Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention?

Seijo, Mariana; Bonanno, Marina Soledad; Bryk, Gabriel; Coronel, Magali E. Zeni; Portela, María Luz Pita Martín de; Zeni, Susana Noemí

doi:10.1007/s00223-022-00984-y

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Among them, genetic and environmental factors, as unchangeable factors, can explain 44% to 88% of BMD [ 19 , 20 ]. But as controllable and variable factors, behavioral factors such as nutrition have the greatest impact on the residual variability of bone mass [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Wei,

Zhang,

Yuan

et al. 2024

Nutrients

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(1) Background: Nutrients play an essential role in bone health, whether in achieving peak bone mineral density (BMD) or maintaining bone health. This study explores the relationship between nutrient supply and femoral bone health at different ages. (2) Methods: A total of 5603 participants meeting the inclusion and exclusion criteria were included in this study using the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2010, 2013 to 2014, and 2017 to 2018. Femoral bone mineral density and bone status were dependent variables, and dietary nutrient intake and nutrient intake status were independent variables. The relationship between dietary nutrient intake and bone mineral density was explored, and the importance of nutrients affecting bone status was analyzed through a neural network model. At the same time, we investigated the relationship between nutrient intake and bone status. (3) Results: The peak of age and femoral bone mineral density appeared at 20 years old in our study. After grouping by age, logistic regression analysis showed that before 20 years old, without adjusting other variables, high-fat diet was more likely to have normal bone mass than appropriate fat diet (OR: 4.173, 95%CI: 1.007–17.289). After adjusting for all demographic factors, niacin intake (OR: 1.062, 95%CI: 1.019–1.108) was beneficial for normal bone mass, while vitamin B6 intake (OR: 0.627, 95%CI: 0.408–0.965) was not. After 20 years old, after adjusting for carbohydrate, protein, vitamin B6, niacin, dietary fat, vitamin B2, and vitamin B12, vitamin B2 intake (OR: 1.153, 95%CI: 1.04–1.278) was beneficial for normal bone mass, while vitamin B6 intake (OR: 0.842, 95%CI: 0.726–0.976) was not. After adjusting for all confounding factors, vitamin B2 intake (OR: 1.288, 95%CI: 1.102–1.506) was beneficial for normal bone mass. In addition, we found that even if there was no statistical significance, the effects of high-fat diet on bone mass were different at different ages. (4) Conclusions: By conducting an in-depth analysis of the NHANES database, this study reveals that dietary factors exert divergent effects on bone health across different age groups, implying the necessity of implementing tailored dietary strategies to maintain optimal bone health at distinct life stages.

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Section: Discussionmentioning

confidence: 99%

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Wei,

Zhang,

Yuan

et al. 2024

Nutrients

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“…Non-digestible oligosaccharides (NDOs), such as galactooligtosaccharides (GOS), fructooligosaccharidesc (FOS), oligofructose, and inulin are regarded as the most beneficial prebiotics to bone health. Application of FOS, GOS and inulin not only promotes growth (Scholz-Ahrens et al, 2007;Edwards et al, 2020), but also effectively prevent the bone loss induced by ovarian hormone deficiency (Mathey et al, 2004;Zafar et al, 2004;Hooshmand et al, 2010;Seijo et al, 2019). Prebiotics also exert favorable impacts on bone health by regulating microbial ecology, promoting SCFAs production, and facilitating nutrition absorption (Scholz-Ahrens et al, 2007;Edwards et al, 2020).…”

Section: Prebioticsmentioning

confidence: 99%

The associations of gut microbiota, endocrine system and bone metabolism

Kuang

Zhang

et al. 2023

Front. Microbiol.

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Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the “gut-bone axis.” Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and bone metabolism. This review article discussed the complex interactions between gut microbiota and bone metabolism-related hormones, including sex steroids, insulin-like growth factors, 5-hydroxytryptamine, parathyroid hormone, glucagon-like peptides, peptide YY, etc. Although the underlying mechanisms still need further investigation, the regulatory effect of gut microbiota on bone health via interplaying with endocrine system may provide a new paradigm for the better management of musculoskeletal disorders.

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“…In 2011, National Academies Press of the US stated that humans absorb almost 30% of the calcium from food depending on the amount and type of the food, plus several other factors. Food-related calcium absorption improves by vitamin D intake (54) and decreases by age and life stage from 60% in infants and younger age to 20-25% in adulthood (40). Also, other components in food can interact with calcium absorption.…”

Section: Dietary Calcium Sourcesmentioning

confidence: 99%

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

Mirani,

Horváth,

Vecsernyés

et al. 2023

Preprint

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Background Calcium intake is an essential component of a healthy diet and has been linked to numerous health benefits, including the prevention of osteoporosis and reduction of fracture risk in children and adults. The most plausible consequence of insufficient calcium intake can lead to osteoporosis over decades, which is a significant cause of morbidity and mortality with high burden of disease. However, attention should be given to the risk of potential overdoses, since some trials have linked excessive calcium supplementation to increased risk of health complications.Methods Our study aimed to evaluate the possible factors influencing the participants’ calcium profile through a “dietary intake specific questionnaire” to achieve the optimal calcium and vitamin D intake in the prevention of or during therapies for osteoporosis. A comprehensive multi-dimensional dietary survey was administered to evaluate various aspects of the participants' diets, including dietary and supplemented calcium intake, vitamin D exposure, vitamin supplementation profile, and relevant lifestyle parameters. In this article, we specifically analyzed the calcium intake profiles and pharmacovigilance aspects of the study participants.Results We received 478 evaluable datasets. The dietary calcium intake, on average, was close to optimal in the general public. Supplementation safety concerns were raised for the public in less than 7% of patients, who were reported to have a potential overload in daily calcium intake. Albeit, one-third (34%) of the population had a significant deficiency (average: 544 mg/day), and this effect was more relevant among ≤ 25-years old individuals, of them only less than 37% of the responders had an optimal calcium intake. More than half (52%) of the dietary calcium deficient participants did not take any additional calcium supplements. Although, in 73% of general population, most calcium supplementation dosage in use was equal to or below 200 mg/day.Conclusion Our study highlights the importance to implement a “Patient Focused Motivation Strategy” as a broader approach in pharmaceutical care for increasing the patient’s knowledge, understanding the needs of supplementation, and selecting the correct form and dose of the available non-prescription products. It is important to maintain motivation and adherence to the recommended therapy to achieve optimal health outcomes.

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Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention?

Cited by 4 publications

References 48 publications

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

Opposing Effects of Nutritional Supply on Bone Health at Different Ages: Based on the National Health and Nutrition Examination Survey Database

The associations of gut microbiota, endocrine system and bone metabolism

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

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