Domain- and trimester-specific effect of prenatal phthalate exposure on preschooler cognitive development in the Ma’anshan Birth Cohort (MABC) study

Zhu, Yuanduo; Wu, Xiaoyan; Yan, Shuangqin; Huang, Kun; Tong, Juan; Gao, Hui; Xie, Yang; Tao, Shuman; Ding, Peng; Zhu, Peng

doi:10.1016/j.envint.2020.105882

Cited by 43 publications

(9 citation statements)

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“…At a mean age (SD) of 55.6 (6.9) months old, children’s cognitive development was assessed by using the Chinese version of Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-Ⅳ CN), which has high reliability and validity [ 21 , 22 ] and can be used in children aged 2.5–6 years. In detail, children aged 30–47 months ( n = 202) were required to complete 7 subtests to synthesize 4 indexes as verbal comprehension index (VCI, including information, receptive vocabulary and picture naming), visual space index (VSI, including block design and object assembly), working memory index (WMI, including picture memory and zoo locations) and full-scale intelligence quotient (FSIQ, calculated based on the above 3 indexes).…”

Section: Methodsmentioning

confidence: 99%

Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children’s Cognitive Development: A Birth Cohort Study

Hao

Yan

et al. 2022

Nutrients

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To investigate the joint effect of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on children’s cognitive development. We recruited 1685 mother–child pairs from the Ma’anshan Birth Cohort in China. Pre-pregnancy BMI and GWG were calculated based on the height and weights measured at multiple antenatal checkups. Children’s cognition was assessed by Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition. Poisson regression model was used to analyze the association between maternal pre-pregnancy BMI and children’s cognitive dimensions under different GWG categories. Women with overweight or obese before pregnancy were more likely to obtain excessive GWG. When women had excessive GWG, pre-pregnancy overweight was associated with low children’s PSI (OR = 1.69, 95%CI: 1.02–2.81) and pre-pregnancy obesity was related to poor VCI in children (OR = 3.71, 95%CI: 1.49–9.22), after adjusting for potential confounders. In pre-pregnancy underweight mothers, adequate GWG reduced the risk of below-average VSI in children (OR = 0.22, 95%CI: 0.05–0.92), but excessive GWG was related to low FSIQ in children (OR = 2.53, 95%CI: 1.34–4.76). In women with excessive GWG, maternal pre-pregnancy BMI displays an inverted U-shape association with children’s cognition. Moreover, adequate GWG in women with pre-pregnancy underweight was beneficial for children’s cognition.

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Section: Methodsmentioning

confidence: 99%

Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children’s Cognitive Development: A Birth Cohort Study

Hao

Yan

et al. 2022

Nutrients

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“…In humans, one major study of prenatal exposure to MBP ( 66 ) reported significant association with lower verbal comprehension and visual space indices in Chinese preschoolers and pointed to phthalate exposure in the first trimester as critical for cognitive development in children. Various markers of phthalate exposure across the gestation stage have been associated with lower frequency and higher amplitude of non-nutritive sucking on a pacifier among full-term infants as early signs of exposure-related changes in neurological function ( 67 ).…”

Section: Toxicitymentioning

confidence: 99%

Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions

Šimunović

Tomić

Kranjčec

2022

Archives of Industrial Hygiene and Toxicology

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Phthalates are a group of phthalic acid esters used as plasticisers in a large number of products to improve their flexibility, softness, and extensibility. Their wide use in medical devices, however, raises a lot of concern, as they can enter the organism and have toxic effects on human liver, thyroid, kidneys, lungs, reproductive, endocrine, nervous, and respiratory system and are associated with asthma, obesity, autism, and diabetes. The aim of this review is to summarise current knowledge about phthalate migration from medical devices during different medical procedures and possible impact on patient health. It also looks at alternative plasticisers with supposedly lower migration rates and safer profile. Not enough is known about which and how many phthalates make part of medical devices or about the health impacts of alternative plasticisers or their migration rates.

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“…Up to 19 postnatal visits were conducted for mothers and their 3,273 singleton live births. Detailed procedures of the enrollment, follow-up, and biological sample collection of mother-child pairs are described elsewhere (20). The study protocol was approved by the Ethics and Research Committees of Anhui Medical University (Ref.…”

Section: The Mabc Studymentioning

confidence: 99%

Sex Discrepancy Observed for Gestational Metabolic Syndrome Parameters and Polygenic Risk Associated With Preschoolers’ BMI Growth Trajectory: The Ma’anshan Birth Cohort Study

et al. 2022

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BackgroundFew studies have investigated the associations of childhood growth trajectories with the prenatal metabolic risks of mothers and their interaction with children’s genetic susceptibility.ObjectiveTo investigate the effects of gestational metabolic syndrome (GMS) risks and children’s polygenic risk scores (PRSs), and their interaction effect on the BMI trajectory and obesity risk of offspring from birth to 6 years of age.MethodsA total of 2,603 mother-child pairs were recruited from the Ma’anshan birth cohort (Anhui Province of China) study. Data on maternal prepregnancy obesity, gestational weight gain (GWG), gestational diabetes mellitus (GDM), and hypertensive disorders of pregnancy (HDP) were used to evaluate maternal GMS risk. In addition, 1,482 cord blood samples were used to genotype 11 candidate single-nucleotide polymorphisms (SNPs) to calculate children’s PRSs. The latent class growth model using the longitudinal BMI-for-age z scores (BMIz) was applied to validly capture the BMIz growth trajectory.ResultsMaternal GMS status was associated with higher BMIz scores and with an increased risk of overweight/obesity. Positive relationships were revealed between PRS and the risk of overweight/obesity among girls. Additionally, maternal GMS significantly interacted with the child’s PRS on BMIz scores and the risk of overweight/obesity among girls. Hierarchical BMI trajectory graphs by different exposure groups showed consistent findings, and both boys’ and girls’ BMIz trajectories were divided into three groups. Among girls, the higher the GMS risk or PRS they had, the higher the probability of being in the high BMIz trajectory group.ConclusionsMaternal GMS status increased BMIz scores and the risk of obesity in both boys and girls and elevated the child’s BMI trajectory from birth to 6 years of age among girls. PRSs were significantly associated with children’s BMI trajectory and the risk of obesity and modified the associations between maternal GMS status and obesity biomarkers only among girls. Thus, regarding childhood obesity, steps should be taken to decrease maternal metabolic risks before and during pregnancy, and sex discrepancies should be noted to identify high-risk populations after birth to hierarchically manage them.

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Domain- and trimester-specific effect of prenatal phthalate exposure on preschooler cognitive development in the Ma’anshan Birth Cohort (MABC) study

Cited by 43 publications

References 91 publications

Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children’s Cognitive Development: A Birth Cohort Study

Maternal Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Children’s Cognitive Development: A Birth Cohort Study

Medical devices as a source of phthalate exposure: a review of current knowledge and alternative solutions

Sex Discrepancy Observed for Gestational Metabolic Syndrome Parameters and Polygenic Risk Associated With Preschoolers’ BMI Growth Trajectory: The Ma’anshan Birth Cohort Study

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