Domestically acquired hepatitis E successfully treated with ribavirin in an Australian liver transplant recipient

Speers, David; Xiang, Michael; Faddy, Helen M.; Nash, Monica; Bowden, Scott; Boer, Bastiaan de; MacNicholas, Ross; MacQuillan, Gerry; Adams, Leon A.

doi:10.5694/mja14.00453

Cited by 13 publications

(17 citation statements)

References 9 publications

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“…It is believed that many of this cluster ate at a popular restaurant in Sydney (personal communication) with the source, in the case we describe, being pork pâté. While sporadic cases may occur, this is to our knowledge the first known outbreak of locally acquired HEV.…”

Section: The Patient's Liver Function Tests At Diagnosis and 1 Month mentioning

confidence: 74%

Local outbreak of hepatitis E: a rare cause of viral hepatitis in Australia

Pokorny

2015

Internal Medicine Journal

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Hepatitis E is a not uncommon cause of viral hepatitis globally but is relatively rare in Australia. Here, we report a case of acute hepatitis E that was acquired in Sydney and was part of a cluster believed to be infected locally. This is to our knowledge the first known outbreak of locally acquired hepatitis E in Australia. We discuss pathogenesis, clinical features and means by which further spread of infection can be limited.

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Section: The Patient's Liver Function Tests At Diagnosis and 1 Month mentioning

confidence: 74%

Local outbreak of hepatitis E: a rare cause of viral hepatitis in Australia

Pokorny

2015

Internal Medicine Journal

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“…The re-emergence of a disease refers to an increase in incidence of a disease that had previously declined (5 A case of locally-acquired HEV has been reported in an Australian liver transplant recipient, who also received blood transfusion (83). However, there was insufficient evidence to determine the mode of transmission.…”

Section: Emerging Infectious Diseases and Blood Safetymentioning

confidence: 99%

“…24 HEV cases have been reported in NSW in 2014, all with no recent overseas travel history and likely to be linked to the consumption of undercooked pork (199)(200)(201). Domestically acquired HEV infection in Australia, associated with genotype 3, has recently been reported in a liver transplant recipient (83). Several possible modes of transmission were postulated, including via transplantation, blood transfusion, or through the consumption of contaminated food or water by the recipient.…”

Section: Locally-acquired Infection In Humansmentioning

confidence: 99%

“…18 of these cases were associated with an outbreak from a single restaurant (201). Recently a case of locally-acquired HEV was reported in a liver transplant recipient who had also received a blood transfusion (83). There was insufficient evidence to elucidate the exact route of transmission, however, it was postulated to include contaminated food or transfusiontransmission (83).…”

Section: Introductionmentioning

confidence: 99%

“…To date, there have been no published case reports of TT-HEV in Australia. A case of HEV genotype 3, thought to be associated with transfusion was reported, but there was insufficient evidence to determine the mode of transmission (83).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the risks posed by hepatitis E virus to blood supply safety

Shrestha¹

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Transfusion is an important field of clinical medicine, responsible for saving the lives of millions of people. However, concerns remain for patients' safety from adverse reactions and transfusion transmissible infections (TTIs). While risks from well-known TTIs (such as human immunodeficiency virus, human T-lymphotrophic virus, hepatitis B virus, hepatitis C virus and Treponema pallidum) have been reduced in developed nations, developing countries struggle to maintain the minimum screening requirements for these infections.

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Hepatitis E virus infection in liver transplant recipients: a descriptive literature review

Perisetti

Laoveeravat

Inamdar

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

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Hepatitis E virus infection has been recognized as a rising hepatotropic viral infection in the developing countries but overlooked in the developed countries, due to its lower prevalence. However, hepatitis E virus prevalence is on rise in the liver transplant recipients due to immunosuppression, which needs prompt recognition by healthcare practitioners. Hepatitis E virus infection is commonly believed to be transmitted via an animal host; but in the post-liver transplant patients, it can also be acquired via blood and blood products transfusion and autochthonous route. Previous studies have shown the significance of hepatitis E virus infection in post-liver transplant, as the patients at a high risk of progressing to chronic hepatitis and cirrhosis. Pediatric patients are at higher risk of hepatitis E virus infection post-liver transplant. Specific hepatitis E virus genotypes have the potential for greater severity. The clinical manifestation of hepatitis E virus can also present as extrahepatic features which need high level of suspicion for early recognition and treatment. Treatment options of hepatitis E virus range from immunosuppressive drug minimization, ribavirin therapy to novel direct-acting antiviral regimens. Herein, we aim to explore epidemiology, prevalence, risk factor, diagnosis, and management of hepatitis E virus infection giving special attention to liver transplant recipients.

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Domestically acquired hepatitis E successfully treated with ribavirin in an Australian liver transplant recipient

Cited by 13 publications

References 9 publications

Local outbreak of hepatitis E: a rare cause of viral hepatitis in Australia

Local outbreak of hepatitis E: a rare cause of viral hepatitis in Australia

Evaluating the risks posed by hepatitis E virus to blood supply safety

Hepatitis E virus infection in liver transplant recipients: a descriptive literature review

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