Dog Model Holds Promise for Early Mechanical Unloading in Patients With Acute Myocardial Infarction

Guerrero‐Miranda, Cesar; Hall, Shelley

doi:10.1161/circheartfailure.118.004972

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the past decade, the use of temporary mechanical circulatory support (TMCS) has increased rapidly in the treatment of patients with RCS and is associated with reduced hospital costs and, in some cases, reduced inhospital mortality (9). TMCS devices intend to restore systemic perfusion and prevent further end-organ damage until the insult that resulted in cardiogenic shock is addressed (10). In cases of RCS with biventricular failure and reduced systemic oxygenation, VA-ECMO can provide full cardiopulmonary support and is thus used as a rescue TMCS.…”

Section: Use Of Va-ecmo In Rcsmentioning

confidence: 99%

Cardiac catheterization and percutaneous intervention procedures on extracorporeal membrane oxygenation support

Guerrero‐Miranda¹,

Hall²

2019

Ann. Cardiothorac. Surg.

Self Cite

View full text Add to dashboard Cite

Extracorporeal membrane oxygenation (ECMO) is used to support critically ill patients when conventional therapies have failed. ECMO has been available for four decades and has gained use as a rescue therapy in severe refractory hypoxic disorders and in patients with refractory cardiogenic shock (RCS). Over recent years, several percutaneous cardiac interventions and implant devices have been developed that are now used frequently in conjunction with ECMO in order to maintain organ perfusion. Here, we review the literature on VA-ECMO cannulation location, the use of VA-ECMO in interventions (e.g., coronary interventions and structural heart interventions) and percutaneous cardiac device implantation in VA-ECMO recipients with RCS.

show abstract

Section: Use Of Va-ecmo In Rcsmentioning

confidence: 99%

Cardiac catheterization and percutaneous intervention procedures on extracorporeal membrane oxygenation support

Guerrero‐Miranda¹,

Hall²

2019

Ann. Cardiothorac. Surg.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various acute coronary occlusion models have been used in experimental studies of myocardial infarction pathophysiology and drug intervention, laying an important technical foundation for the exploration of coronary heart disease treatments [3,4]. Dogs and miniature pigs are widely used to study acute myocardial infarction because of the similarity of their circulatory systems, tissue structure, and coronary artery distributions to human hearts.…”

Section: Introductionmentioning

confidence: 99%

A canine acute coronary occlusion model using thrombus implantation by percutaneous coronary intervention

Ma,

Yang,

Zhang

et al. 2023

iRADIOLOGY

View full text Add to dashboard Cite

ObjectiveTo establish an acute canine coronary artery occlusion model by implanting a mixed thrombus prepared in vitro into the coronary artery by percutaneous coronary intervention (PCI).MethodsThis study included 14 healthy Beagle dogs aged 10–13 months. First, 5 ml of canine venous blood was drawn to prepare the coronary artery thrombus in vitro. The thrombus was then implanted into the canine coronary artery by PCI to establish an animal model of acute coronary artery occlusion. Dogs were randomly divided into two experimental groups: group A, in which dogs were assessed for 2 h after coronary occlusion, and group B, in which dogs were assessed for 4 h after surgery. Baseline and postoperative assessment included cardiac troponin T (cTnT) levels, electrocardiography (ECG), plain and contrast echocardiography, and large‐scale digital subtraction angiography (DSA).ResultsCanine venous blood was successfully used to prepare a mixed thrombus with reticular fibrin structure and activated platelets in vitro. After the mixed thrombus was implanted into the coronary artery, large‐scale DSA showed no contrast medium perfusion, confirming complete occlusion of the coronary artery. After the coronary artery occlusion, dogs in both groups showed ST segment elevation >0.5 MV, a 0.9 μg/L increase in CTnT (p < 0.001), and increased EDV and ESV. Dogs also showed decreased left ventricular EF and FS and decreased MBF in the infarcted area (p < 0.05).ConclusionsAn experimental model of acute coronary artery occlusion in dogs was successfully established by implanting a mixed thrombus developed in vitro into the coronary artery using minimally invasive PCI.

show abstract

Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments

et al. 2022

View full text Add to dashboard Cite

In the modern world, myocardial infarction is one of the most common cardiovascular diseases, which are responsible for around 18 million deaths every year or almost 32% of all deaths. Due to the detrimental effects of COVID-19 on the cardiovascular system, this rate is expected to increase in the coming years. Although there has been some progress in myocardial infarction treatment, translating pre-clinical findings to the clinic remains a major challenge. One reason for this is the lack of reliable and human representative healthy and fibrotic cardiac tissue models that can be used to understand the fundamentals of ischemic/reperfusion injury caused by myocardial infarction and to test new drugs and therapeutic strategies. In this review, we first present an overview of the anatomy of the heart and the pathophysiology of myocardial infarction, and then discuss the recent developments on pre-clinical infarct models, focusing mainly on the engineered three-dimensional cardiac ischemic/reperfusion injury and fibrosis models developed using different engineering methods such as organoids, microfluidic devices, and bioprinted constructs. We also present the benefits and limitations of emerging and promising regenerative therapy treatments for myocardial infarction such as cell therapies, extracellular vesicles, and cardiac patches. This review aims to overview recent advances in three-dimensional engineered infarct models and current regenerative therapeutic options, which can be used as a guide for developing new models and treatment strategies.

show abstract

Dog Model Holds Promise for Early Mechanical Unloading in Patients With Acute Myocardial Infarction

Cited by 3 publications

References 16 publications

Cardiac catheterization and percutaneous intervention procedures on extracorporeal membrane oxygenation support

Cardiac catheterization and percutaneous intervention procedures on extracorporeal membrane oxygenation support

A canine acute coronary occlusion model using thrombus implantation by percutaneous coronary intervention

Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments

Contact Info

Product

Resources

About