“…Causes of peripheral retinal neovascularization can be divided into several categories: 1) congenital, such as Coats' disease, which these girls clearly did not have; 2) vascular occlusive syndromes, such as diabetes mellitus, branch vein occlusion, retinopathy of prematurity, and hyperviscosity syndromes, of which again there was no evidence in this family; 3) inflammatory, such as sarcoidosis and peripheral uveitis; and 4) hereditary. Among the hereditary category would be familial exudative vitreoretinopathy (9), incontinentia pigmenti (10), and a dominantly inherited form of peripheral retinal neovascularization (11). None of these conditions, however, is compatible with the systemic findings of our patients, Hypothyroidism in association with SED has not been described previously.…”