Dominance behavior: A phylogenetic analysis in the mouse

Messeri, Patrizia; Eleftheriou, Basil E.; Oliverio, Alberto

doi:10.1016/0031-9384(75)90141-9

Cited by 47 publications

(18 citation statements)

References 20 publications

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“…The tube test was chosen to measure social dominance in mice [17]. Two mice of the same sex and different genotype were placed in the opposite ends of a 30×3.5 cm transparent plastic tube and released simultaneously.…”

Section: Methodsmentioning

confidence: 99%

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

et al. 2013

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CD73 (ecto-5’-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5′-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological functions at this location remain elusive. Here we found, using immunohistochemistry of wild-type and CD73 deficient mice, that CD73 is prominently expressed in the basal ganglia core comprised of striatum (caudate nucleus and putamen) and globus pallidus. Furthermore, meninges and the olfactory tubercle were found to specifically express CD73. Analysis of wild type (wt) and CD73 deficient mice revealed that CD73 confers the majority of 5’-nucleotidase activity in several areas of the brain. In a battery of behavioural tests and in IntelliCage studies, the CD73 deficient mice demonstrated significantly enhanced exploratory locomotor activity, which probably reflects the prominent expression of CD73 in striatum and globus pallidus that are known to control locomotion. Furthermore, the CD73 deficient mice displayed altered social behaviour. Overall, our data provide a novel mechanistic insight into adenosinergic signalling in brain, which is implicated in the regulation of normal and pathological behaviour.

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Section: Methodsmentioning

confidence: 99%

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

et al. 2013

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“…Experts suggest laboratory studies with rodents mirror at least some aspects of aggression in humans (156). Several behavioral tests assess aggression in rodents, including the tube test (157) and the standard opponent method (158). However, the most widely employed assessment is the resident-intruder test (159).…”

Section: Post Injury Symptoms In Animal Models Of Tbimentioning

confidence: 99%

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Malkesman¹,

Tucker²,

Ozl³

et al. 2013

Front. Neurol.

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Each year in the US, ∼1.5 million people sustain a traumatic brain injury (TBI). Victims of TBI can suffer from chronic post-TBI symptoms, such as sensory and motor deficits, cognitive impairments including problems with memory, learning, and attention, and neuropsychiatric symptoms such as depression, anxiety, irritability, aggression, and suicidal rumination. Although partially associated with the site and severity of injury, the biological mechanisms associated with many of these symptoms – and why some patients experience differing assortments of persistent maladies – are largely unknown. The use of animal models is a promising strategy for elucidation of the mechanisms of impairment and treatment, and learning, memory, sensory, and motor tests have widespread utility in rodent models of TBI and psychopharmacology. Comparatively, behavioral tests for the evaluation of neuropsychiatric symptomatology are rarely employed in animal models of TBI and, as determined in this review, the results have been inconsistent. Animal behavioral studies contribute to the understanding of the biological mechanisms by which TBI is associated with neurobehavioral symptoms and offer a powerful means for pre-clinical treatment validation. Therefore, further exploration of the utility of animal behavioral tests for the study of injury mechanisms and therapeutic strategies for the alleviation of emotional symptoms are relevant and essential.

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“…Social dominance was assessed in the second week using the tube test [14, 15, 17]. On the day before testing each mouse was given three habituation sessions to become accustomed to the act of running into the tube.…”

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confidence: 99%

Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

Harrison

Hosseini

McDonald

2009

Behavioural Brain Research

341

245

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The effects of abnormally high or low stress on learning are well established. The Barnes maze and Morris water maze are two commonly-used tests of spatial memory, of which the water maze is considered more stressful; however, until now this has not been demonstrated empirically. In the present study, mice matched for performance on commonly-used anxiety tasks were trained on either the Barnes maze or water maze or received no cognitive testing. Water-maze training induced greater increases in plasma corticosterone than did Barnes maze training, assessed 30 min. after the final session. Importantly, spatial learning was inversely correlated with corticosterone levels in the water maze but not the Barnes maze, suggesting that performance on the water maze may be more affected by test-induced stress even within wild-type subjects of the same age and gender. These findings are important when considering the appropriate cognitive tasks for any experiment in which stress responses may differ systematically across groups. KeywordsAnxiety; stress; corticosterone; Barnes maze; Morris water maze; Elevated plus maze; Light-dark activity; social dominance; behaviour The Barnes maze [3] and Morris water maze [19] are similar tasks in that they both measure the ability of a mouse to learn and remember the location of a target zone using a configuration of distal visual cues located around the testing area [11,23]. Both tasks rely on hippocampaldependent spatial reference memory and on the inherent tendencies of the subjects to escape from an aversive environment [2,27]. It has been suggested that the Barnes maze is less anxiogenic [13,21]; however, we know of no data that support this assumption.Innate anxiety and cognitive ability differ considerably among mouse strains [5,13,18] highlighting the fact that the selection of a background strain and the choice of behavioural Corresponding author: Fiona Harrison, PhD, Vanderbilt University, Division of Diabetes, Endocrinology & Metabolism, 7465 Medical Research Building IV, 2213 Garland Avenue, Nashville, TN, 37232-0475, Fiona.Harrison@Vanderbilt.edu, Phone: 615-936-1660, FAX: 615-936-1667. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The subjects were thirty 7-week-old male, C57BL/6J mice obtained from Jackson Laboratory (Bar Harbor, ME, USA; stock #000664) and left undisturbed for 1 week before testing began. Mice were housed five per cage until 1 day before testing in the Barnes or water maze, when mice were singly housed to eliminate any additional stress that may arise from test order within the cage as other mice are r...

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Dominance behavior: A phylogenetic analysis in the mouse

Cited by 47 publications

References 20 publications

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

Traumatic Brain Injury – Modeling Neuropsychiatric Symptoms in Rodents

Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks

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