DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status

Abstract

Summary Primary acinic cell carcinoma (ACC) of the lung is an extremely rare neoplasm that more often arises near to a right bronchus. It is characterized by two populations of clear and dark eosinophilic cells, arranged in a glandular acinar pattern. Mitosis are rare and tumor cells show small and eccentric nuclei. Positive stain for PAS, PAS-D, cytokeratin, A1AT and A1ACT is reported, while TTF1, p40, synaptophysin, SMA, and S100 are substantially negative. DOG-1 positive stain was observed in ACC of the salivary glands and its negativity was proposed to distinguish between primary and metastatic ACC of the lung. Here, we report the 30th case of primary ACC of the lung, describing the immunohistochemical positivity for DOG-1 and the molecular status of the neoplasm for the first time.

Primary acinic cell carcinoma of the trachea: A case report and literature review

“…[5] To the best of our knowledge, including the present case, only 32 patients with primary ACC of the lung or trachea have been reported so far. [5–26] Clinicopathological features of the patients are summarized in Table 1. The most common symptoms were hemoptysis and coughing, but 1-third (11/32) of the patients were asymptomatic and the tumor was identified incidentally.…”

“…The most common symptoms were hemoptysis and coughing, but 1-third (11/32) of the patients were asymptomatic and the tumor was identified incidentally. [5–26] Of the patients with primary ACC of the lungs, 14 were female and 17 were male. The patient age varied widely between 4 to 75 years (mean age: 43.4 years).…”

“…Symptoms Yr Sex Age Size (cm) Site Therapy Outcome 1 [5] Asymptomatic 1972 M 63 4.2 RLL S A, 22 mo 2 [6] Recurrent pulmonary infections 1976 F 12 0.8 RML, bronchus intermedius S A, 1 yr 3 [7] Three-year history of hemoptysis 1982 M 54 2.2 Trachea S A, 2 yr 4 [8] Persistent cough 1985 M 36 4 RML Unknown Unknown 5 [9] Incidental 1992 F 44 3.5 RML, subpleural S A, 10 yr 6 [9] Incidental 1992 F 48 4 LUL, parenchymal S LF 7 [9] Incidental 1992 F 50 1.7 RML, subpleural S A, 3 yr 8 [9] Persistent cough 1992 M 63 1.2 RML, endobronchial S A, 4 yr 9 [9] Incidental 1992 F 75 1.5 RUL, subpleural S A, 4 yr 10 [10] Dyspnea, cough, stridor 1994 M 31 2 Trachea S A, 8 yr 11 [11] Hemoptysis 1996 M 59 3 Trachea S ND 12 [12] Incidental 1999 M 64 3 LLL, endobronchial S, radiation A, 1.5 yr 13 [13] Incidental 2003 F 30 2 RLL, subpleural S R, 20 mo 14 [14] Incidental 2003 M 70 4 RLL, intraparenchymal S ND 15 [15] Hemoptysis and night sweats 2004 F 4 3 LUL, endobronchial S ND 16 [16] Hoarseness 2004 M 54 5 Trachea S A, 23 mo 17 [17] Persistent cough 2004 M 58 1.5 RML, endobronchial S A, 4 mo 18 [18] Incidental 2005 F 37 3.3 RUL S ND 19 [19] Incidental 2006 M 47 1.8 LLL, endobronchial S A, 1 yr 20 [20] Asymptomatic 2010 M 68 1.8 LLL S, chemotherapy ND 21 [21] Incidental 2011 M 63 5.2 RUL S A 22 [22] Persistent cough 2011 F 55 1.3 RUL S, chemotherapy A, 3 yr 23 [23] Persistent cough 2017 M 31 4.5 RLL, subpleural S ND 24 [24] Persistent cough, hemoptysis 2019 F 10 1.5 LUL S A, 30 mo 25 [24] Persistent cough, chest pain 2019 M 25 2.2 RUL S A, 48 mo 26 [24] Hemoptysis 2019 M 37 1 RLL S A, 8 mo 27 [24] Persistent cough, hemoptysis 2019 F 8 0.4 LML S A, 33 mo 28 [24] Persistent cough, hemoptysis 2019 M 28 1 RML S A, 31 mo 29 [24] Hemoptysis 2019 F 53 1.5 RML S A, 28 mo 30 [25] Persistent cough, hemoptysis 2021 F 27 8.6 RUL, endobronchial S A, 24 mo 31 [26] Persistent…”

Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

“…At least 32 cases of AciCC primary to the lung have been reported. [16][17][18][19] These tumours are usually associated with a bronchus or the trachea, although two cases were found deep in the pulmonary parenchyma. 159,160 Four cases were reported in paediatric patients, aged 4-12 years, 18,46,47 three of which were associated with a foreign body.…”

“…The most common types of pulmonary salivary gland-type carcinoma include mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (AdCC), and epithelial-myoepithelial carcinoma (EMC). 6,8,[10][11][12][13] Case reports and series have also described hyalinizing clear cell carcinoma (HCCC), 4,14,15 acinic cell carcinoma (AciCC), [16][17][18][19] secretory carcinoma, [20][21][22][23] salivary duct carcinoma, [24][25][26] intraductal carcinoma, 27,28 and polymorphous adenocarcinoma [29][30][31][32][33] occurring as primary lung tumours. Benign salivary gland-type tumours reported in the lung include myoepithelial tumours and pleomorphic adenomas.…”