Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas

Abstract

Topical timolol maleate has recently gained popularity as a treatment for superficial infantile hemangiomas, but calculating a safe dose of timolol can be time consuming, which may limit the medication's use in fast-paced clinical environments. This report offers a simplified calculation of the maximum daily safe dosage as 1 drop of medication per kilogram of body weight.

Comment on “Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas”

“…We read with interest “Doing the math: A simple approach to topical timolol dosing for infantile hemangiomas.” Dalla Costa et al offered a simple method for calculating a safe maximum daily dose as equivalent to 1 drop of timolol 0.5% gel‐forming solution (GFS) per kilogram of body weight. Our concern is that, according to the proposed weight‐based formula, patients would be eligible to receive more than 2 drops for the majority of treatment duration, because treatment is typically intended to continue through the first year of life.…”

IADVL SIG pediatric dermatology (academy) recommendations on Hemangioma of Infancy (HOI)

“…suggested that a maximum safe dose of 1 drop/kg body weight of 0.5% timolol gel-forming solution can be used for topical application. [ 34 ] However, further studies are necessary before this dosage can be recommended. [ 35 ]…”