Does UV irradiation affect polymer properties relevant to tissue engineering?

Fischbach, Claudia; Teßmar, Jörg; Lucke, Andrea; Schnell, Edith; Schmeer, Georg; Blunk, Torsten; Göpferich, Achim

doi:10.1016/s0039-6028(01)01297-3

Cited by 89 publications

(54 citation statements)

References 19 publications

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“…Electrospun PLGA and TCP containing nanocomposite scaffolds were cut into rectangles (70  10 mm , 2h) [36], the samples were placed in 250 ml simulated body fluid (SBF, pH 7.4) and incubated for 49 h at 37°C. SBF was prepared according to Kokubo et al [37] and sterile-filtered through a presterilized filter unit (Millipore, 0.22μm).…”

Section: In Vitro Biomineralization In Simulated Body Fluidmentioning

confidence: 99%

In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

et al. 2009

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In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects AbstractThe easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone.-1-

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Section: In Vitro Biomineralization In Simulated Body Fluidmentioning

confidence: 99%

In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

et al. 2009

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“…Moreover, it was shown that upon irradiation with UV light, the adhesion-suppressing properties are lost and complete removal of the PEG chains on the surface could be achieved due to cleavage of the bonds exposed to UV light on the surface of the films. [78] The superficial degradation initiated by UV light was attributed to the fact that the obtained cleaved polymer chains are highly water soluble and can therefore be eluted from the film surface.…”

Section: Pla Surface Modification With Pegmentioning

confidence: 99%

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Teßmar

Göpferich

2007

Macromolecular Bioscience

190

132

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PEG-containing copolymers play a prominent role as biomaterials for different applications ranging from drug delivery to tissue engineering. These custom-designed materials offer enormous possibilities to change the overall characteristics of biomaterials by improving their biocompatibility and solubility, as well as their ability to crystallize in polymer blends and to resist protein adsorption. This article demonstrates various principles of PEG-based material design that are applied to fine tune the properties of biomaterials for different tissue engineering applications. More specifically, strategies are described to develop PEG copolymers with various block compositions and specific bulk properties, including low melting points and improved surface hydrophilicity. Highly hydrated polymer gel networks for promoting cellular growth or suppressing protein adsorption and cell adhesion are introduced. By incorporating selectively cleavable cross-links, these hydrophilic polymers can also serve as smart hydrogel scaffolds, mimicking the natural extracellular matrix for cell cultivation and tissue growth. Ultimately, these developments lead to the creation of biomimetic materials to immobilize bioactive compounds, allowing precise control of cellular adhesion and tissue growth. [image: see text]

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“…The mechanical properties of the blends such as breaking load, elongation at break and Young's modulus are very sensitive to UV-irradiation [15]. As UV-irradiation is a good method of sterilization of biomedical materials [17], the additional aim of this work was to study the surface properties of UV-irradiated PVA films containing small amount of collagen (1%, 3% and 5%).…”

Section: Introductionmentioning

confidence: 99%