DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety

Linden, M.M.D. van der; Ratingen, A.R. van; Rappard, Dominique C. van; Nieuwenburg, S; Spuls, Phyllis I.

doi:10.1111/bjd.15155

Cited by 58 publications

(54 citation statements)

References 45 publications

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“…A noninferiority study of minocycline 100 mg with doxycycline 40 mg MR was assessed as being at unclear risk of bias . Patients’ assessments showed that 22 of 40 participants with minocycline achieved excellent or good improvement vs. 20 of 40 in the doxycycline 40 mg MR group (RR 1·10, 95% CI 0·72–1·67; low‐certainty evidence).…”

Section: Resultsmentioning

confidence: 99%

Interventions for rosacea based on the phenotype approach: an updated systematic review includingGRADEassessments

et al. 2019

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SummaryBackgroundRosacea is a common chronic facial dermatosis. Classification of rosacea has evolved from subtyping to phenotyping.ObjectivesTo update our systematic review on interventions for rosacea.MethodsWe searched CENTRAL, MEDLINE, Embase, LILACS, Science Citation Index and ongoing trials registers (March 2018) for randomized controlled trials. Study selection, data extraction, risk‐of‐bias assessment and analyses were carried out independently by two authors. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to assess certainty of evidence.ResultsWe included 152 studies (46 were new), comprising 20 944 participants. Topical interventions included brimonidine, oxymetazoline, metronidazole, azelaic acid, ivermectin and other topical treatments. Systemic interventions included oral antibiotics, combinations with topical treatments or other systemic treatments. Several studies evaluated laser or light‐based treatment. We present the most current evidence for rosacea management based on a phenotype‐led approach.ConclusionsFor reducing temporarily persistent erythema there was high‐certainty evidence for topical brimonidine and moderate certainty for topical oxymetazoline; for erythema and mainly telangiectasia there was low‐to‐moderate‐certainty evidence for laser and intense pulsed light therapy. For reducing papules/pustules there was high‐certainty evidence for topical azelaic acid and topical ivermectin; moderate‐to‐high‐certainty evidence for doxycycline 40 mg modified release (MR) and isotretinoin; and moderate‐certainty evidence for topical metronidazole, and topical minocycline and oral minocycline being equally effective as doxycycline 40 mg MR. There was low‐certainty evidence for tetracycline and low‐dose minocycline. For ocular rosacea, there was moderate‐certainty evidence that oral omega‐3 fatty acids were effective and low‐certainty evidence for ciclosporin ophthalmic emulsion and doxycycline.

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Section: Resultsmentioning

confidence: 99%

Interventions for rosacea based on the phenotype approach: an updated systematic review includingGRADEassessments

et al. 2019

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“…In this issue of the BJD, van der Linden et al 4 report the findings of a randomized, non-inferiority trial comparing doxycycline 40 mg with minocycline 100 mg daily for papulopustular rosacea. Primary outcomes include overall lesion counts and patient's scores on a Rosacea-specific version of the Health-related Quality of Life questionnaire (RosaQoL).…”

mentioning

confidence: 99%

Current perspective on actinic keratosis: a review

2016

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Actinic keratoses (AKs) are common, with prevalence in the U.S.A. estimated at almost 40 million in 2004 and annual costs of > $1 billion (U.S.D.). However, there is no universally accepted definition of AK and thus it is difficult to identify reliably. AKs are lesions of epidermal keratinocytic dysplasia that result from chronic sun exposure and have the ability to progress to invasive squamous cell carcinoma (SCC), but clinicians disagree about whether AKs are premalignant lesions, superficial SCCin situ or epiphenomena of chronically sun-damaged skin. Yearly AK to SCC progression rates of 0·6% were reported in an elderly population with multiple prior keratinocyte carcinomas (KCs); and rates of spontaneous AK regression have been reported to be > 50%, but regressed lesions often reappear. As AKs have both cosmetic consequences and potential for malignant transformation, there are multiple reasons for treatment. There is no current agreement on the most efficacious treatment, but 5-fluorouracil has been shown to both prevent and treat AKs, and imiquimod and photodynamic therapy may have the best cosmetic outcomes. AKs may be treated to improve appearance and relieve symptoms, but the keratinocytic dysplasia that gives rise to malignancy, and sometimes appears as an AK, may be what actually threatens patient health. Thus, treatments should aim to decrease the risk of KC or facilitate KC diagnosis by reducing the potential for misidentification created when a KC appears in a field of AKs. Improved agreement among clinicians on AK definition may improve management.

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“…In ophthalmology, doxycycline is usually administered in patients affected by ocular rosacea and posterior blepharitis (18) . The doxycycline recommended dose is 40 mg modi ed release once daily, which could be replaced by minocycline 100 mg, based on patient tolerance or particular requirements (19) .…”

Section: Insights Into the Doxycycline Activitymentioning

confidence: 99%

“…The rationale in its administration is proteolysis inhibition promoted by matrix metalloproteinases (MMPs) (18,20) . MMPs are involved in the regulation of chemical and biological process likes vascular remodeling and angiogenesis (21) , so doxycycline also has anti-angiogenic properties (22) .…”

Section: Insights Into the Doxycycline Activitymentioning

confidence: 99%

Role of doxycycline, oral steroids, and nasal steroid in treatment of anosmia due to COVID-19 with the new insights into the doxycycline activity.

Husain

Ahmed

Husain

2020

Preprint

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Background All over the world, severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) has been the most important public health issue this year; recently this was re-named as corona virus disease 2019 (COVID-19) by the World Health Organization (WHO). Olfactory or gustatory dysfunction is often reported as a symptom.Aims Aim of the study is to evaluate the role and effectiveness of Doxycycline, Oral Methyl Prednisolone, and Topical Nasal Steroid (Mometasone) in the treatment of COVID-19 related anosmia/hyposmiaMaterial and Methods Total 64 patients were evaluated randomly who were COVID-19 positive and developed recent onset of anosmia/hyposmia. They were divided into two groups 32 each. First group was treated with Doxycycline, Oral Methyl Prednisolone, and Topical Nasal Steroid (Mometasone). Second group was the control group and was given placebo and Olfactory training.Results Out of 32 patients 27 patients completely recover after only 2 days of the administration of above treatment. Out of the remaining 5 patients 4 had partial resolution of the anosmia after 2 days and near complete resolution after 5-7 days, and 1 patient did not responded at all with the above treatment. Out of the control group 19 patient had near complete recovery after 7 days and rest 13 patient did not recover after 10 days.Conclusion The above study showed a very promising results but many more similar studies are needed following the similar treatment protocol on a larger group of patients suffering from olfactory dysfunction.

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DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety

Cited by 58 publications

References 45 publications

Interventions for rosacea based on the phenotype approach: an updated systematic review includingGRADEassessments

Interventions for rosacea based on the phenotype approach: an updated systematic review includingGRADEassessments

Current perspective on actinic keratosis: a review

Role of doxycycline, oral steroids, and nasal steroid in treatment of anosmia due to COVID-19 with the new insights into the doxycycline activity.

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