Does White Wine Qualify for French Paradox? Comparison of the Cardioprotective Effects of Red and White Wines and Their Constituents: Resveratrol, Tyrosol, and Hydroxytyrosol

Dudley, Jocelyn; Lekli, István; Mukherjee, Subhendu; M, Das; Bertelli, A.; Das, Dipak K.

doi:10.1021/jf801791d

Cited by 85 publications

(71 citation statements)

References 48 publications

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“…We would like to put forward that other polyphenolic compounds present in white wine may exert beneficial effects on lung function as well. Plausible candidates in this respect are tyrosol and hydroxytyrosol, polyphenolic white wine molecules that, similar to resveratrol, exhibit antioxidant and cardioprotective effects in vivo [32]. Other candidates are flavonoids that were associated with a higher FEV1 in the MORGEN study [33].…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and lung function in the general population: wine and resveratrol intake

Siedliński¹,

Boer²,

Smit³

et al. 2011

Eur Respir J

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Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT)1 activity. We assessed the impact of wine and resveratrol intake, and SIRT1 single-nucleotide polymorphisms (SNPs) on lung function in the general population.Effects of red and white wine and resveratrol intake on forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC were analysed in the population-based Doetinchem cohort (n53,224). Associations of four tagging SIRT1 SNPs with lung function were analysed in the Doetinchem (n51,152) and Vlagtwedde-Vlaardingen (n51,390) cohorts.Resveratrol intake was associated with higher FVC levels, and white wine intake with higher FEV1 levels and lower risk of airway obstruction. SIRT1 SNPs were not significantly associated with level or course of lung function, either directly or indirectly via wine or resveratrol intake.This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV1, and additionally shows an association with a higher FEV1/FVC ratio. These effects probably do not run via SNPs in SIRT1.

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Section: Discussionmentioning

confidence: 99%

Dietary factors and lung function in the general population: wine and resveratrol intake

Siedliński¹,

Boer²,

Smit³

et al. 2011

Eur Respir J

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“…FIGURE 4. Effects of low and high doses of resveratrol on the expression of some survival pathway members like Akt, Bcl2 and Ref-1 (Graphs are re-plotted from Dudley et al, 2008b …”

Section: +mentioning

confidence: 99%

Dose-Dependency of Resveratrol in Providing Health Benefits

2010

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“…Our ongoing studies (unpublished) in human liver cells seem to indicate that quercetin up regulates PON1 gene via the activation and nuclear translocation of mature SREBP2, which then interacts with SRE elements of PON1 promoter to stimulate its activity. Resveratrol, another polyphenolic compound in red wine, has been reported to have angiogenic and antihypercholesterolemic and antidiabetic effects [118]. The cardioprotective effects of resveratrol was ascribed to increased expression of phospho-Akt, Bcl-2, Relative PON1 Expression Fig.…”

Section: Possible Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

Is alcohol beneficial or harmful for cardioprotection?

et al. 2009

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While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher prevalence of CAD. In several other studies of cardiovascular mortalities, abstainers and heavy drinkers are at higher risk than light or moderate drinkers. The composite of this disparate relation in several population studies of cardiovascular mortality has been a ''U-'' or ''J-''shaped curve. Apart from its ability to eliminate cholesterol from the intima of the arteries by reverse cholesterol transport, another major mechanism by which HDL may have this cardioprotective property is by virtue of the ability of its component enzyme paraoxonase1 (PON1) to inhibit LDL oxidation and/or inactivate OxLDL. Therefore, PON1 plays a central role in the disposal of OxLDL and thus is antiatherogenic. Furthermore, PON1 is a multifunctional antioxidant enzyme that can also detoxify the homocysteine metabolite, homocysteine thiolactone (HTL), which can pathologically cause protein damage by homocysteinylation of the lysine residues, thereby leading to atherosclerosis. We demonstrated that moderate alcohol up regulates liver PON1 gene expression and serum activity, whereas heavy alcohol consumption had the opposite effects in both animal models and in humans. The increase in PON1 activity in light drinkers was not due to preferential distribution of high PON1 genotype in this group. It is well known that wine consumption in several countries shows a remarkable inverse correlation to local rates of CAD mortality. Significantly, apart from its alcohol content, red wine also has polyphenols such as quercetin and resveratrol that are also known to have cardioprotective effects. We have shown that quercetin also up regulates PON1 gene in rats and in human liver cells. The action of quercetin seems to be mediated via the active form of the nuclear lipogenic transcription factor, sterol-regulatory element-binding protein 2 (SREBP2) that is translocated from endoplasmic reticulum to the nucleus. However, the mechanism of action of ethanol-mediated up-regulation of PON1 gene remains to be elucidated. We conclude that both moderate ethanol and quercetin, the two major components of red wine, exhibit cardioprotective properties via the up-regulation of the antiatherogenic gene PON1.

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Does White Wine Qualify for French Paradox? Comparison of the Cardioprotective Effects of Red and White Wines and Their Constituents: Resveratrol, Tyrosol, and Hydroxytyrosol

Cited by 85 publications

References 48 publications

Dietary factors and lung function in the general population: wine and resveratrol intake

Dietary factors and lung function in the general population: wine and resveratrol intake

Dose-Dependency of Resveratrol in Providing Health Benefits

Is alcohol beneficial or harmful for cardioprotection?

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