Domestic and Wild Bird Models for the Study of Aging

Holmes, Donna J.; Ottinger, Mary Ann

doi:10.1016/b978-012369391-4/50031-x

Cited by 6 publications

(5 citation statements)

References 98 publications

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“…Furthermore, investigations of telomeres and telomerase reveal similar age-related changes to those observed in mammals, suggesting that this measure is important as a comparison of the long-and short-lived birds (Haussmann et al, 2003;O'Hare and Delany, 2005). However, relatively few studies of wild birds have specifically linked aging and neural systems (for review, see Holmes and Ottinger, 2005a). An enormous literature exists for songbirds, especially relative to the function and seasonal changes in the song control nuclei and the behavioural responses, and it is not our purpose to review this literature.…”

Section: Bioindicators Of Aging and Interventions That May Extend Lifmentioning

confidence: 99%

Neuroendocrine and immune characteristics of aging in avian species

Ottinger¹,

Lavoie²

2007

Cytogenet Genome Res

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Avian species show a remarkable diversity in lifespan. The differing lifespan patterns are found across a number of birds, in spite of higher body temperature and apparent increased metabolic rate. These characteristics make study of age-related changes of great interest, especially for understanding the biology of aging associated with surprisingly long lifespan in some birds. Our studies have focused on a short-lived avian model, the Japanese quail in order to describe reproductive aging and the neuroendocrine characteristics leading to reproductive senescence. Biomarkers of aging used in mammalian species include telomere length, oxidative damage, and selected metabolic indicators. These markers provide confirming evidence that the long-lived birds appear to age more slowly. A corollary area of interest is that of immune function and aging. Immune responses have been studied in selected wild birds and there has been a range of studies that have considered the effects of stress in wild and domestic species. Our laboratory studies have specifically tested response to immune challenge relative to aging in the quail model and these studies indicate that there is an age-related change in the qualitative aspects of the response. However, there are also intriguing differences in the ability of the aging quail to respond that differ from mammalian data. Finally, another approach to understanding aging is to attempt to develop or test strategies that may extend lifespan and presumably health. One area of great interest has been to consider the effect of calorie restriction, which is a treatment shown to extend lifespan in a variety of species. This approach is routinely used in domestic poultry as a means for extending reproductive function and enhancing health. Our data indicate that moderate calorie restriction has beneficial effects, and that physiological and endocrine responses reflect these benefits.

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Section: Bioindicators Of Aging and Interventions That May Extend Lifmentioning

confidence: 99%

Neuroendocrine and immune characteristics of aging in avian species

Ottinger¹,

Lavoie²

2007

Cytogenet Genome Res

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“…Direct evidence of limited follicular reserves is available for very few avian species 16, 51 . For aged chickens and domestic quail, there is both endocrinological and functional evidence of depletion of the ovarian reserve 52, 53 .…”

Section: Female Reproductive Aging In Phylogenetic Contextmentioning

confidence: 99%

“…Vertebrate animals exhibit a striking variety of reproductive aging patterns, [9][10][11][12][13][14][15][16][17][18][19][20][21][22] ranging from the dramatic and rapid declines in fertility seen in semelparous species, like migratory salmon and some mouse-sized marsupials, to the extremely slow or even negligible decreases in reproductive success documented for some seabirds, some reptiles (e.g., turtles), and some fishes (e.g., rockfish) ( Table 1). Markers of physiological senescenceincluding gonadal changes-are now documented in natural populations of a variety of birds and mammals, and there is demographic evidence consistent with aging-related reproductive declines in females from a much wider range of vertebrate taxa than generally recognized, including some fishes.…”

Section: Female Reproductive Aging In Phylogenetic Contextmentioning

confidence: 99%

“…However, most documented patterns of avian reproductive aging are characterized by gradual to slow senescence, versus the extremely slow to negligible fertility loss seen in some fishes and reptiles. 16,18,19,49 While some data are available for wild birds maintained in captivity, most information on avian reproductive senescence come from banding and monitoring studies of wild bird populations. Much less is known for birds than mammals about the comparative prevalence or length of avian PRLS.…”

Section: Birdsmentioning

confidence: 99%

“…Direct evidence of limited follicular reserves is available for very few avian species. 16,51 For aged chickens and domestic quail, there is both endocrinological and functional evidence of depletion of the ovarian reserve. 52,53 Random counts of primordial follicles in Japanese quail showed significant declines (to below 35% of original numbers of primordial follicles) in the ovarian reserve in newly postreproductive Japanese quail hens, 54 relative to young (peak egg production) and middle-aged layers (Holmes, Wu, and Ottinger, unpublished data).…”

Section: Birdsmentioning

confidence: 99%

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Ovarian aging in developmental and evolutionary contexts

Finch

Holmes

2010

Annals of the New York Academy of Sciences

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Evolutionary theory predicts that aging-related fertility declines result from tradeoffs between reproduction and somatic maintenance. Developmental programs for oogenesis also contribute to variation in aging-related reproductive declines among female vertebrates. Documented reproductive aging patterns in female vertebrates, including humans, are consistent with canonical aging patterns determined developmentally and require no special adaptive explanation. Here we discuss patterns of aging-related ovarian decline in diverse female vertebrates, and place human ovarian aging in comparative context. Depletion of finite oocyte stores accompanied by fertility loss occurs in a variety of nonhuman mammals and vertebrates, including short-lived rodents, birds, and some fishes; moreover, postreproductive lifespans of considerable length clearly are not limited to long-lived, social species with well-developed kin networks. We argue for a more rigorous comparative approach for understanding the evolutionary and developmental bases of ovarian aging in vertebrates with a wider range of aging patterns and social structures.

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Neuroendocrine aging in birds: Comparing lifespan differences and conserved mechanisms

Ottinger

2007

Ageing Research Reviews

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Domestic and Wild Bird Models for the Study of Aging

Cited by 6 publications

References 98 publications

Neuroendocrine and immune characteristics of aging in avian species

Neuroendocrine and immune characteristics of aging in avian species

Ovarian aging in developmental and evolutionary contexts

Neuroendocrine aging in birds: Comparing lifespan differences and conserved mechanisms

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