Does transcranial direct current stimulation enhance cognitive performance in Parkinson’s disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study

Aksu, Serkan; Uslu, Atilla; İşçen, Pınar; Tülay, Emine Elif; Barham, Huzeyfe; Soyata, Ahmet Zihni; Demirtaş-Tatlıdede, Aslı; Yildiz, Gulsen Babacan; Bılgıç, Başar; Hanağası, Haşmet; Woods, Adam J.; Karamürsel, Saçit; Uyar, Fatma

doi:10.1007/s10072-022-06020-z

Cited by 15 publications

(10 citation statements)

References 97 publications

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“…There was a total of four studies that included TMT-A data. [ 19 , 20 , 22 ] The mean value for this test is time in seconds. However, in one of the studies, namely, Gomes, the unit for a time was not mentioned, and the values were in a very different range.…”

Section: Resultsmentioning

confidence: 99%

“…A total of four studies that have pre- and post-treatment scores were included in the analysis. [ 16 , 18 , 20 , 22 ] This included data from 133 participants, who underwent active tDCS and 130 participants, who underwent sham tDCS. The overall SMD (95% CI) obtained was −0.09 (−0.44, 0.25), which implied that the difference in DST-F scores was not significant among the two groups (z = 0.51; P = 061) with I2 = 42% (χ 2 = 5.18; P = 0.16) [ Figure 2c ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the studies that were selected based on the criteria, three had data for DST-B. [ 16 , 20 , 22 ] These included 64 people with MCI people in the active tDCS group and 66 people with MCI in the sham tDCS group. The pooled SMD and its 95% CI obtained overall is −0.11 (−0.54, 0.31).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies [ 16 , 18 - 24 ] were assessed using the PICO (Population, Intervention, Comparison, and Outcomes) format recommended by the Cochrane Collaboration and were found eligible to include in a meta-analysis. Hedge’s g standardized mean differences (SMDs) and its 95% confidence intervals (CIs) were calculated for MoCA, [ 19 - 21 , 23 , 24 ] MMSE, [ 16 , 21 , 24 ] TMT-A, [ 19 , 20 , 22 ] TMT-B, [ 19 , 20 ] DST-F, [ 16 , 18 , 20 , 22 ] DST-B, [ 16 , 20 , 22 ] and LMT [ 18 , 22 , 23 ] using inverse-variance-based DerSimonian and Laird’s estimation method. We used a random effects model to estimate SMDs and its CIs.…”

Section: Methodsmentioning

confidence: 99%

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Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis

Sandhya,

Malo,

Issac

2024

JNRP

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Objectives: Mild cognitive impairment (MCI) is a transition state in which individuals have cognitive abilities that are in between those of normal aging and dementia. Although not everyone with MCI develops dementia, the risk of progression to dementia is higher in people with MCI. Interventions at this stage can prevent or delay the onset of dementia. In recent years, studies on non-invasive brain stimulation techniques, namely transcranial direct current stimulation (tDCS), have gained momentum for cognitive enhancement in MCI. Since there are very few studies that also report varied results, it becomes important to analyze the effect of tDCS in MCI. The aim of this study was to systematically review the available evidence about using tDCS for MCI and to assess its efficacy using meta-analysis. Materials and Methods: Eight single- or double-blinded randomized controlled trials were included in the study. Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) for global cognition; and digit span test forward and backward, trail-making test (TMT) A and B; and logical memory test (LMT) assessing specific cognitive domains were considered. A random-effects model was used wherein the standardized mean difference (SMD) and its 95% confidence intervals were reported. Results: The effect of the active tDCS (MoCA [SMD 0.37, 95% CI −0.22–0.95], MMSE [SMD 0.26, 95% CI 0.25–0.77], TMT-A [SMD −0.01, 95% CI −0.42–0.40], and LMT [SMD 0.80, 95% CI −0.24–1.83]) when compared with the sham tDCS was statistically insignificant. Conclusion: The current meta-analysis identified insignificant improvement in cognitive performance with active tDCS treatment as compared to sham tDCS among people with MCI.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis

Sandhya,

Malo,

Issac

2024

JNRP

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“…One type of TES studied in PD is tDCS, which involves the application of a weak electrical current to the scalp to modulate cortical excitability. Studies using tDCS have reported improved motor symptoms, tremors, and gait in individuals with PD [132][133][134][135][136]. Several papers focus on the effects of tDCS on PD.…”

Section: Tes In Pdmentioning

confidence: 99%

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Yen

Lin

Chiang

2023

Life

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Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used neuroimaging techniques to review changes in brain activity. fMRI is a noninvasive technique that uses magnetic fields and radio waves to produce detailed brain images. An EEG is a noninvasive technique that records the brain’s electrical activity through electrodes placed on the scalp. This review overviews recent developments in noninvasive functional neuroimaging methods, including fMRI and EEG. Recent advances in fMRI technology, its application to studying brain function, and the impact of neuroimaging techniques on neuroscience research are discussed. Advances in EEG technology and its applications to analyzing brain function and neural oscillations are also highlighted. In addition, advanced courses in neuroimaging, such as diffusion tensor imaging (DTI) and transcranial electrical stimulation (TES), are described, along with their role in studying brain connectivity, white matter tracts, and potential treatments for schizophrenia and chronic pain. Application. The review concludes by examining neuroimaging studies of neurodevelopmental and neurological disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). We also described the role of transcranial direct current stimulation (tDCS) in ASD, ADHD, AD, and PD. Neuroimaging techniques have significantly advanced our understanding of brain function and provided essential insights into neurological disorders. However, further research into noninvasive treatments such as EEG, MRI, and TES is necessary to continue to develop new diagnostic and therapeutic strategies for neurological disorders.

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TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson’s disease: a meta-analysis

Giustiniani,

Maistrello,

Mologni

et al. 2024

Neurol Sci

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Does transcranial direct current stimulation enhance cognitive performance in Parkinson’s disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study

Cited by 15 publications

References 97 publications

Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis

Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

TMS and tDCS as potential tools for the treatment of cognitive deficits in Parkinson’s disease: a meta-analysis

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