Dominant Inheritance in Familial Generalised Articular Hypermobility

Abstract

Two individuals with generalised articular hypermobility are described. There are many affected members in both kindreds, and the pedigrees indicate that the disorder is transmitted as an autosomal dominant trait. Orthopaedic complications and deformities are common in one family but absent in the other. It is suggested therefore that the two disorders are distinct and separate genetic entities.

Joint hypermobility leading to osteoarthrosis and chondrocalcinosis.

“…There is also some evidence of a distinct autosomal dominant inheritance (Beighton and Horan, 1970) though these patients may be spared premature osteoarthrosis. Ethnic differences have been noted (Schweitzer, 1970) and hypermobility also varies with age, sex, and athletic training.…”

Begleiterkrankungen bei prim�rer Gelenkhypermobilit�t

“…Die Untersuchung von beschwerdefreien, suspekten Familienmitgliedern kann, bei autosomal-dominantem Erbgang mit großer Penetranz, in gleicher Weise empfohlen werden [10,36,56,60]. Harmlos erscheinende "Spinnenfinger", ein asthenischer Habitus und andere Symptome am Bewegungsapparat können hierbei als Wegweiser für lebensrettende Untersuchungsschritte dienen.…”

Avaliação da flexibilidade: valores normativos do flexiteste dos 5 aos 91 anos de idade

“…Flexibility, one of the main health-related and performance-related variables of physical fitness, is defined by Araújo 4 as the maximum physiological passive range of motion of a given joint movement. Body flexibility varies with age, gender and a regular pattern of physical exercises [5][6][7][8][9][10][11][12] . Flexibility is not uniform in the different joints and body movements, and it is common that, in a given individual, their maximal range of motion is good for certain movements and limited for others, thus representing maps were later redesigned 18 and a series of studies were conducted [19][20][21] , culminating in a doctoral thesis 22 in which a preliminary database with approximately 500 cases was presented.…”