Dolabrane-Type Diterpenoid and Lignan Constituents From the Stem Barks of Ceriops Decandra (Griff.) W. Theob.

Linh, Kieu Thi Phuong; Chien, Nguyen Van; Trung, Nguyen Quoc; Thong, Vu Huy; Tuyen, Nguyen Van; Thảo, Nguyễn Phương

doi:10.15625/2525-2518/58/4/14711

JST

2020

DOI: 10.15625/2525-2518/58/4/14711

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Dolabrane-Type Diterpenoid and Lignan Constituents From the Stem Barks of Ceriops Decandra (Griff.) W. Theob.

Kieu Thi Phuong Linh

Nguyen Van Chien

Nguyen Quoc Trung

et al.

Abstract: Three dolabrane-type diterpenoids (1‒3) and a lignan derivative (4) were isolated from a methanolic extract of C. decandra stem barks using various chromatographic separations. Their structures were elucidated to be tagalsine X (1), tagalsin P (2), ent-5α,2-oxodolabr-3-ene-3,15,16-triol (3), and (+)-pinoresinol (4) by detailed analysis via spectroscopic techniques (1D, 2D NMR, and ESI-MS data) as well as comparison with those reported. This is the first report of compound 4 from the Ceriops genus.

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Cited by 3 publications

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Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

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Bhitarkanika National Park is the second largest contiguous mangrove forest of India. Approximately 0.15 million mangrove depending population are found residing in and around 307 villages within the National Park. Despite being one of the most diverse mangrove habitations of India, the ethnopharmacological practices are meager in comparison to the other mangrove regions of India and Southeast Asia. The present review is aimed to congregate information on the therapeutic potential and ethnopharmacology of nine dominant mangrove species of the National Park, such as Aegiceras corniculatum, Avicenia marina, Avicenia officinalis, Ceriops decandra, Excoecaria agallocha, Heritiera fomes, Lumnitzera racemosa, Rhizophora mucronata, and Sonneratia apetala. Our aim is to generate social awareness among the mangrove dwellers to promote uses of folklore medicine using these tremendously potential mangrove plants, as a complementary step to strengthen community health. Further, we also want to grab the attention of researchers working in related disciplines, for their holistic and extensive studies towards bio-prospectation of the dominant mangrove plants of Bhitarkanika National Park.

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Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

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Cytotoxic constituents from the stem barks of Ceriops decandra (Griff.) W. Theob.

Linh

Binh

Chien

et al. 2021

Vietnam Journal of Chemistry

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A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of five dolabrane‐ (1–5), and ent‐pimarane‐type diterpenoids (6) were isolated from the methanol extract of C. decandra (Griff.) W. Theob. stem barks, via various chromatographic separations. Their structures were elucidated to be ent‐5α,3,15‐dioxodolabr‐1,4(18)‐diene‐2,16‐diol (1), tagalene I (2), ent‐5α,2,15‐dioxodolabr‐3‐ene‐3,16‐diol (3), tagalsin S (4), notolutesin H (5), and ent‐8,15R‐epoxypimaran‐16‐ol (6) by comprehensive analysis of spectroscopic data (1D, 2D NMR, and ESI‐MS data) as well as comparison with the previous literature. All of the isolates were evaluated for their cytotoxicity against human lung cancer (SK‐LU‐1), human hepatocellular carcinoma (HepG2), and human breast cancer (MCF‐7) cell lines. Compounds 2 and 6 exerted inhibitions toward three tumor cell lines (SK‐LU‐1, HepG2, and MCF‐7) with IC50 values between 5.63 and 11.70 μg/mL, while other compounds exhibited weak to moderate or no cytotoxic activities (IC50 > 20 μg/mL).

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Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

Biswas

Golder

Abid³

et al. 2021

Heliyon

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Introduction: Ceriops decandra (CD) and Ceriops tagal (CT) are two traditionally used mangrove plants widely distributed along the coastal areas of South Asia, Africa, South Pacific. In this study, we evaluated the diuretic potential of aerial roots of CD, CT and assessed the effectiveness of the plants' terpenoids enriched bioactive constituents against human carbonic anhydrase (hCA) enzyme through molecular docking. Materials and methods: Firstly, the acute toxicity of CD and CT was evaluated in mice. In vivo diuretic activity was then studied in mice and the volume of excreted urine was measured. The urine was further examined for pH, density and Na þ , K þ , Cl À concentrations. From this, the saluretic, natriuretic, kaliuretic and CAI (carbonic anhydrase inhibitory) activities were calculated. Finally, total terpenoid contents (TTC) of the plant extracts were quantified and the terpenoids previously reported from both CD and CT were docked against four hCA isoforms -hCAII, hCAIV, hCAXII and hCAXIV. Results: In the acute toxicity assessment, no sign of toxicity was found. In diuretic activity evaluation, both extracts displayed substantial increase in urine volume, with CD being at top. Concentrations of Na þ , K þ and Cl À were also upsurged at a high dose of treatment (500 mg/kg). Both extracts at 500 mg/kg dose demonstrated potent saluretic, natriuretic and CAI activity. The TTC of CD was significantly higher than CT. In molecular docking analysis, greater binding affinity against hCA isoforms was demonstrated by the terpenoids reported from CD. Conclusion: Aerial roots of both CD and CT possess substantial diuretic activity with an inhibitory effect on CA. Here, diuretic potential as well as the total terpenoid content of CD were much greater between the two.

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Dolabrane-Type Diterpenoid and Lignan Constituents From the Stem Barks of Ceriops Decandra (Griff.) W. Theob.

Cited by 3 publications

References 18 publications

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Cytotoxic constituents from the stem barks of Ceriops decandra (Griff.) W. Theob.

Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

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