranged in a swirling and intersecting pattern inside the lumens of two blood vessels. It extended through the vascular walls into the surrounding fibroadipose tissue; in some sections, the spindle cells were intermixed with the perivascular fibrous tissue. Elastin stain revealed remnants of elastic lamina partially surrounding the lesion. The nuclei of the spindle cells were relatively uniform with tapered ends and prominent nucleoli. No significant mitotic activity was observed. Multinucleated giant cells were scattered among the spindle cells, along with infiltrating lymphocytes and extravasated red blood cells. Immunohistochemical stains showed the spindle cells were positive for smooth muscle actin, focally positive for muscle specific actin, and negative for S-100, confirming their myofibroblastic differentiation. The overall morphological and immunohistochemical features are consistent with intravascular fasciitis.ConclusionBy reporting this rare case, we would like to raise the awareness of this non-neoplastic lesion to avoid misdiagnosing it as a sarcoma with vascular invasion. Previously reported similar cases were also reviewed and compared with this case.

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Intravascular fasciitis of the scalp as a complication of ICP monitor placement: a case report and review of the literature

Tankam,

Stoltzfus,

Tachie-Baffour

et al. 2023

Childs Nerv Syst

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Does Thrombosis Cause Intravascular Fasciitis?

Cited by 12 publications

References 11 publications

Intravascular Fasciitis: Report of an Intraoral Case and Review of the Literature

Intravascular Fasciitis: Report of an Intraoral Case and Review of the Literature

Intravascular fasciitis involving the flank of a 21-year-old female: a case report and review of the literature

Intravascular fasciitis of the scalp as a complication of ICP monitor placement: a case report and review of the literature

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