Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

Bowers, Jolene R.; Driebe, Elizabeth M.; Nibecker, Jennifer L; Wojack, Bette R.; Sarovich, Derek S.; Wong, Ada Hang‐Heng; Brzoska, Pius; Hubert, Nathaniel; Knadler, Andrew; Watson, Lindsey M.; Wagner, David M.; Furtado, Manohar R.; Saubolle, Michael A.; Engelthaler, David M.; Keim, Paul

doi:10.1186/1471-2180-12-12

Cited by 31 publications

(35 citation statements)

References 44 publications

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“…One possibility for the mechanism is the production of fermentation metabolites such as ethanol and lactic acid that may be the actual causes of lifespan extension in the worm [73]. However, more recently, Gomez et al [74] showed that lactic acid produced by Q-less E. coli was not responsible for the life-span extension. Instead, they suggested that the survival rate of worms may be improved due to the delay in the colonization of the worm gut by respiratory-deficient bacteria as compared to the wild type bacteria.…”

Section: Other Micronutrientsmentioning

confidence: 99%

Worms, bacteria, and micronutrients: an elegant model of our diet

Yılmaz

Walhout

2014

Trends in Genetics

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Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial diet provide a relatively simple and genetically tractable model to study both direct and microbe-mediated effects of micronutrients. Recently, this model has been used to gain insight into the relationship between micronutrients, physiology and metabolism. In particular, two B-type vitamins, vitamin B12 and folate, have been studied in detail. Here we review how C. elegans and its bacterial diet provide a powerful interspecies systems biology model that facilitates the precise delineation of micronutrient effects and the mechanisms involved.

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Section: Other Micronutrientsmentioning

confidence: 99%

Worms, bacteria, and micronutrients: an elegant model of our diet

Yılmaz

Walhout

2014

Trends in Genetics

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“…QS is a method of social communication that enables bacteria to coordinate behavior of their community in a cell-density–dependent manner. QS systems rely on the synthesis of small signaling molecules (autoinducers), their passive diffusion or active transport across the cell envelope [11-13] and their receptor-mediated detection by members of the same species. In proteobacteria, these signals are most often N -acyl-L-homoserine lactones (AHL).…”

Section: Introductionmentioning

confidence: 99%

RsaM: a transcriptional regulator of Burkholderia spp. with novel fold

et al. 2014

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Burkholderia cepacia complex (Bcc) is a set of closely related bacterial species that are notorious pathogens of cystic fibrosis patients, responsible for life-threatening lung infections. Expression of several virulence factors of Bcc is controlled by a mechanism known as quorum sensing (QS). QS is a means of bacterial communication used to coordinate gene expression in a cell-density–dependent manner. The system involves the production of diffusible signaling molecules (N-acyl-L-homoserine lactones, AHLs), that bind to cognate transcriptional regulators and influence their ability to regulate gene expression. One such system that is highly conserved in Bcc consists of CepI and CepR. CepI is AHL synthase, while CepR is an AHL-dependent transcription factor. In most members of the Bcc group, the cepI and cepR genes are divergently transcribed and separated by additional genes. One of them, bcam1869, encodes the BcRsaM protein, which was recently postulated to modulate the abundance or activity of CepI or CepR. Here we show the crystal structure of BcRsaM from B. cenocepacia J2315. It is a single-domain protein with unique topology and presents a novel fold. The protein is a dimer in the crystal and in solution. This regulator has no known DNA binding motifs and direct binding of BcRsaM to the cepI promoter could not be detected in in vitro assays. Therefore, we propose that the modulatory action of RsaM might result from interactions with other components of the QS machinery rather than from direct association with the DNA promoter.

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“…Este transposón se caracteriza por transportar los genes erm(B) y mef(E) debido a la adquisición del gen erm(B) en aislamientos del clon Taiwán 19F -ST236. Se ha planteado la hipótesis de que el CC271 ha emergido como un grupo 'clonal' exitoso a partir un linaje del clon Taiwán 19F -ST236 que contiene el Tn2010 y presentó reemplazo del tipo capsular como respuesta a la presión selectiva de la vacuna conjugada heptavalente (31)(32)(33). El Tn2010 ha sido reportado en Estados Unidos (33), China (32,34) y Venezuela (30).…”

Section: Discussionunclassified