Does trans-spinal direct current stimulation modulate the Hoffmann reflexes of healthy individuals? A systematic review and meta-analysisc

Albuquerque, Plínio Luna de; Mendonça, Thyciane; Campêlo, Mayara; Shirahige, Lívia; Monte-Silva, Kátia

doi:10.1038/s41393-018-0149-0

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…tsDCS, a promising noninvasive stimulation of central nervous system through a direct current over the spinal cord, emerged as an innovative tool [202]. In healthy individuals, although still debatable [203], tsDCS have been suggested to modulate spinal networks [204, 205]. Therefore, it is expected that tsDCS, modulates spinal function, and motor outcomes in subjects with SCI.…”

Section: Tdcs As a Motor Neurorehabilitation Tool In Neurological Dismentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

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117

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Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

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Section: Tdcs As a Motor Neurorehabilitation Tool In Neurological Dismentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

Self Cite

117

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“…tDCS over the motor cortex has shown variable electrophysiological and behavioural effects and there is still no general consensus about its usefulness as a therapeutic technique for rehabilitation (Buch et al, 2017;Huang et al, 2017;Rothwell, 2016;Terranova et al, 2018). From the relatively few published studies on tsDCS in human participants a similar lack of consistency appears to be present at least in the case of electrophysiological measures such as MEPs and H-reflexes (Albuquerque et al, 2018;Bocci, Barloscio, et al, 2015;Bocci, Caleo, et al, 2015;Bocci, Marceglia, et al, 2015). In the present study, clear increases in MEP and in ballistic plantar flexion were observed in some participants, whereas in others, only modest or no effects were observed.…”

Section: Variability Of Effectsmentioning

confidence: 99%

“…Despite this, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) of the primary motor cortex have been shown consistently to be facilitated by cathodal tsDCS and diminished by anodal tsDCS over the spinal segments where the motor neurons of the investigated muscle are located (Bocci, Barloscio, et al, 2015;Bocci, Marceglia, et al, 2015;Knikou, Dixon, Santora, & Ibrahim, 2015). Significantly, in the majority of studies a failure to demonstrate any changes in H-reflexes, which, at least in part, probes the excitability of the spinal motor neurons has been reported (Albuquerque, Mendonca, Campelo, Shirahige, & Monte-Silva, 2018). This suggests somewhat surprisingly that the functional effect of tsDCS is not necessarily related to effects on spinal motor neurons and interneurons locally, but may rather be related to a facilitation of corticospinal drive through increased excitability of corticospinal neurons.…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans

et al. 2020

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Optimization of motor performance is of importance in daily life, in relation to recovery following injury as well as for elite sports performance. The present study investigated whether transcutaneous spinal direct current stimulation (tsDCS) may enhance voluntary ballistic activation of ankle muscles and descending activation of spinal motor neurons in able‐bodied adults. Forty‐one adults (21 men; 24.0 ± 3.2 years) participated in the study. The effect of tsDCS on ballistic motor performance and plantar flexor muscle activation was assessed in a double‐blinded sham‐controlled cross‐over experiment. In separate experiments, the underlying changes in excitability of corticospinal and spinal pathways were probed by evaluating soleus (SOL) motor evoked potentials (MEPs) following single‐pulse transcranial magnetic stimulation (TMS) over the primary motor cortex, SOL H‐reflexes elicited by tibial nerve stimulation and TMS‐conditioning of SOL H‐reflexes. Measures were obtained before and after cathodal tsDCS over the thoracic spine (T11‐T12) for 10 min at 2.5 mA. We found that cathodal tsDCS transiently facilitated peak acceleration in the ballistic motor task compared to sham tsDCS. Following tsDCS, SOL MEPs were increased without changes in H‐reflex amplitudes. The short‐latency facilitation of the H‐reflex by subthreshold TMS, which is assumed to be mediated by the fast conducting monosynaptic corticomotoneuronal pathway, was also enhanced by tsDCS. We argue that tsDCS briefly facilitates voluntary motor output by increasing descending drive from corticospinal neurones to spinal plantar flexor motor neurons. tsDCS can thus transiently promote within‐session CNS function and voluntary motor output and holds potential as a technique in the rehabilitation of motor function following central nervous lesions.

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“…Mainly, the soleus H-reflex becomes excited by cathodal tsDCS and depressed by anodal tsDCS, resulting in homosynaptic depression. Moreover, presynaptic resistance and postactivation depression can be stimulated by tsDCS and can decrease spasticity by modulating interneuronal sensitivity [ 73 , 74 , 82 , 83 ]. In another study, Niérat et al [ 63 ] found that the cathodal part of tsDCS increases the respiratory neuromechanical element resulting in an increased tidal volume.…”

Section: Trans-spinal Direct Current Stimulation (Tsdcs)mentioning

confidence: 99%

Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review

Rahman

Tharu

Gustin

et al. 2022

JCM

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Spinal cord injury (SCI) is one of the most debilitating injuries in the world. Complications after SCI, such as respiratory issues, bowel/bladder incontinency, pressure ulcers, autonomic dysreflexia, spasticity, pain, etc., lead to immense suffering, a remarkable reduction in life expectancy, and even premature death. Traditional rehabilitations for people with SCI are often insignificant or ineffective due to the severity and complexity of the injury. However, the recent development of noninvasive electrical neuromodulation treatments to the spinal cord have shed a ray of hope for these individuals to regain some of their lost functions, a reduction in secondary complications, and an improvement in their life quality. For this review, 250 articles were screened and about 150 were included to summarize the two most promising noninvasive spinal cord electrical stimulation methods of SCI rehabilitation treatment, namely, trans-spinal direct current stimulation (tsDCS) and trans-spinal pulsed current stimulation (tsPCS). Both treatments have demonstrated good success in not only improving the sensorimotor function, but also autonomic functions. Due to the noninvasive nature and lower costs of these treatments, in the coming years, we expect these treatments to be integrated into regular rehabilitation therapies worldwide.

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Does trans-spinal direct current stimulation modulate the Hoffmann reflexes of healthy individuals? A systematic review and meta-analysisc

Abstract: tsDCS did not affect the Hoffmann reflex, as shown in six studies. However, these findings come from studies with selection, performance and detection bias, and further research is needed to examine the effect of this intervention.

Cited by 8 publications

References 38 publications

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans

Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review

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