Domestic exposure to irritant cleaning agents and asthma in women

Lemire, Pierre; Dumas, Orianne; Chanoine, Sébastien; Temam, Sofia; Severi, Gianluca; Boutron‐Ruault, Marie‐Christine; Zock, Jan‐Paul; Siroux, Valérie; Varraso, Raphäelle; Moual, Nicole Le

doi:10.1016/j.envint.2020.106017

Cited by 35 publications

(52 citation statements)

References 34 publications

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“…Using the questionnaire, associations with the asthma symptom score were consistent with previous studies for sprays [6][7][8]20], bleach [6] and number of irritants [15]. Taking into account the number of irritants used is recent, and the previous study on the French elderly E3N cohort [15] (women in average, 70 years old), observed positive associations between the number of irritant HDCPs and current asthma similar to our study.…”

Section: Discussionsupporting

confidence: 91%

“…Participants reported their HDCP use over the last 3 months preceding the data collection times (T1, T3, M2; see Supplementary Materials, Figure S1), using online standardized questionnaires. Frequency of weekly use of HDCPs was reported in four classes (never, less than once a week, 1-3 days per week, 4 to 7 days per week (daily use)), as done in previous surveys [6,15]. In the online questionnaires, frequency was recorded for a limited amount of HDCP categories (spray, irritants, bleach, scented products).…”

Section: Methodsmentioning

confidence: 99%

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Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms

Lemire

Temam²,

Lyon-Caen³

et al. 2021

IJERPH

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Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms

Lemire

Temam²,

Lyon-Caen³

et al. 2021

IJERPH

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“…Repeated exposures to cleaning and disinfectant agents such as detergents and quaternary ammonium compounds, as are experienced every working day by cleaning personnel, are linked epidemiologically to asthma in adults, especially when the agents are used as sprays. 43 These agents are not only toxic to cells, 39 but they also increase epithelial permeability. 44 Moreover, many products contain potential allergens such as enzymes, so that exposure to these agents may increase the risk of allergic responses not only to extraneous allergens but also to the allergens contained within the product itself.…”

Section: Direct Effects Of Cleaning Products On Human Health?mentioning

confidence: 99%

Microbial exposures that establish immunoregulation are compatible with targeted hygiene

Rook

Bloomfield

2021

Journal of Allergy and Clinical Immunology

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It is often suggested that hygiene is not compatible with the microbial exposures that are necessary for establishment of the immune system in early life. However, when we analyze the microbial exposures of modern humans in the context of human evolution and history, it becomes evident that whereas children need exposure to the microbiotas of their mothers, other family members, and the natural environment, exposure to the unnatural microbiota of the modern home is less relevant. In addition, any benefits of exposure to the infections of childhood within their household setting are at least partly replaced by the recently revealed nonspecific effects of vaccines. This article shows how targeting hygiene practices at key risk moments and sites can maximize protection against infection while minimizing any impact on essential microbial exposures. Moreover, this targeting must aim to reduce direct exposure of children to cleaning agents because those agents probably exert T H 2-adjuvant effects that trigger allergic responses to normally innocuous antigens. Finally, we need to halt the flow of publications in the scientific literature and the media that blame hygiene for the increases in immunoregulatory disorders. Appropriately targeted hygiene behavior is compatible with a healthy lifestyle that promotes exposure to essential microorganisms.

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“…[15][16][17][18] An increasing number of studies suggest that respiratory effects of DCP are not restricted to populations with high exposure level at work, but are also observed in relation to common household exposures. 14,19,20 Use of DCP at home, in particular cleaning sprays and irritant products, has been associated with asthma incidence, 21,22 current asthma, or asthma symptoms, [23][24][25] and more recently with lung function decline. 19 To our knowledge, only one study examined the association between DCP exposure at home and asthma control.…”

Section: Introductionmentioning

confidence: 99%