Exploring the interrelationships and influencing factors of the multifunctionality of cultivated land is crucial for achieving its multifunctional protection and sustainable use. In this paper, we take the Min River basin as a case study to construct a multifunctional evaluation system based on “agricultural production, social security, ecological service, and cultural landscape” using multi-source data. We analyze the spatial and temporal characteristics of the multifunctionality of cultivated land through kernel density estimation (KDE) and visual mapping. Subsequently, we assess the trade-off strength between the multifunctional aspects of cultivated land using the root mean square error (RMSD). Finally, we identify the drivers of the multifunctional trade-off intensity of cultivated land and analyze their influencing mechanisms using Geographic Detectors. The results show that (1) from 2010 to 2020, the multifunctional structure of cultivated land in the study area underwent significant changes: the levels of agricultural production, social security, and ecological service functions first increased and then decreased, while the levels of cultural landscape function and comprehensive function continued to increase. The spatial distribution is characterized, respectively, by “high in the east and low in the west”, “high in the west and low in the east”, “high in the north and low in the south”, “high in the whole and sporadically low in the northeast”, and “high in the middle and low in the surroundings”. (2) During the study period, the trade-off strengths related to social security functions increased, while the trade-off strengths of the remaining multifunctional pairs of cultivated land showed a weakening trend, with high values of trade-off strengths among functions particularly prominent in the Nanping Municipal District. (3) Both natural and human factors significantly affect the multifunctional trade-off strength of cultivated land. Among the specific factors, elevation, slope, average annual temperature, and per capita GDP are the key factors influencing the strength of the trade-offs between functions. The results of this study provide empirical support for enriching the understanding of the multifunctionality of cultivated land and offer a decision-making basis for promoting the differentiated management of cultivated land resources and the synergistic development of its multifunctionality.