DOMOIC ACID PRODUCTION IN <i>NITZSCHIA</i> SP. (BACILLARIOPHYCEAE) ISOLATED FROM A SHRIMP‐CULTURE POND IN DO SON, VIETNAM

Kotaki, Yuichi; Koike, Kazuo; Yoshida, Makoto; Thuộc, Chu Văn; Huyen, Nguyen Thi Minh; Hoi, Nguyen Chu; Fukuyo, Yasuwo; Kodama, Masaaki

doi:10.1046/j.1529-8817.2000.99209.x

Cited by 84 publications

(67 citation statements)

References 20 publications

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“…However, analytical sensitivity of the ELISA method used here is considerably better than previous methods, and DA production was detected, albeit in much lower quantities than either P. multiseries and P. australis. Based on our finding, and on the fact that at least one species of the related Nitzschia genus also produces DA (Kotaki et al 2000), we believe it is reasonable to anticipate that all Pseudo-nitzschia species produce DA to some degree, though not all will produce enough to generate toxicity at higher trophic levels under all conditions.…”

Section: Discussionmentioning

confidence: 99%

Domoic acid: The synergy of iron, copper, and the toxicity of diatoms

et al. 2005

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Diatom blooms generated by the alleviation of iron limitation in high nitrate-low chlorophyll (HNLC) regions of the oceans often are composed of pennate diatoms of the genus Pseudo-nitzschia, many of which periodically produce the potent neurotoxin domoic acid. We show that toxigenic diatoms have an inducible high-affinity iron uptake capability that enables them to grow efficiently on iron complexed by strong organic ligands in seawater. This low-iron adaptive strategy requires copper and domoic acid, a copper chelator whose production increases sharply when both iron and copper are limiting. Addition of either domoic acid or copper to seawater improves the growth of Pseudo-nitzschia spp. on strongly complexed iron during deck incubation experiments with natural phytoplankton. Our findings indicate that domoic acid is a functional component of the unusual high-affinity iron acquisition system of these organisms. This system may help explain why Pseudo-nitzschia spp. are persistent seed populations in oceanic HNLC regions, as well as in some neritic regions. Our findings also indicate that in the absence of an adequate copper supply, iron-limited natural populations of Pseudo-nitzschia will become increasingly toxic.

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Section: Discussionmentioning

confidence: 99%

Domoic acid: The synergy of iron, copper, and the toxicity of diatoms

et al. 2005

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“…Bates et al 1989, Maranda et al 1990, Lundholm et al 1994, Kotaki et al 2000. During blooms of toxinproducing diatoms, domoic acid may accumulate in the food web and an array of different organisms such as shellfish may serve as vectors for the toxin (e.g.…”

Section: Introductionmentioning

confidence: 99%

Lack of allelopathic effects of the domoic acid-producing marine diatom Pseudo-nitzschia multiseries

Lundholm¹,

Hansen²,

Kotaki³

2005

Mar. Ecol. Prog. Ser.

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Many Pseudo-nitzschia species produce the toxin domoic acid, which accumulates in the food web during blooms, sometimes causing amnesic shellfish poisoning (ASP) in higher trophic levels, including humans. In addition, Pseudo-nitzschia species have been reported to form longlasting monospecific blooms, and a possible explanation for this could be allelopathic effects of the toxin, since domoic acid has been detected in high amounts in the surrounding medium in stationary growth phase. We therefore examined the potential allelopathic effects of P. multiseries and its toxin domoic acid. In mixed-batch culture studies of domoic acid-producing P. multiseries and the algal test species Chrysochromulina ericina, Heterocapsa triquetra, Eutreptiella gymnastica and Rhodomonas marina, no allelopathic effects of P. multiseries were found. Different growth results using 2 different strains of P. multiseries grown with C. ericina were explained by minor differences in pH. Bioassays testing the effect of domoic acid itself on 9 different phytoplankton species, namely C. ericina, E. gymnastica, Karenia mikimotoi, H. triquetra, Heterosigma akashiwo, Prorocentrum minimum, P. micans, Pyramimonas propulsa and R. marina confirmed a lack of allelopathic effects of the toxin. This lack of allelopathic effect of the shellfish-poisoning toxin domoic acid seems to correspond with the results of phytoplankton species causing DSP (diarrheic shellfish poisoning) and PSP (paralytic shellfish poisoning), where it appears that these shellfish-poisoning toxins do not cause allelopathic effects either.

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“…The production of DA has been reported also for one strain of a pennate diatom, Amphora coffeaeformis (Shimizu et al 1989) and from Nitzschia navis-varingica isolated from a shrimp culture pond in Vietnam (Kotaki et al 2000, Lundholm & Moestrup 2000.…”

Section: Introductionmentioning

confidence: 99%

Bacterial involvement in determining domoic acid levels in Pseudo-nitzschia multiseries cultures

Stewart¹

2008

Aquat. Microb. Ecol.

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DOMOIC ACID PRODUCTION IN NITZSCHIA SP. (BACILLARIOPHYCEAE) ISOLATED FROM A SHRIMP‐CULTURE POND IN DO SON, VIETNAM

Cited by 84 publications

References 20 publications

Domoic acid: The synergy of iron, copper, and the toxicity of diatoms

Domoic acid: The synergy of iron, copper, and the toxicity of diatoms

Lack of allelopathic effects of the domoic acid-producing marine diatom Pseudo-nitzschia multiseries

Bacterial involvement in determining domoic acid levels in Pseudo-nitzschia multiseries cultures

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