Domains of Structured Oral Anticancer Medication Programs: A Scoping Review

Sivakumaran, Kapeena; Ginex, Pamela; Waseem, Haya; Belcher, Sarah M.; Lagler-Clark, Sarah; LeFebvre, Kristine B.; Palmer, Nicole; Pasumarthi, Tejanth

doi:10.1188/22.onf.296-306

Cited by 2 publications

(2 citation statements)

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“…A recent review retrieved from the literature that most of the OAA adherence programmes were pharmacy or clinic-based, and dedicated to the initiation and/or implementation phase of OAA therapy. 14 The ONCORAL programme is based on the components known to influence adherence to OAA, such as education, counselling, monitoring of adverse events, and drug–drug interactions, adherence follow-up, and a dedicated staff member to be contacted. 32 All sessions are scheduled following a medical consultation with the hospital oncologist, so that patients do not have to return specifically to the hospital, thus reducing the burden.…”

Section: Discussionmentioning

confidence: 99%

“…11 Finally, such medication management contributes to the optimal effectiveness of the treatment and a better quality of life. 12 13 Structured OAA programmes have been set up in different countries and described in the literature, based on different components and organisation, 14 highlighting the follow-up and monitoring of patients throughout their treatment. 15 A promising effect has been described in the literature for certain adherence enhancing interventions, applied to target one or multiple factors influencing patient behaviour.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

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Cost-effectiveness of the ONCORAL multidisciplinary programme for the management of outpatients taking oral anticancer agents at risk of drug-related event: protocol for a pragmatic randomised controlled study

Huot,

Guerre,

Descotes

et al. 2024

BMJ Open

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IntroductionThe development of oral anticancer agents (OAA) has profoundly changed cancer care, leading patients to manage their chemotherapy treatment on an outpatient basis. The prevention of iatrogenic effects of OAA remains a major concern, especially since their side effects are not less serious than those of intravenous chemotherapy. The ONCORAL programme was set up to secure the management of OAA in cancer patients followed at the Lyon University Hospital. This multidisciplinary programme involves hospital pharmacists, nurses, oncologists, and haematologists, as well as community health professionals. Given the economic stakes that this programme entails for the health system, a medico-economic study was designed.Methods and analysisThis is a prospective controlled study, with individual open-label randomisation. A total of 216 outpatients treated with OAA and at risk of developing a drug-related iatrogenic event, will be randomised (2:1) to undergo follow-up in the ONCORAL programme or usual care. The primary outcome will be the estimation of the incremental cost-effectiveness ratio (difference in total costs per quality adjusted life years gained) at 12 months between the two groups. The secondary outcomes will be evaluation of OAA management consequences (relative-dose intensity, adherence, adverse drug events, drug–drug interactions, and proven medication errors), evaluation of overall survival and cancer-related quality of life, and patient-reported outcomes in relation to the treatment. A budget impact analysis will be implemented. Patient and health professional satisfaction regarding the ONCORAL programme will be measured.Ethics and disseminationApproval to conduct this study was obtained from an Ethics Committee (Comité de Protection des Personnes Ile-de-France VI) in October 2019, and from the French data protection agency (Commission Nationale de l’Informatique et des Libertés), according to the French Law. Trial results will be disseminated at clinical conferences and published in peer-reviewed journals.Trial registrationNCT03660670.

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Section: Discussionmentioning

confidence: 99%