Does vitamin D have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients?

Özuğuz, Ufuk; Oruç, Serdar; Ulu, Memnune Sena; Demirbaş, Hayri; Acay, Akif; Çoker, Beray; Beyazıt, B.; Yaman, Mehmet; Köken, Tülay

doi:10.1007/s40618-016-0509-6

Cited by 24 publications

(21 citation statements)

References 32 publications

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“…There are several potential mechanisms by which obesity could contribute to decreased vitamin D levels. Sequestration of vitamin D by adipose tissue may contribute to low circulating vitamin D concentrations in obese individuals [20]. Similar to our findings, association of lipid profile parameters in T2DM patients were found in earlier study [21].…”

Section: Discussionsupporting

confidence: 92%

Status of vitamin-D in relation to glycemic indices and lipid profile in postmenopausal women with type 2 diabetes mellitus: a case controlled study in Riyadh, KSA

Abudawood¹,

Aljaser²,

Tabassum³

et al. 2018

Biomed Res

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Abnormal vitamin D level and glucose homeostasis are two most chronic medical conditions leading to cardiovascular disease following menopause transition in females. Low levels of vitamin D could be associated with elevated risk of type 2 diabetes mellitus (T2DM). The aim of the present study was to evaluate and compare vitamin D status in relation to glycemic indices, metabolic parameters between pre and postmenopausal women with T2DM. Levels of fasting blood glucose, HbA1C, lipid profile and vitamin D were measured in pre and postmenopausal T2DM women and analysed by SPSS software. Levels of HbA1C, FBG, TC, Tg, LDL-C and obesity parameters like BMI and visceral fat increased significantly (p<0.001) whereas serum levels of HDL-C and vitamin D decreased significantly in postmenopausal T2DM women compared to premenopausal group. Vitamin D was negatively correlated with age, HbA1C, LDL-C at p<0.05. Decreased levels of vitamin D exhibited strong negative correlation with metabolic or obesity factors like BMI and waist circumference. The present investigation unravels the relationship between vitamin D and cholesterol and it was found that HDL-C although decreased with menopause, there was no significant association between HDL-C and decreased vitamin D in postmenopausal T2DM females. Results from this study suggests that hypovitaminosis D accompanied with dyslipidimia, increased BMI and obesity increases the risk factors for cardiovascular diseases in postmenopausal women with T2DM.

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Section: Discussionsupporting

confidence: 92%

Status of vitamin-D in relation to glycemic indices and lipid profile in postmenopausal women with type 2 diabetes mellitus: a case controlled study in Riyadh, KSA

Abudawood¹,

Aljaser²,

Tabassum³

et al. 2018

Biomed Res

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“…Age and course of disease were significantly correlated with DPN, which was consistent with the results of previous studies (12). Vitamin D protects the function of peripheral nerves by inhibiting the inflammatory state of DM patients and reducing the apoptosis of neurons (13). In this study, it was found that SDBG, LAGE, and MBG were increased in the NCVA group, and SDBG was an independent risk factor for abnormal NCV; therefore, we concluded that blood glucose fluctuation was related to DPN.…”

Section: Correlation Of Txnip With Oxidative Stress and Inflammatory mentioning

confidence: 55%

Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus

et al. 2020

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Aims: To investigate the correlation between thioredoxin-interacting protein (TXNIP) and peripheral nerve conduction velocity (NCV) in patients with type 2 diabetes mellitus. Methods: In total, 338 patients with type 2 diabetes mellitus (T2DM) were included in this study. We collected the clinical data and measured the motor conduction velocities of the bilateral ulnar nerve, median nerve, tibial nerve, and common peroneal nerve, and the sensory conduction velocities of the ulnar nerve, median nerve, sural nerve, and superficial peroneal nerve. According to the results, the patients were divided into two groups: normal peripheral nerve conduction group (NCVN group) and abnormal peripheral nerve conduction group (NCVA group). The two groups were then compared in terms of the conventional biochemical index and the sugar metabolic index as well as the serum levels of TXNIP, reduced glutathione (GSH), total superoxide dismutase (SOD), malondialdehyde (MDA), and tumor necrosis factor alpha (TNF-α). The correlation between TXNIP and NCV was also analyzed. Results: Compared with the NCVN group, the TXNIP and MDA values were significantly increased in the NCVA group (P < 0.05). Among the patients with T2DM, age, fasting glucose, SDBG, and TXNIP were risk factors for NCV abnormality, while vitamin D3 was a protective factor. After adjusting for related confounding factors, TXNIP was significantly correlated with NCV (P < 0.05). Among the patients with T2DM, TXNIP was an independent risk factor for left ulnar motor conduction velocity (MCV), right ulnar MCV, left median MCV, and right median MCV. TNF-α was identified as a positive influencing factor for serum TXNIP, while serum TXNIP was a positive factor for TNF-α and MDA (both P < 0.05). Conclusion: Serum TXNIP is related to NCV in T2DM patients. In combination with oxidative stress and inflammation, TXNIP may affect diabetic peripheral neuropathy (DPN).

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“…A vitamin D3 derivative, induced NGF and prevented neurotrophic deficits in streptozotocin-diabetic rats . A recent study has shown positive correlation between vitamin D and serum NGF in people with Type 1 diabetes and neuropathy [27]. Box chart E shows mean IENFD and box chart F shows mean SENFD based on immunoreactivity for PGP9·5 antibody, with 95% confidence interval.…”

Section: Discussionmentioning

confidence: 99%

“…A vitamin D3 derivative, induced NGF and prevented neurotrophic deficits in streptozotocin-diabetic rats [26]. A recent study has shown positive correlation between vitamin D and serum NGF in people with Type 1 diabetes and neuropathy [27]. A study in rodents reported deactivation of vitamin D by the CYP24A1 enzyme in the presence of glucotoxicity [28].…”

Section: Discussionmentioning

confidence: 99%

Reduced vitamin D levels in painful diabetic peripheral neuropathy

Shillo

Selvarajah²,

Greig

et al. 2018

Diabet. Med.

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We have demonstrated a significant difference in 25-hydroxyvitamin D levels in well-characterized people with painful diabetic peripheral neuropathy, while accounting for the main confounding factors. This suggests a possible role for vitamin D in the pathogenesis of painful diabetic peripheral neuropathy. Further prospective and intervention trials are required to prove causality between low vitamin D levels and painful diabetic peripheral neuropathy.

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Does vitamin D have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients?

Abstract: It seems that the most important risk factor for the development of neuropathy in type 1 diabetic patients is disease duration.

Cited by 24 publications

References 32 publications

Status of vitamin-D in relation to glycemic indices and lipid profile in postmenopausal women with type 2 diabetes mellitus: a case controlled study in Riyadh, KSA

Status of vitamin-D in relation to glycemic indices and lipid profile in postmenopausal women with type 2 diabetes mellitus: a case controlled study in Riyadh, KSA

Correlation Between Thioredoxin-Interacting Protein and Nerve Conduction Velocity in Patients With Type 2 Diabetes Mellitus

Reduced vitamin D levels in painful diabetic peripheral neuropathy

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