Domain-specific cognitive impairment in patients with COPD and control subjects

Cleutjens, Fiona; Franssen, Frits; Spruit, Martijn A.; Vanfleteren, Lowie E.G.W.; Gijsen, Candy; Dijkstra, Jeanette; Ponds, Rudolf; Wouters, Emiel F.M.; Janssen, Daisy

doi:10.1183/13993003.congress-2016.pa3742

Cited by 4 publications

(8 citation statements)

References 31 publications

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“…Indeed, in COPD patients without any comorbidities on the Charlson index compared to controls without COPD and other comorbidities on the Charlson index, worse scores for cognitive flexibility and planning, but not for lower order cognitive functions such as psychomotor speed and memory, have been demonstrated. 3…”

Section: Discussionmentioning

confidence: 99%

“…9 Moreover, 90 patients were part of a previous publication on the prevalence of general and domain-specific CI between patients with COPD and non-COPD controls. 3…”

Section: Methodsmentioning

confidence: 99%

“…2 Furthermore, psychological problems, such as symptoms of depression and anxiety, and cognitive impairment (CI), are common in patients with COPD. 2,3…”

mentioning

confidence: 99%

“…Patients with COPD can have either global impairment or deficits in specific cognitive domains, such as memory or cognitive flexibility. 3 Impairment in memory and cognitive flexibility may lead to problems with adherence to treatment, educational achievement, self-management, and smoking abstinence, 4 –7 which are components of pulmonary rehabilitation (PR). 8…”

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confidence: 99%

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Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

et al. 2017

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We aimed to investigate (1) the relationship between cognitive impairment (CI) and disease severity and (2) the potential differences in exercise performance, daily activities, health status, and psychological well-being between patients with and without CI. Clinically stable chronic obstructive pulmonary disease (COPD) patients, referred for pulmonary rehabilitation, underwent a neuropsychological examination. Functional exercise capacity (6-minute walk test [6MWT]), daily activities (Canadian Occupational Performance Measure [COPM]), health status (COPD Assessment Test [CAT]) and St George’s Respiratory Questionnaire-COPD specific [SGRQ-C]), and psychological well-being (Hospital Anxiety and Depression Scale [HADS], Beck Depression Inventory [BDI], and Symptom Checklist 90 [SCL-90]) were compared between patients with and without CI. Of 183 COPD patients (mean age 63.6 (9.4) years, FEV1 54.8 (23.0%) predicted), 76 (41.5%) patients had CI. The prevalence was comparable across Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1–4 (44.8%, 40.0%, 41.0%, 43.5%, respectively, p = 0.97) and GOLD groups A–D (50.0%, 44.7%, 33.3%, 40.2%, respectively, p = 0.91). Patients with and without CI were comparable for demographics, smoking status, FEV1% predicted, mMRC, 6MWT, COPM, CAT, HADS, BDI, and SCL-90 scores. Clinical characteristics of COPD patients with and without CI are comparable. Assessment of CI in COPD, thus, requires an active case-finding approach.

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Section: Discussionmentioning

confidence: 99%

“…9 Moreover, 90 patients were part of a previous publication on the prevalence of general and domain-specific CI between patients with COPD and non-COPD controls. 3…”

Section: Methodsmentioning

confidence: 99%

“…2 Furthermore, psychological problems, such as symptoms of depression and anxiety, and cognitive impairment (CI), are common in patients with COPD. 2,3…”

mentioning

confidence: 99%

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confidence: 99%

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Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

et al. 2017

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“…They found a prevalence rate of 56.7% for general cognitive impairment, which meant four times higher compared to matched non-COPD controls. The most prevalent afected domains were planning and cognitive lexibility, where abnormal planning was observed in 16.7% of patients without comorbidities but in none of the controls without comorbidities, and abnormal cognitive lexibility was observed in 44.4 and 11.6% of patients and controls without comorbidities, respectively [9].…”

Section: Copd: Fundamental Pathophysiological Mechanisms Susceptible mentioning

confidence: 97%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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Mild cognitive impairment (MCI), also known as incipient dementia, is characterized by the decline of cognitive function greater than expected for a certain age and educational level of the individual but not severe enough to interfere with their daily activities. However, this mild cognitive impairment afects several areas: visuospatial, memory, atention and luency and it is a signiicant concern because it decreases the quality of life and treatment adherence of these patients. On the other hand, evidence suggests that individuals with Chronic obstructive pulmonary disease (COPD) also present an important risk of falls: 46% of these patients experience a fall/year, sometimes with fatal consequences. Standard clinical balance measures can predict the risk of falls in this population. Moreover, increased inlammatory biomarkers are associated with the decrease of cognitive functions and a higher risk of falls in this population. Patients with COPD have a higher balance and cognitive impairment than their healthy peers Therefore, it is important to identify, assess and understand the relevance of these comorbidities in order to characterize the full clinical spectrum of COPD and adjust prevention strategies, given the devastating consequences of these problems.

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The effect of dyspnea on recognition memory

Sucec

Herzog

Bergh

et al. 2020

International Journal of Psychophysiology

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Dyspnea is a debilitating symptom in various prevalent diseases. Previous research demonstrated several cognitive impairments in dyspneic patients including an impairment in recognition memory. Even though some factors contributing to these impairments have already been identified (e.g., smoking, medication), the relevance of dyspnea as one of those contributing factors is still unclear. Thus, the goal of the current study was to investigate whether acute dyspnea impairs recognition memory in a picture recognition task as indexed by reduced accuracy and a reduced old-new effect in event-related potentials (ERPs) in the electroencephalogram (EEG). Fifty healthy participants underwent a passive encoding phase without dyspnea induction, followed by the picture recognition task performed during an unloaded baseline and a resistive load induced dyspnea condition while EEG was continuously measured. Results indicated comparable accuracy during the baseline and dyspnea condition. A reduced fronto-central old-new effect during dyspnea compared to baseline was found for ERPs in the latency ranges 350-500, 500-800, 800-1100, and 1110-1400 ms. These findings suggest that dyspnea influences the process of familiarity (350-500 ms) and recollection (500-800 ms) as well as post-retrieval processes (800-1100 and 1100-1400 ms), highlighting a potential impairing effect of acute dyspnea on recognition memory.

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Domain-specific cognitive impairment in patients with COPD and control subjects

Cited by 4 publications

References 31 publications

Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

Neurocognitive Impairment as Systemic Effects of COPD

The effect of dyspnea on recognition memory

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