Domperidone: Review of Pharmacology and Clinical Applications in Gastroenterology

Abstract

Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier. It thus provides an excellent safety profile for long-term administration orally in the recommended doses. Domperidone is widely used in many countries and can now be officially prescribed to patients in the United States by an investigational new drug application for the treatment of gastroparesis and any condition causing chronic nausea and vomiting. In view of this additional clinical exposure of domperidone to a new generation of gastroenterologists and other specialists, the purpose of this timely review is to revisit the pharmacology, clinical application, and safety profile of this beneficial medication.

Diabetic gastroparesis: epidemiology, mechanisms of development, modern approaches to the management

“…лечение этим препаратом не покрывается страховкой, поэтому за рубежом пациентам приходится дополнительно платить за него от 50 до 100 долларов СШа в месяц. домперидон, как и метоклопрамид, блокируют дофаминовые рецепторы 2 типа в хеморецепторной триггерной зоне и дополнительно к периферическому прокинетическому действию, также имеет и противорвотный эффект [43,46]. в последнее время все чаще применяются более современные и безопасные прокинетики, такие как итоприд и прукалоприд [6,9].…”

Matrix Tablet Containing Quaternary Inclusion Complex of Domperidone for Treatment of Diabetic Gastroparesis

“…b 1 , b 2 , b 3 , b 4 and b 5 are the regression coefficients. X 1 and X 2 stand for the main effects; X 1 X 2 are the interaction terms, which show how response changes when two factors are changed simultaneously.…”

“…4,5 It has also been used for the treatment of migraine, 6,7 gastroparesis 8 and functional dyspepsia. 9 As it poorly penetrates the blood-brain barrier, it shows few Submission Date: 11-04-2017; Revision Date: 13-07-2017; Accepted Date: 27-09-2017 neurological side-effects.…”

Association between polymorphism of dopamine D2 receptor genes and therapeutic effect of domperidone in functional dyspepsia

“…However, the efficacy of these agents for FD varies among patients (7). Other medications such as anti-acids, anti-anxiety agents, or drugs for gastric mucosa protection and Helicobacter pylori eradication were also reported to be ineffective for all FD patients (8).…”