Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Özkan, Özlem Persil; Yiğit, Ece; Yiğit, Zerrin

doi:10.15537/smj.2019.4.24007

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Our primary finding that overall tHcy levels are not affected by diet-induced weight loss in people with obesity-related DM, has previously also been shown by studies among obese people, without diabetes [ 19 , 22 ]. With this, tHcy does not appear to be a mediating factor in the beneficial effect of weight loss on cardiovascular complications in patients with T2D.…”

Section: Discussionsupporting

confidence: 71%

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The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes

Al Fatly,

Mulder,

Roeters van Lennep

et al. 2024

Nutr J

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Background/aims Having type 2 diabetes (T2D) in combination with being overweight results in an additional increase in cardiovascular disease (CVD) risk. In addition, T2D and obesity are associated with increased levels of total homocysteine (tHcy), possibly contributing to the CVD risk. Weight loss dieting has positive effects on several CVD risk factors, but whether it affects tHcy remains unclear. Therefore, the aim of this study was to determine the effect of a calorie restricted diet on tHcy in overweight people with T2D. Methods In this post-hoc analysis of the POWER study, adults with T2D and a BMI greater than 27 kg/m² were included from the outpatient diabetes clinic of the Erasmus Medical Center, Rotterdam. The patients were subjected to a very low-calorie diet with fortified meal replacements for 20 weeks. Before and after this intervention, blood samples were collected to measure tHcy and other CVD risk factors like glycaemic and lipid parameters. Results 161 overweight participants with T2D were included, with a mean age of 54 years (range 26–74), mean weight of 104.6 ± 19.9 kg and mean HbA1c of 62.7 ± 14.3 mmol/mol. At baseline, men displayed higher tHcy than women, and tHcy level was positively correlated with body weight and triglyceride levels, while it was negatively correlated with renal function and HDL cholesterol. During the intervention, bodyweight was reduced by a mean of 9.7% (from 104.6 ± 19.9 to 94.5 ± 18.1 kg p < 0.001), and all measured glycaemic and lipid blood parameters improved significantly. However, tHcy remained unchanged (from 12.1 ± 4.1 to 12.1 ± 4.2 umol/L, p = 0.880). The change in tHcy during the intervention was negatively associated with the change in weight and BMI (p = 0.01 and p = 0.008, respectively). People who lost < 10 kg (n = 92) had a mean tHcy change of -0.47 umol/L, while people who lost more than ≥ 10 kg (n = 69) had a mean tHcy change of 0.60 umol/L (p = 0.021). Conclusion In conclusion, our data show that a calorie restricted diet does not affect tHcy in people with T2D and obesity, despite the use of meal replacements fortified with folic acid and vitamin B12. Our data showed a negative correlation between change in tHcy levels and weight loss, suggesting that people who lost more weight (> 10 kg) showed an increase in tHcy. Future studies should explore the potential increase in tHcy induced by weight loss dieting and target the question if tHcy reduction strategies during weight loss could be clinically beneficial.

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Section: Discussionsupporting

confidence: 71%

“…However, whether tHcy is a mediating factor between weight loss and reduction of CVD risk is not known. Weight loss through a calorie-restricted diet in obese people without diabetes did not lead to a change in Hcy levels [ 19 ]. Whether weight loss affects tHcy levels in people with obesity related T2D is currently unknown.…”

Section: Background/aimmentioning

confidence: 99%

The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes

Al Fatly,

Mulder,

Roeters van Lennep

et al. 2024

Nutr J

View full text Add to dashboard Cite

show abstract

“…There have been very limited and conflicting data assessing outcome differences with pursuit of weight loss by various methods in patients with type 2 diabetes versus those without (8,9). Certain medications used for glycemic control, such as insulin and sulfonylureas, are known to cause weight gain.…”

Section: Introductionmentioning

confidence: 99%

The effect of nonpharmaceutical weight‐loss interventions in rural patients with diabetes: RE‐POWER Diabetes

Desouza

Johnson‐Rabbett

Gajewski

et al. 2022

Obesity

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Objective In this secondary analysis of the Rural Engagement in Primary Care for Optimizing Weight Reduction (RE‐POWER) randomized trial, the authors determined the effectiveness of weight‐loss interventions in people with diabetes compared with those without diabetes living in rural areas. Methods The RE‐POWER study was a randomized trial designed to determine the effectiveness of nonpharmacological behavioral weight‐loss interventions in rural participants with obesity, comparing the individual in‐clinic visit model to in‐person group sessions and phone group sessions over 24 months. In this secondary analysis, weight loss was compared in participants with and without diabetes. The effects of factors such as medications, insulin, and behavioral factors were compared. Results Participants with diabetes were less likely to lose weight during the study compared with those without diabetes up to 18 months (4.12% vs. 5.31%; net difference = 1.46%; 95% CI: 0.63%‐2.28%). Participants with diabetes on insulin lost less weight than patients with diabetes not on insulin at 6 months (4.52% vs. 6.88%; net difference = 2.35%; 95% CI: 0.55%‐4.16%). The group with diabetes had significantly lower changes in blood pressure and lipid parameters versus the group without diabetes. Conclusions Patients with diabetes in rural areas were less likely to lose weight, and metabolic parameters were less responsive to weight loss, compared with patients without diabetes.

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Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Cited by 2 publications

References 27 publications

The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes

The effect of diet-induced weight loss on circulating homocysteine levels in people with obesity and type 2 diabetes

The effect of nonpharmaceutical weight‐loss interventions in rural patients with diabetes: RE‐POWER Diabetes

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