Domino Addition/Annulation of δ‐Alkynylaldehydes and Oxygen Nucleophiles: A New Entry to [1,4]Oxazino[4,3‐a]indoles.

Abstract

Oxazine derivatives R 0595Domino Addition/Annulation of δ-Alkynylaldehydes and Oxygen Nucleophiles: A New Entry to [1,4]Oxazino[4,3-a]indoles. -An unusual nucleophilic addition of alkoxide nucleophiles to a triple bond of δ-acetylenic aldehydes (I) results in annulation reaction to give the title compounds in good yields. -(ABBIATI*, G.; CANEVARI, V.; CAIMI, S.; ROSSI, E.; Tetrahedron Lett. 46 (2005) 42, 7117-7120; Ist. Chim. Org., Fac. Farm., Univ. Stud. Milano, I-20133 Milano, Italy; Eng.) -Mais 05-163