1995
DOI: 10.1002/jcb.240570312
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Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix

Abstract: Steroid receptors have been reported to bind to the nuclear matrix. The nuclear matrix is operationally defined as the residual nuclear structure that remains after extraction of most of the chromatin and all soluble and loosely bound components. To obtain insight in the molecular mechanism of the interaction of steroid receptors with the nuclear matrix, we studied the binding of several deletion mutants of the human androgen receptor (hAR) and the human glucocorticoid receptor (hGR) to the nuclear matrix. Rec… Show more

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Cited by 95 publications
(59 citation statements)
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“…NMTSs have been described for the transcription factors AML-1 (32), YY1 (33), PIT-1 (34), and other nuclear proteins such as the kinase anchoring protein AKAP95 (35), the EpsteinBarr virus nuclear antigen leader protein (EBNA-LP) (36), and the glucocorticoid receptor (37,38). No consensus sequence for these NMTSs has been found, and they have no significant similarity to the SRm160 NMTS.…”
Section: Discussionmentioning
confidence: 99%
“…NMTSs have been described for the transcription factors AML-1 (32), YY1 (33), PIT-1 (34), and other nuclear proteins such as the kinase anchoring protein AKAP95 (35), the EpsteinBarr virus nuclear antigen leader protein (EBNA-LP) (36), and the glucocorticoid receptor (37,38). No consensus sequence for these NMTSs has been found, and they have no significant similarity to the SRm160 NMTS.…”
Section: Discussionmentioning
confidence: 99%
“…F actors that mediate transcription, processing of gene transcripts, DNA replication, and DNA repair are organized as discrete domains within the nucleus (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The osteogenic and hematopoietic Runx transcription factors contain a unique and conserved amino acid motif in the C terminus designated the nuclear matrix targeting signal that directs Runx proteins to subnuclear foci where gene regulatory complexes are assembled in situ (14)(15)(16)(17)(18)(19)(20).…”
mentioning
confidence: 99%
“…I n the interphase nucleus, many tissue-restricted transcription factors are architecturally organized at punctate subnuclear sites that are associated with the nuclear matrix scaffold (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). These nuclear matrix-associated intranuclear foci are linked to transcriptional activation and suppression and contain coregulatory proteins and signaling molecules (19-22, ‡).…”
mentioning
confidence: 99%