Does vitamin D deficiency increase orthostatic hypotension risk in the elderly patients?

Soysal, Pınar; Yay, Adnan; Işık, Ahmet Turan

doi:10.1016/j.archger.2014.03.008

Cited by 40 publications

(33 citation statements)

References 26 publications

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“…After excluding 297 studies through title and abstract review, 20 full text articles were examined leading to seven studies finally retained. Five cross-sectional studies were meta-analyzed, whereas one longitudinal study was included in the descriptive analysis (Supplementary Figure 1, http://links.lww.com/HJH/A599) [19][20][21][22][23][24].…”

Section: Search Resultsmentioning

confidence: 99%

Hypovitaminosis D and orthostatic hypotension

Ometto¹,

Stubbs²,

Annweiler³

et al. 2016

Journal of Hypertension

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Section: Search Resultsmentioning

confidence: 99%

Hypovitaminosis D and orthostatic hypotension

Ometto¹,

Stubbs²,

Annweiler³

et al. 2016

Journal of Hypertension

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“…30 Considering the literature in human studies, very few authors have reported an association between hypovitaminosis D and OH. [8][9][10][11][12] Altogether these studies suggested that participants with OH had significantly lower serum 25OHD levels and that after the correction for potential confounders the association remain significant, although the number and kind of covariates included seem to be important to explain this association. 12 Whilst helpful, the cross-sectional design prevents any consideration of the directionality of this observed relationship.…”

Section: A C C E P T E D Accepted Manuscript 12mentioning

confidence: 96%

“…[8][9][10][11][12][13] Altogether, these studies showed a significant association between hypovitaminosis D and OH [8][9][10][11] , although the number and type of adjustments seems to be an important factor. 12 To the best of our knowledge, only one study has prospectively assessed the association between hypovitaminosis D and OH.…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults

Veronese

Trevisan

Bolzetta

et al. 2016

Journal of the American Society of Hypertension

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A number of small cross sectional studies have demonstrated that hypovitaminosis D (represented by low 25 hydroxyvitamin D (25OHD) levels) is associated with orthostatic hypotension (OH). We investigated if hypovitaminosis D is associated with the onset of OH in older adults over a followup of 4.4 years. 25OHD was categorized using sex specific quartiles; OH was defined as a drop of ≤20 mm Hg in systolic or ≤10 mm Hg in diastolic blood pressure <3 minutes of standing. Among 1,308 elderly without OH at baseline, using an adjusted logistic regression analysis and taking those with higher baseline serum 25OHD as reference, there was a significant increase in the onset of OH in those with lower serum 25OHD levels. The association was significant only in women when we stratified by sex. In conclusion, hypovitaminosis D predicts the onset of OH in older adults, particularly in women.

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“…Prevention strategies rely in part on the elimination of causative factors of OH. An association between OH and vitamin D deficiency (VDD) has been reported in older adults . Previous reports were limited by their cross‐sectional design, which prevented causal inferences .…”

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confidence: 99%

“…An association between OH and vitamin D deficiency (VDD) has been reported in older adults . Previous reports were limited by their cross‐sectional design, which prevented causal inferences . Because there are vitamin D receptors in blood vessel wall cells and in neurons of the baroreflex arc, which are both implicated in adaptive mechanisms to prevent OH, it was hypothesized that age‐related VDD could precipitate OH.…”

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confidence: 99%