Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials

Dinca, Madalina; Şerban, Corina; Sahebkar, Amirhossein; Mikhailidis, Dimitri P.; Tóth, Peter P.; Martin, Seth S.; Blaha, Michael J.; Blüher, Matthias; Gurban, Camelia; Penson, Peter E.; Michos, Erin D.; Hernandez, Adrián V.; Jones, Steven R.; Banach, Maciej

doi:10.1016/j.phrs.2016.03.035

Cited by 66 publications

(47 citation statements)

References 46 publications

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“…While it should be noted that the placebo group tended to have slightly milder baseline measures of severe obesity and metabolic dysfunction compared to the vitamin D group, these differences were not statistically significant and, thus, we hypothesize that this divergence played a negligible effect on the main findings of this study. In support of our findings obtained by WIB on cholecalciferol and placebo, previous studies showed that supplementation with vitamin D 3 at therapeutic doses did not impact total adiponectin concentrations [27], but it selectively increased HMW-A levels in obese adolescents treated for 1 year with cholecalciferol [28]. While our study and other studies failed to record associations between short-term increases of HMW-A and improvements in insulin sensitivity [20,21], long-term studies documented a significant correlation between modifications of HMW-A and insulin sensitivity [29,30,48].…”

Section: Discussionsupporting

confidence: 89%

“…Partly contradictory results exist on the adipogenic effect of 1,25(OH) 2 Vit D [37], which was shown to inhibit adipogenesis in 3T3-L1 mouse preadipocyte cell lines [49], while promoting adipogenesis and increasing adiponectin expression in primary mouse and human subcutaneous preadipocytes [50]. Similarly, treatment with 1,25(OH) 2 Vit D in 3T3-L1 cells was found to stimulate the synthesis of adiponectin and its multimeric forms [27]. Moreover, a key regulator of folding and assembly of adiponectin, the endoplasmatic reticulum (ER) chaperon DsbA-L, was found to be upregulated by 1,25(OH) 2 Vit D, which suggests that vitamin D regulation of adiponectin may involve post-transcriptional mechanism/s [28].…”

Section: Discussionmentioning

confidence: 99%

“…Cross-sectional studies found a positive association between circulating adiponectin and 25(OH)Vit D levels [22,23,24], as well as between VDD and hypoadiponectinemia [25,26]. While meta-analytic data failed to prove stimulatory effects of cholecalciferol supplementation on total adiponectin concentrations [27], it has been shown in obese children that VDD is associated with lower expression of adiponectin isoforms, particularly HMW-A, while 1 year supplementation with cholecalciferol was shown to upregulate HMW-A expression independent of changes in BMI [28]. Pediatric studies also found that the increase in HMW-A levels was correlated with improvements in insulin sensitivity [29,30].…”

Section: Introductionmentioning

confidence: 99%

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Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin

et al. 2017

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Obesity predisposes to vitamin D deficiency (VDD) and glucose abnormalities. It is currently debated if vitamin D administration may improve glucose homeostasis by interacting with modulators of insulin sensitivity, such as adiponectin and its oligomers. In a 4-week inpatient study on a metabolic rehabilitation program, consisting of individualized caloric restriction and aerobic physical exercise in obese subjects with VDD, we assessed the acute effects of 600,000 IU cholecalciferol given per os VD group, 12 subjects; body mass index (BMI) 42.7 ± 1.3 kg/m2) or placebo per os (PL group, 12 subjects, BMI 39.8 ± 0.9 kg/m2) on high (HWM-A), medium (MMW-A), and low molecular weight adiponectin (LMW-A), as quantified by western immunoblot (WIB) and ELISA. During the 4-week study, dieting promoted a similar magnitude of weight loss in VD and PL groups. Compared to the PL group, cholecalciferol administration increased 25(OH)Vit D levels (p < 0.001) and promoted a significant increase of HMW-A expression analyzed by WIB (p = 0.02). In parallel, a significant decrease of leptin/HMW-A ratio (p < 0.05), a biomarker of metabolic homeostasis, was observed. During the study, changes of MMW-A and LMW-A occurred independently of cholecalciferol administration, and were likely explained by weight loss. At odds with these findings, the ELISA assessment of adiponectin oligomers showed no modifications in the VD group or PL group. Current findings suggest that acute cholecalciferol administration selectively modifies HMW-A and the leptin/HMW-A ratio.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin

et al. 2017

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“…A meta-analysis of observational studies and randomised controlled trials has demonstrated an inverse association between leptin levels and 25(OH)D concentration in observational studies, which was not corroborated in intervention studies with high heterogeneity [56]. Another meta-analysis that aimed to elucidate the role of vitamin D supplementation on serum adipokines failed to demonstrate a significant effect of vitamin D treatment on adiponectin and leptin levels [57]. …”

Section: Osas and Vitamin D Insufficiencymentioning

confidence: 99%

The role of vitamin D in obstructive sleep apnoea syndrome

Archontogeorgis

Nena

Παπάνας

et al. 2018

Breathe

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Obstructive sleep apnoea syndrome (OSAS) is a common disorder of multifactorial pathogenesis and is associated with obesity, diabetes and cardiovascular disease. Vitamin D is a fat-soluble vitamin with an important function in calcium absorption and homeostasis, which is also implicated in several nonskeletal conditions. The prevalence of vitamin D deficiency is increasing worldwide and is associated with similar metabolic disturbances to OSAS. Moreover, recent data suggest that in OSAS patients serum levels of vitamin D are lower compared with non-apnoeic subjects. However, the mechanisms linking vitamin D deficiency and OSAS are not completely understood and several hypotheses have been advanced. To date, a limited number of studies have assessed the association between lower serum concentrations of vitamin D and OSAS, and have reported inconsistent results. Similarly, contradictory results have been produced by studies which evaluated the effect of continuous positive airway pressure treatment on serum vitamin D levels. The aim of this review is to summarise current knowledge on the association between OSAS and vitamin D levels.Key pointsVitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions.Educational aimsTo assess the potential association between OSAS and serum levels of vitamin D.To discuss the pathogenetic mechanisms linking OSAS and vitamin D insufficiency.To illustrate the effect of CPAP treatment on vitamin D concentration in OSAS patients.

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“…Higher adiponectin levels are attributed to a lower risk of developing type 2 diabetes mellitus (T2DM) with a dose-response relationship [3, 4]. Glucose-lowering and insulin sensitizing effects have been observed after administration of adiponectin in mice [2, 5, 6].…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blind clinical trial

Mazaherioun

Saedisomeolia

Javanbakht

et al. 2017

aoms

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IntroductionThere is evidence that n-3 polyunsaturated fatty acids (n-3 PUFAs) exert beneficial effects to improve type 2 diabetes mellitus (T2DM), but its complications remain poorly understood. Hypoadiponectinemia is one of the important mechanisms responsible for T2DM which necessitates developing novel therapeutic strategies. We aimed to determine the effect of n-3 PUFA supplementation on circulating adiponectin and mRNA expression of adiponectin receptors (AdipoR1, AdipoR2) and Sirt-1 in T2DM patients.Material and methodsA randomized, double-blind, placebo-controlled trial of 10-week follow-up of n-3 PUFAs (2.7 g/day) vs. placebo in T2DM patients (n = 88) was conducted. In detail, T2DM patients (n = 44) were treated with n-3 PUFAs and the remainder received placebo. Anthropometric and metabolic characteristics were assessed in all participants. Circulating level of adiponectin and mRNA expression of AdipoR1, AdipoR2 and Sirt-1 were measured in peripheral blood mononuclear cells (PBMC) using real-time polymerase chain reaction before and after the intervention.ResultsIt was found that n-3 PUFAs increased AdipoR1 gene expression (fold change = 1.321 in n-3 PUFAs vs. 1.037 in placebo) and AdipoR2 mRNA (fold change = 1.338 in n-3 PUFAs vs. 1.034 in placebo). No significant changes were observed for Sirt-1 expression. The serum level of adiponectin significantly (p = 0.035) increased in n-3 PUFAs (5.09 to 5.58 μg/ml) but remained unchanged in the placebo group.ConclusionsDaily supplementation with n-3 PUFAs (2.7 g) was effective to significantly improve gene expression of AdipoR1 and AdipoR2 and the serum level of adiponectin in T2DM patients. Therefore, n-3 PUFAs might emerge as an adjuvant for current antidiabetic therapies. However, confirmatory long-term studies are required.

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Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials

Cited by 66 publications

References 46 publications

Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin

Acute Vitamin D3 Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin

The role of vitamin D in obstructive sleep apnoea syndrome

Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blind clinical trial

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