Domiciliation and sympatry of Triatoma maculata and Rhodnius prolixus, risk of Trypanosoma cruzi transmission in villages of Anzoátegui, Venezuela

Blohm, L.; Sousa, Leonardo De; Roschman-González, Antonio; Ferrer, Elizabeth; Morocoima, Antonio; Herrera, Leidi

doi:10.1007/s12639-021-01416-8

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Classically, R. prolixus and T. maculata are the vectors with the highest rates of infection by T. cruzi in the country (Añez et al 2020;López et al 2021). Domiciliation and sympatry of T. maculata and R. prolixus and the risk of transmission of T. cruzi in villages of Anzoátegui, a state close to the state of Monagas have been reported (Blohm et al 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Trypanosoma cruzi generally is transmitted to humans and other mammals through contact with the faeces of infected triatomines (Hemiptera, Reduviidae, Triatominae). The mode of transmission is prevalent in rural populations, where conductive conditions for vector reproduction and reservoir development exist, often characterized by elements like mud houses, thatched roofs and different types of palm (Morocoima et al 2010(Morocoima et al , 2018Blohm et al 2022). However, alternative routes of transmission include blood transfusion and oral ingestion.…”

Section: Introductionmentioning

confidence: 99%

“…In Venezuela, rises in the prevalence and oral transmission have been observed and Chagas disease is considered a risk for approximately 6 million people, who live in 198 municipalities, within a territory of 101,488 km 2 . Several studies have shown the presence of triatomines with high frequency in palm trees, which are distributed throughout a large part of the Venezuelan territory, in such, close contact between man and the vector of this parasitosis have been detected (Morocoima et al 2010(Morocoima et al , 2018Añez et al 2020; Blohm et al 2022).…”

Section: Introductionmentioning

confidence: 99%

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Parasitological and molecular characterization of Trypanosoma cruzi of triatomines and mammals from endemic areas for Chagas disease in Venezuela

Morocoima,

Herrera,

Rattia

et al. 2023

Parasitol Res

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It is estimated that 6-7 million people worldwide are infected with Trypanosoma cruzi, the parasite that causes Chagas disease. In Venezuela, Chagas disease remains a public health problem. In this work, T. cruzi isolates from six species of triatomines and mammals of the orders Didelphimorphia and Xenarthra, captured in rural communities of Monagas, underwent parasitological and molecular characterization. A total of 471 triatomines and 17 mammals were captured, with a natural infection rate of 41.4% and 70.6%, respectively. In the male NMRI mouse model used for parasitological characterization (Prepatent period, parasitemia curve, mouse mortality and tissular parasitism), T. cruzi isolates exhibited high lethality due to their pronounced virulence, irrespective of the parasite load in each mouse, resulting in a mortality rate of 75%. Among the vector isolates, in the mouse model only 2 out of 6 remained alive, while the rest perished during the evaluation. Conversely, the isolates from mammals proved fatal for all the inoculated mice. All isolates were identi ed as belonging to DTU TcI, based on the molecular markers as intergenic region of the miniexon, D7 divergent domain of the 24Sα rDNA, sizevariable domain of the 18S rDNA and hsp60-PCR-RFLP-EcoRV. This study demonstrates the presence of vectors and mammalian reservoirs naturally infected with T. cruzi in communities of Monagas, the 9th largest and 9th most populous state in Venezuela. This situation represents a neglected epidemiological problem demanding urgent attention and imperative health care intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parasitological and molecular characterization of Trypanosoma cruzi of triatomines and mammals from endemic areas for Chagas disease in Venezuela

Morocoima,

Herrera,

Rattia

et al. 2023

Parasitol Res

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“…In Colombia and Venezuela, synanthropic T. maculata may carry T . cruzi at high frequencies and are likely involved in Chagas disease transmission (Blohm et al, 2022; García‐Alzate et al, 2014; González‐Brítez et al, 2010; Lent & Wygodzinsky, 1979; Rodríguez‐Monguí et al, 2019). Although infection with T .…”

Section: Introductionmentioning

confidence: 99%

“…In the wild, T. maculata occupies arboreal ecotopes including trees, palms, and bird nests; some populations, however, have adapted to exploit peridomestic structures (with a preference for chicken coops) and can also infest houses (Abad-Franch et al, 2010;Abad-Franch & Gurgel-Gonçalves, 2021;Lent & Wygodzinsky, 1979). In Colombia and Venezuela, synanthropic T. maculata may carry T. cruzi at high frequencies and are likely involved in Chagas disease transmission (Blohm et al, 2022;García-Alzate et al, 2014;González-Brítez et al, 2010;Lent & Wygodzinsky, 1979;Rodríguez-Monguí et al, 2019). Although infection with T. cruzi has not been reported in T. maculata from Roraima, Brazil, local populations infest rural and urban dwellings and have bionomic characteristics (especially a very short feeding-to-defecation time), suggesting that the species might also transmit Chagas disease in this area (Abad-Franch et al, 2010;Ricardo-Silva et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Molecular and cytogenetic evidence for sibling species in the Chagas disease vector Triatoma maculata

Gómez-Palacio

Pita

Abad‐Franch

et al. 2022

Medical Vet Entomology

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Triatoma maculata (Hemiptera, Reduviidae, Triatominae) occurs across dry‐to‐semiarid ecoregions of northern South America, where it transmits Trypanosoma cruzi, causative agent of Chagas disease. Using 207 field‐caught specimens from throughout the species' range, mitochondrial(mt) DNA sequence data, and cytogenetics, we investigated inter‐population genetic diversity and the phylogenetic affinities of T. maculata. Mitochondrial DNA sequence analyses (cytb and nd4) disclosed a monophyletic T. maculata clade encompassing three distinct geographic groups: Roraima formation (Guiana shield), Orinoco basin, and Magdalena basin (trans‐Andean). Between‐group cytb distances (11.0–12.8%) were larger than the ~7.5% expected for sister Triatoma species; the most recent common ancestor of these T. maculata groups may date back to the late Miocene. C‐heterochromatin distribution and the sex‐chromosome location of 45S ribosomal DNA clusters both distinguished Roraima bugs from Orinoco and Magdalena specimens. Cytb genealogies reinforced that T. maculata is not sister to Triatoma pseudomaculata and probably represents an early (middle‐late Miocene) offshoot of the ‘South American Triatomini lineage’. In sum, we report extensive genetic diversity and deep phylogeographic structuring in T. maculata, suggesting that it may consist of a complex of at least three sibling taxa. These findings have implications for the systematics, population biology, and perhaps medical relevance of T. maculata sensu lato.

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Chagas Disease and Leishmaniasis, Sympatric Zoonoses Present in Human from Rural Communities of Venezuela

Ferrer,

Aguilar,

Viettri

et al. 2024

Acta Parasit.

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Domiciliation and sympatry of Triatoma maculata and Rhodnius prolixus, risk of Trypanosoma cruzi transmission in villages of Anzoátegui, Venezuela

Cited by 5 publications

References 29 publications

Parasitological and molecular characterization of Trypanosoma cruzi of triatomines and mammals from endemic areas for Chagas disease in Venezuela

Parasitological and molecular characterization of Trypanosoma cruzi of triatomines and mammals from endemic areas for Chagas disease in Venezuela

Molecular and cytogenetic evidence for sibling species in the Chagas disease vector Triatoma maculata

Chagas Disease and Leishmaniasis, Sympatric Zoonoses Present in Human from Rural Communities of Venezuela

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