Does transcutaneous electrical nerve stimulation (TENS) alleviate the pain experienced during bone marrow sampling in addition to standard techniques? A randomised, double-blinded, controlled trial

Tucker, David; Rockett, Mark; Hasan, Mehedi; Poplar, Sarah; Rule, Simon

doi:10.1136/jclinpath-2015-202908

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…[23] Experienced physicians are also easily able to overcome technical difficulties encountered during the procedure and are able to obtain a satisfactory sample in the first attempt, eliminating the need for multiple attempts and hence reducing overall pain. [24] However, there are studies which question this notion and advocate that the effect of physician experience and physician technique on pain intensity in BMB is minimal. [25]…”

Section: Discussionmentioning

confidence: 99%

Pain and anxiety associated with bone marrow aspiration and biopsy

Srivastava¹,

Prabhash²

2022

ijhs

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Introduction: Bone marrow biopsy (BMB) and aspiration is a fundamental part of the diagnostic workup of various benign and malignant hematological disorders. Improved via several variations and technical modifications ever since its advent in the early nineteenth century, the procedure plays a central role in establishing diagnosis in various hematological and systemic diseases.Materials and Methods: This is a prospective study conducted in the Department of Pathology, Tertiary Care Teaching Hospital over a period of 1 year. Sixty-four patients met the criteria of the study (adults aged ≥18, not having communication barrier or any kind of mental illness) and agreed to take part in the study. To gather the research data, personal information form. It is used to determine the risk group by identifying anxiety and depression, not with the aim of making a diagnosis for the patients who consult to primary care health service and have physical diseases. Anxiety before and pain during the procedure were assessed by patient interview 10 minute before and 10 minute after the procedure, respectively. A numerical rating system (NRS) scale, ranging from 0 (no symptom) to 10 (the worst), was administered to score symptom intensity.

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Section: Discussionmentioning

confidence: 99%

Pain and anxiety associated with bone marrow aspiration and biopsy

Srivastava¹,

Prabhash²

2022

ijhs

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“…Some non-pharmacological placebos can also be regarded as active placebos, closely mimicking the experience of receiving active treatment. For example, a device intervention such as transcutaneous electrical nerve stimulation (TENS) may be compared to a sham TENS, which will provide subtherapeutic levels of stimulation just above the minimal sensory threshold (Tucker 2015). Surgical placebos can be considered a more invasive form of active placebo with adverse reactions from the surgery itself and have their own ethical challenges (Wartolowska 2014).…”

Section: Description Of the Methods Being Investigatedmentioning

confidence: 99%

Active placebo versus standard placebo control interventions in pharmacological randomised trials

Laursen

Hansen

Paludan-Müller

et al. 2020

Cochrane Database of Systematic Reviews

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“…The included studies assessed eight interventions to reduce pain, including powered bone marrow biopsy system (n = 5) (Berenson et al, 2011;Bucher et al, 2013;Miller et al, 2011;Reed et al, 2011;Swords et al, 2011), distraction (n = 5) (Danhauer et al, 2010;Korkmaz & Guler, 2023;Lechtzin et al, 2010;Özdemir et al, 2019), acupoint stimulation (n = 3) (Bao et al, 2011;Sharifi Rizi et al, 2017;Shokrani et al, 2014), hypnosis (n = 2) (Katz et al, 1987, Liossi & Hatira, 1999, transcutaneous electrical nerve stimulation (TENS) (n = 1) (Tucker et al, 2015), aromatherapy (n = 1) (Abbaszadeh et al, 2018), preoperative exercise (n = 1) (Wu et al, 2015) and cognitive behavioural therapy (CBT) (n = 1) (Liossi & Hatira, 1999). participants in one study listened to music through headphones from the start to the end of the procedure (Danhauer et al, 2010), and the participants in one study listened to music through a music player from the time they went into the operating room until the end of the procedure (Özdemir et al, 2019).…”

Section: Characteristics Of Non-pharmacological Interventionsmentioning

confidence: 99%

“…In five studies (Danhauer et al, 2010;Korkmaz & Guler, 2023;Lechtzin et al, 2010;Miller et al, 2011;Özdemir et al, 2019), attrition rates exceeding 5% raised concerns about the risk of missing outcome data. Given that all studies utilized self-report scales and only three were adequately blinded (Bao et al, 2011;Miller et al, 2011;Tucker et al, 2015), bias in the measurement of outcome was assessed as 'some concerns' in the remaining 14…”

Section: Quality Assessmentmentioning

confidence: 99%

The effectiveness of non‐pharmacological interventions on reducing pain in patients undergoing bone marrow aspiration and biopsy: A systematic review and meta‐analysis of randomized controlled trials

Li,

Zhang,

Zhuang

et al. 2024

Journal of Clinical Nursing

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BackgroundPatients often consider bone marrow aspiration and biopsy to be one of the most painful medical procedures. The effectiveness of non‐pharmacological interventions to reduce pain during bone marrow aspiration and biopsy remains unclear.AimTo synthesize existing evidence regarding the effectiveness of non‐pharmacological interventions in mitigating procedural pain among patients undergoing bone marrow aspiration and biopsy.DesignA systematic review and meta‐analysis of randomized controlled trials.MethodsSix electronic databases, including PubMed, EMBASE, CINAHL, PsycINFO, Cochrane Library and Web of Science were searched from inception to July 15, 2023. The risk of bias was assessed using the Cochrane Risk of Bias Tool Version 2.0. Meta‐analysis was conducted using STATA 16. The certainty of the evidence was assessed by the GRADE approach.ResultsThis meta‐analysis included 18 studies derived from 17 articles involving a total of 1017 participants. The pooled results revealed statistically significant pain reduction effects using distraction (SMD: −.845, 95% CI: −1.344 to −.346, p < .001), powered bone marrow biopsy system (SMD: −.266, 95% CI: −.529 to −.003, p = .048), and acupoint stimulation (SMD: −1.016, 95% CI: −1.995 to −.037, p = .042) among patients undergoing bone marrow aspiration and biopsy. However, the pooled results on hypnosis (SMD: −1.228, 95% CI: −4.091 to 1.515, p = .368) showed no significant impact on pain reduction. Additionally, the pooled results for distraction did not demonstrate a significant effect on operative anxiety (MD: −2.942, 95% CI: −7.650 to 1.767, p = .221).ConclusionsDistraction, powered bone marrow biopsy system and acupoint stimulation are effective in reducing pain among patients undergoing bone marrow aspiration and biopsy.Patient or Public ContributionNot applicable.Relevance to Clinical PracticeThis meta‐analysis highlights the effectiveness of distraction, powered bone marrow biopsy system and acupoint stimulation for reducing pain in patients undergoing bone marrow biopsy. Healthcare professionals should consider integrating these interventions into pain management practices for these patients.Registration(PROSPERO): CRD42023422854.

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Does transcutaneous electrical nerve stimulation (TENS) alleviate the pain experienced during bone marrow sampling in addition to standard techniques? A randomised, double-blinded, controlled trial

Abstract: NCT02005354.

Cited by 8 publications

References 25 publications

Pain and anxiety associated with bone marrow aspiration and biopsy

Pain and anxiety associated with bone marrow aspiration and biopsy

Active placebo versus standard placebo control interventions in pharmacological randomised trials

The effectiveness of non‐pharmacological interventions on reducing pain in patients undergoing bone marrow aspiration and biopsy: A systematic review and meta‐analysis of randomized controlled trials

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