2014
DOI: 10.3390/nu6093818
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Does Vitamin C Deficiency Affect Cognitive Development and Function?

Abstract: Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences f… Show more

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Cited by 80 publications
(72 citation statements)
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References 150 publications
(209 reference statements)
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“…Canada's variety 2 killer, just behind cancer, is heart disease (Gladys Block; Ha et al, 2010;Hansen et al, 2014;Hickey and Roberts, 2007). It's the variety one cause of hospitalization and the price to the Canadian economy is staggering at $18.5 billion per year!…”
Section: Heart Disease Hindrancementioning
confidence: 99%
See 1 more Smart Citation
“…Canada's variety 2 killer, just behind cancer, is heart disease (Gladys Block; Ha et al, 2010;Hansen et al, 2014;Hickey and Roberts, 2007). It's the variety one cause of hospitalization and the price to the Canadian economy is staggering at $18.5 billion per year!…”
Section: Heart Disease Hindrancementioning
confidence: 99%
“…Aortic stiffness increases blood pressure and puts a strain on your heart. Moreover the heart frequency variability (which is an important indicator of stress of heart) is also measured (Gladys Block; Ha et al, 2010;Hansen et al, 2014;Hickey and Roberts, 2007;Kalender et al, 2010;Kunutsor et al, 2016;Marín et al, 2014;Matsuda et al, 1992;Nakata and Maeda, 2002;Nefic, 2001;Noh et al, 2005;.…”
Section: Heart Disease Hindrancementioning
confidence: 99%
“…En el cerebro en desarrollo, la densidad y la maduración neuronal se ven comprometidas por la deficiencia de vitamina C, lo que da lugar a la disminución del volumen del cerebro. 51 La deficiencia de vitamina C impacta en el metabolismo del ácido fólico y en la absorción de hierro.…”
Section: Vitamina Cunclassified
“…1 Other mechanisms have also been proposed, including antioxidant actions of vitamins and minerals on free radicals and glutamate excitotoxicity prevention. 2 We propose to evaluate for the first time, the mechanism of nootropic action of a commercial preparation of the oleoresin of Ferula spp., although few studies have addressed the research question in other ways.…”
Section: Introductionmentioning
confidence: 99%