2022
DOI: 10.1101/2022.04.27.489784
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Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2

Abstract: Guanylate-binding proteins (GBPs) are a group of interferon-inducible GTPases that are essential components of cell-autonomous immunity against intracellular pathogens. They restrict the replication of intracellular pathogens by targeting and lysing the membrane of the pathogen-containing vacuole. The aim of our work is to provide a molecular-level understanding of how the GBPs destroy the parasitophorous vacuole membrane. To this end, we use molecular dynamics (MD) simulations to elucidate the domain motions … Show more

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Cited by 3 publications
(22 citation statements)
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“…Before establishing dimer models of the three GBPs under investigation, we compare the dynamics of their monomers, on the one hand to further elucidate possible differences between hGBP1, mGBP2, and mGBP7, and on the other hand to have the monomer dynamics as a reference for the dynamics of the proteins when being oligomerized. The dynamics of hGBP1 and mGBP2 was discussed in detail in our previous works, 22,23 while the dynamics of mGBP7 is being unraveled in this study. In all three cases, Hamiltonian replica exchange molecular dynamics (HREMD) simulations were applied to the monomeric proteins.…”
Section: Molecular Dynamics Of Monomeric Gbpsmentioning
confidence: 70%
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“…Before establishing dimer models of the three GBPs under investigation, we compare the dynamics of their monomers, on the one hand to further elucidate possible differences between hGBP1, mGBP2, and mGBP7, and on the other hand to have the monomer dynamics as a reference for the dynamics of the proteins when being oligomerized. The dynamics of hGBP1 and mGBP2 was discussed in detail in our previous works, 22,23 while the dynamics of mGBP7 is being unraveled in this study. In all three cases, Hamiltonian replica exchange molecular dynamics (HREMD) simulations were applied to the monomeric proteins.…”
Section: Molecular Dynamics Of Monomeric Gbpsmentioning
confidence: 70%
“…Using bioinformatic/phylogenetic methods, seven human GBPs (hGBP1 to hGBP7) and 11 murine GBPs (mGBP1 to mGBP11) have been identified. 15,21 In this work, we will concentrate on hGBP1, mGBP2, and mGBP7, continuing our previous studies of hGBP1, 22 mGBP2, 23 and mGBP7. 24 The GBPs exhibit three domains (Fig.…”
Section: Introductionmentioning
confidence: 93%
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