Domestic cats and dogs are susceptible to H9N2 avian influenza virus

Zhang, Kun; Zhang, Zhaowei; Yu, Zhijun; Li, Lin; Cheng, Kaihui; Wang, Tiecheng; Geng, Hao; Wang, Cuiling; Zhao, Yongkun; Feng, Na; Fu, Jun; Qin, Chuan; Gao, Yuwei; Xia, Xianzhu

doi:10.1016/j.virusres.2013.04.004

Cited by 60 publications

(49 citation statements)

References 43 publications

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“…Since the first isolation from terrestrial birds (quails) in 1988, H9N2 became prevalent in China and, occasionally, infected a wide range of species, including humans, dogs, cats, pigs, and a wide variety of domesticated birds (Peiris et al, 1999;Xu et al, 2004;Bi et al, 2010;Zhang et al, 2013). It has been reported that H9N2 might provide internal genes to the lethal 1997 Hong Kong H5N1 viruses that caused six fatal cases out of 18 infected patients (Guan et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Wang¹,

Li²,

Diao³

et al. 2014

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Summary. -As the major aquatic and terrestrial hosts for avian influenza viruses (AIVs), ducks and chickens play a critical role in the evolution and spread of the H9N2 virus. However, the outcomes of infection of ducks and chickens with the H9N2 virus are not sufficiently documented. In this study, we compared the outcomes of infection of chickens and Peking ducks with a duck-origin H9N2 virus. The results showed that this virus caused more pronounced clinical signs and histological lesions in chickens. As for the virus shedding, chickens shed more virus in the trachea and less virus in the cloaca in levels of interferon (IFN) γ were found in the trachea of ducks compared with chickens, while comparison with ducks. As for cytokines, namely IFNs and interleukins (IL), higher higher levels of IFN-β, IFN-γ, IL-1β, and IL-6 were observed in the ileum of chickens compared with ducks. Eventually, serum hemagglutination-inhibition (HI) antibody titers were higher in chickens than in ducks. Taken together, ducks and chickens use different strategies in response to the H9N2 virus infection in tissues representing main replication sites of low-pathogenic AIVs. Given the different outcomes of the H9N2 virus infection in ducks and chickens, different measures should be taken in vaccination and treatment.Keywords: duck-origin influenza A virus; H9N2 subtype; chicken; duck * Corresponding author. E-mail: yxdiao@126.com; phone: +86 0538 8249851-8210.# These authors contributed equally to this work. Abbreviations: AIV(s) = avian influenza virus(es); CL = cloacal; HA = hemagglutinin; HI = hemagglutination-inhibition; HPAIVs = highly pathogenic avian influenza viruses; IFN = interferon; IL = interleukin; LPAIV(s) = low pathogenic avian influenza virus(es); NA = neuraminidase; OP = oropharyngeal; p.i. = post infection

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Section: Introductionmentioning

confidence: 99%

Different outcomes of infection of chickens and ducks with a duck-origin H9N2 influenza A virus

Wang¹,

Li²,

Diao³

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Under the same condition, IAV Subtype H3N2 and H9N2 rapidly spread in cat population (Giese et al, 2008;Zhang et al, 2013).…”

Section: Epidemiologymentioning

confidence: 96%

“…Experimental evidence showed that influenza H9N2 virus can be recovered from intranasally inoculated cat. Also, intraspecies transmission of this subtype has been reported (Zhang et al, 2013) 6. DIAGNOSIS a.…”

Section: Influenza Virus H9n2mentioning

confidence: 98%

“…Also, it has been experimentally proven that interspecies transmission of H1N1/2009 among dogs is low (Lin et al, 2012). Amirsalehy et al, 2012;Sun et al, 2013;Zhang et al, 2013;Zhou et al, 2015a ;Zhou et al, 2015b ii. Avian-Origin Canine Influenza Virus H3N2 In South Korea, there was an outbreak of CIV H3N2 with severe respiratory diseases between May to September 2007 (Song et al, 2008).…”

Section: Influenza a Virus Subtypes In Dog And Catmentioning

confidence: 99%

“…Infected dog present mild clinical signs including weak, coughing, sneezing, nasal discharge, mild pyrexia, appetite and vomiting. However, infection may be subclinical (Sun et al, 2013;Zhang et al, 2013 (Sponseller et al, 2010). This cat was reported to develop respiratory difficulties some days after its close human family members had influenza-like illness.…”

Section: Avian-like H9n2mentioning

confidence: 99%

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