Domains of Daily Physical Activity in Children with Mitochondrial Disease: A 3D Accelerometry Approach

Abstract

Feasible, sensitive and clinically relevant out-

Monitoring daily physical activity of upper extremity in young and adolescent boys with Duchenne muscular dystrophy: A pilot study

“…Evaluating UE function in the home setting with sensors will give better insights into daily functioning at home. Our finding that accelerometry can be used as an objective outcome measurement correlates with findings in studies of patients with different diagnoses and with findings from studies for lower extremity function in DMD …”

“…Currently, diaries are widely used; however, they are time consuming for patients, subjective, and, therefore, probably less reliable . Accelerometers could provide a more objective measure …”

“…Intensity (or movement counts) of movement was recommended as a parameter in several studies . Koene et al questioned the relationship between measured intensity and UE function in children with mitochondrial disease because a high level of nonpurposeful activity influences the registration of the parameter intensity. However, this specifically applies to children with movement disorders such as ataxia.…”

“…However, this specifically applies to children with movement disorders such as ataxia. Other mentioned parameters are the duration of arm use in combination with a jerk index, level of arm elevation, mean of rotation rate, and elevation rate . The objective of this pilot study was to evaluate the validity of three acceleration‐based parameters on UE activity in at‐home situations as an outcome measure in ambulant and wheelchair dependent boys/adolescents with DMD.…”

International Workshop:

“…Feasibility and face validity of 3D accelerometry has recently been established in children with mitochondrial disease, of which some had PMM [58]. For certain PMM patients with gait abnormalities, the use of the GAITRite computerized system was endorsed as an objective assessment of gait.…”