DOI: 10.14260/jemds/2014/ 4012 ORIGINAL ARTICLE J of Evolution of Med and Dent Sci/ eISSN - 2278 - 4802 , pISSN - 2278 - 4748/ Vol . 3/ Issue 70 / Dec 1 5 , 2014 Page 14963 TO STUDY THE EFFECT OF ADDITION OF NALBUPHINE TO INTRATHECAL BUPIVACAINE USED FOR ELDERLY PATIENT IN LOWER ABDOMINAL SURGERIES UNDER SPINAL ANAESTHESIA : A RANDOMISED DOUBLE BLINDED CONTROL STUDY

Dubey, Rashmi; Bisht, Swati

doi:10.14260/jemds/2014/4012

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Dubey and Bisht [16] conducted a randomized study and concluded that nalbuphine provides better quality of block as compared to Bupivacaine alone. It also prolongs post-operative analgesia when used as adjuvant to spinal bupivacaine in elderly patients [15].…”

Section: Discussionmentioning

confidence: 99%

A Comparison Between Intrathecal Nalbuphine and Dexmedetomidine as Adjuvants to Hyperbaric Bupivacaine for Lower Limb Orthopedic Surgeries

GEETANJALI SINGHAL,

ARUN KUMAR SAXENA,

GAGAN BHARADWAJ

2023

Asian J Pharm Clin Res

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Objective: Sub arachnoid block is a reasonably safe and simple technique of regional anesthesia. This randomized double-blind study was conducted to compare the efficacy of intrathecal nalbuphine and Dexmedetomidine as adjuvant with hyperbaric bupivacaine for lower limb orthopedic surgeries. Methods: Sixty adult patients of American Society of Anaesthesiologists physical status 1 and 2 who were scheduled for elective lower limb orthopedic surgeries were divided into two groups, D and N, of 30 each. Group D patients received dexmedetomidine 4 mcg and Group N received nalbuphine 2 mg as adjuvant along with bupivacaine heavy 0.5% (3 mL) intrathecally. Sensory and motor block characteristics and time to first rescue analgesic (intravenous tramadol 100 mg) were the primary end points and drug-related side effects such as pruritis, nausea, vomiting, and respiratory depression were taken as secondary end points. Subsequently, data were entered into Microsoft Excel spreadsheet and Statistical Package for the Social Science software version 22 was used for statistical analysis. Results: All 60 patients showed adequate block. The onset of sensory and motor block was statistically comparable in both groups. The duration of sensory and motor block and duration of analgesia were markedly extended in dexmedetomidine group patients. There were no significant intraoperative or post-operative side-effects in both group of patients. Conclusion: Dexmedetomidine (4 mcg) increases the sensory and motor block duration and duration of post-operative analgesia significantly more than nalbuphine (2 mg), when administered intrathecally as an adjuvant to bupivacaine (15 mg).

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Section: Discussionmentioning

confidence: 99%

A Comparison Between Intrathecal Nalbuphine and Dexmedetomidine as Adjuvants to Hyperbaric Bupivacaine for Lower Limb Orthopedic Surgeries

GEETANJALI SINGHAL,

ARUN KUMAR SAXENA,

GAGAN BHARADWAJ

2023

Asian J Pharm Clin Res

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“…A randomized trial by Dubey et al (2014) [13] found that nalbuphine offers a superior grade of block than bupivacaine alone. When administered as an adjuvant to spinal bupivacaine in older individuals, it also prolongs postoperative analgesia (p<0.001).…”

Section: Shraddha Et Al'smentioning

confidence: 99%

A Comparative Dose-Response Study Between Intrathecal Nalbuphine (0.8 Mg, 1.4 Mg) With Bupivacaine Heavy 0.5% 3.5 Cc in Lower Abdominal Surgeries

SOMASUNDHAAR S,

ADAPA

2023

Asian J Pharm Clin Res

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Aims: To study the efficacy of various doses of nalbuphine as an additive in sub-arachnoid block for lower abdominal surgeries. Methods: This comparative study was conducted by the addition of two different doses of nalbuphine as an adjuvant: 0.8 mg nalbuphine hydrochloride to 0.5% bupivacaine (heavy) and 1.4 mg nalbuphine hydrochloride to 0.5% bupivacaine (heavy), the onset, maximum level, duration of sensory blockade, motor blockade, and hemodynamic parameters were studied. Results: It was discovered that group B (1.4 mg of nalbuphine added to 0.5% bupivacaine [H]) results in a later onset and greater degree of sensory and motor blockage. This group also considerably extended the time of analgesia, sensory and motor blockage, and both. The statistical examination of the mean blood pressure and mean pulse rate, together with the study of hemodynamic parameters, revealed that the p value was significant for the mean pulse rate and diastolic blood pressure but negligible for the systolic blood pressure. Conclusion: It can be concluded that intrathecal 0.5% bupivacaine (H)+nalbuphine (1.4 mg) when compared to intrathecal 0.5% bupivacaine (H)+nalbuphine (0.8 mg) in the patients undergoing lower abdominal surgeries.

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A double-blind prospective randomised controlled clinical study comparing 0.5% hyperbaric bupivacaine with nalbuphine and 0.5% hyperbaric bupivacaine for spinal anaesthesia in lower limb orthopaedic surgeries

Divya¹,

Anand²,

Bagchi³

2022

Journal of Clinical and Scientific Research

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Background: Intrathecal nalbuphine is one such opioid, highly lipid soluble with an agonist action at the kappa and antagonist activity at the muopioid receptors, known cardiovascular stability, minimal dose and volume of this drug that can be added to a local anaesthetic agent. Methods: This prospective randomised double-blind study was conducted to evaluate the effects of adding nalbuphine to 0.5% hyperbaric bupivacaine in spinal anaesthesia to know the efficacy, duration of analgesia, incidence of side effects and complications. Sixty American Society of Anesthesiologists (ASA) grade I and II patients were randomly allocated to Group A and Group B of 30 each who received 0.4 mL (0.4 mg) of nalbuphine and 0.4 mL of normal saline added to 3 mL (15 mg) of 0.5% hyperbaric bupivacaine, respectively. Intraoperative haemodynamic parameters, onset, duration of sensory and motor block, visual analogue scale (VAS) score, duration of effective analgesia and possible side effects were monitored and compared. Results: There was no statistically significant difference in the haemodynamic parameters, onset of blockade, duration of motor blockade and side effects. However, in two-segment regression, time of sensory blockade, duration of effective analgesia and VAS scores in Group A were found statistically significantly higher (P < 0.001) compared to Group B. Conclusions: Intrathecal nalbuphine used as adjuvant to bupivacaine prolongs duration of effective analgesia, without any significant side effects with stable haemodynamic parameters.

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Cited by 3 publications

References 16 publications

A Comparison Between Intrathecal Nalbuphine and Dexmedetomidine as Adjuvants to Hyperbaric Bupivacaine for Lower Limb Orthopedic Surgeries

A Comparison Between Intrathecal Nalbuphine and Dexmedetomidine as Adjuvants to Hyperbaric Bupivacaine for Lower Limb Orthopedic Surgeries

A Comparative Dose-Response Study Between Intrathecal Nalbuphine (0.8 Mg, 1.4 Mg) With Bupivacaine Heavy 0.5% 3.5 Cc in Lower Abdominal Surgeries

A double-blind prospective randomised controlled clinical study comparing 0.5% hyperbaric bupivacaine with nalbuphine and 0.5% hyperbaric bupivacaine for spinal anaesthesia in lower limb orthopaedic surgeries

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