Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19F NMR

Fedorenko, Michael; Alesio, Jessica; Fedorenko, Anatoliy; Slitt, Angela L.; Bothun, Geoffrey D.

doi:10.1016/j.chemosphere.2020.128083

Cited by 39 publications

(32 citation statements)

References 66 publications

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“…For instance, the PFAS-to-lipid associations are explained in animal studies by transactivation of peroxisome proliferator-activated receptor α (PPARα) contributing to a liver metabolic pathway which plays an important role in the regulation of cholesterol and triglyceride levels; or oxidative stress has been proposed to be a key player in the pathogenesis of hypertension [44][45][46][47]. Other putative molecular initiating/key events for PFAS might be explained by mitochondrial dysfunction, interference of protein binding, partitioning into lipid bilayers (enterohepatic cycling of both bile acids and PFAS), altered calcium homeostasis, and inappropriate activation of molecular signals controlling cell functions [14,48]. As for CVD, few studies of occupationally exposed workers and nonoccupationally exposed population have reported associations between PFAS exposure and CVD [49].…”

Section: Discussionmentioning

confidence: 99%

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Jeddi

Zuanna

Barbieri

et al. 2021

IJERPH

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Background: Studies on the association between perfluoroalkyl substances (PFAS) and metabolic syndrome (MetS) are limited, and results are inconsistent. We aimed to examine the associations between PFAS serum levels and the prevalence of MetS among highly exposed young adults (ages 20–39) residents of a large area of the Veneto Region (North-Eastern Italy) primarily stemming from PFAS water contamination before September 2013. A total of 15,876 eligible young adult residents living in the investigated municipalities were enrolled in the study from January 2017 to July 2019. Methods: MetS was defined by using a modified harmonized definition requiring the presence of 3 of the following: obesity (body mass index ≥30), elevated triglyceride (TG), reduced high-density lipoprotein cholesterol, elevated blood pressure, and hemoglobin A1c ≥ 6.1% or self-reported diabetes mellitus or drug treatment for hyperglycemia. Multivariable generalized additive models were performed to identify the associations between four serum PFAS, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), and risk of MetS controlling for potential confounders. Results: A total of 1282 participants (8.1%) met the criteria of MetS with a higher prevalence among men. PFOA, PFHxS, and PFNA were not associated with the risk of MetS, whereas PFOS showed a consistent protective effect against the risk of MetS (OR 0.76, (95% CI: 0.69, 0.85) per ln-PFOS). However, we found statistically significant positive associations between PFAS serum levels and individual components of MetS, mainly elevated blood pressure and elevated TG. Conclusion: Our results did not support a consistent association between PFAS and MetS and conflicting findings were observed for individual components of MetS.

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Section: Discussionmentioning

confidence: 99%

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Jeddi

Zuanna

Barbieri

et al. 2021

IJERPH

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“…The surface chemistry of microplastics governs their interaction with external interfaces and could drive the adsorption of contaminants on its large surface area. This is a topic of concern due to the increasing presence of persistent organic pollutants (POPs) such as perfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs) in aquatic environments. , Reports have shown that such compounds are found on microparticles at concentrations several orders of magnitude higher than those in surrounding environments. , The specific mechanisms of adsorption are still to be investigated with respect to the various environmental parameters involved, such as temperature, pH, and salinity. There is growing evidence indicating that microplastics are ingested by marine organisms, and the implications regarding exposure to organic pollutants are being debated .…”

Section: Wettability and Adsorptionmentioning

confidence: 99%

Microplastics through the Lens of Colloid Science

Harraq

Bharti

2021

ACS Environ. Au

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Microplastics are sub-millimeter-sized fragments of plastics and a relatively new class of pollutant increasingly found in the environment. Due to their size and surface area to volume ratio, the physicochemical characteristics of microplastics can diverge from those of their macroscopic counterparts. This is partly why it is challenging to understand their origin, analyze their behavior, and predict their fates in the environment compared to large pollutants. We believe that adopting a view of microplastics as a colloid provides a holistic framework that connects their physical properties and surface chemistries with observations of their dynamics in the environment. In particular, we discuss the role of fundamental principles of colloid science in interpreting phenomena of wetting, adsorption, aggregation, and transport of microplastics. Colloid and interface science can provide the tools to couple or decouple the physicochemical behaviors of microplastics, which may aid in understanding the environmental challenge both from a fundamental perspective and with respect to practical remediation methods.

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“…Although solubilities can be measured directly, much less is known about how PFAS compounds such as PFOA and PFOS might move out of an aqueous environment and into bacterial cells. There is evidence that these compounds can partition into cellular membranes passively (Fitzgerald et al, 2018b); in one case, this was shown to affect the quorum sensing response (Fitzgerald Fluorinated molecules, even perfluorinated, can bind to non-catalytic proteins such as bovine serum albumin (Fedorenko et al, 2021). This indicates that natural proteins and their amino acid side chains have the potential for evolving pre-equilibrium binding of these molecules as substrates.…”

Section: Fluorine Chemistry Is Different From Other Halogens Fluorine...mentioning

confidence: 99%

“…Fluorinated molecules, even perfluorinated, can bind to non‐catalytic proteins such as bovine serum albumin (Fedorenko et al ., 2021 ). This indicates that natural proteins and their amino acid side chains have the potential for evolving pre‐equilibrium binding of these molecules as substrates.…”

Section: Fluorine Chemistry Is Different From Other Halogens Fluorine...mentioning

confidence: 99%

Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances

Wackett

2021

Microbial Biotechnology

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Poly-and perfluorinated chemicals, including perfluorinated alkyl substances (PFAS), are pervasive in today's society, with a negative impact on human and ecosystem health continually emerging. These chemicals are now subject to strict government regulations, leading to costly environmental remediation efforts. Commercial polyfluorinated compounds have been called 'forever chemicals' due to their strong resistance to biological and chemical degradation. Environmental cleanup by bioremediation is not considered practical currently. Implementation of bioremediation will require uncovering and understanding the rare microbial successes in degrading these compounds. This review discusses the underlying reasons why microbial degradation of heavily fluorinated compounds is rare. Fluorinated and chlorinated compounds are very different with respect to chemistry and microbial physiology. Moreover, the end product of biodegradation, fluoride, is much more toxic than chloride. It is imperative to understand these limitations, and elucidate physiological mechanisms of defluorination, in order to better discover, study, and engineer bacteria that can efficiently degrade polyfluorinated compounds.

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Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19F NMR

Cited by 39 publications

References 66 publications

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Microplastics through the Lens of Colloid Science

Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances

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