Donepezil in the treatment of ischemic stroke: Review and future perspective

Barfejani, Arnavaz Hajizadeh; Jafarvand, Mahbod; Seyedsaadat, Seyed Mohammad; Rasekhi, Roozbeh Tarighati

doi:10.1016/j.lfs.2020.118575

Cited by 25 publications

(11 citation statements)

References 55 publications

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“… 24 The present study investigated that treatment with neuroprotective drugs is beneficial to the early recovery of peripheral nerve function in the ischemic cortical after stroke. 5 , 6 , 12 CH-I is a bioactive substance isolated and purified from fresh pig brain tissue. 7 The free amino acids of 50–80% can enter brain neurons through the blood brain barrier (BBB) and strengthen protein synthesis in the brain.…”

Section: Discussionmentioning

confidence: 99%

“…2 A series of studies have shown that the application of neuroprotective drugs as adjuvant therapy of thrombolytic therapy can contribute to improving the neurological function of patients with ischemic stroke. [4][5][6] Cerebroprotein hydrolysate-I (CH-I), a mixture, was prepared from denatured proteins with a total nitrogen content of more than 120 mg/g. 7 It contained 16 kinds of amino acids and 25-35% small molecule polypeptides (<10,000 Da).…”

Section: Introductionmentioning

confidence: 99%

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The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats

Ren¹,

Ma²,

Wang³

et al. 2021

NDT

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Objective: To investigate the neuroprotective effect and mechanism of cerebroprotein hydrolysate-I (CH-I) on cerebral ischemia/reperfusion injury in rats. Methods: A total of 100 adult healthy male SD rats were randomly divided into a sham group, model group, CH-I treated group, and cerebrolysin (CBL) positive group, consisting of 20 rats in each group. The middle cerebral artery occlusion/reperfusion (MCAO/R) model of rats was built by inserting a suture into the left external carotid artery (ECA) through the internal carotid artery (ICA). Treatment was performed by intraperitoneal injection of CH-I (20 mg/kg). The neurobehavioral function of rats was evaluated by modified neurological severity scores (mNSS). TTC staining was used to detect the cerebral infarction volume (CIV) of rats. The morphological and structural changes of nerve cells were observed by HE staining and the neuronal apoptosis was counted by TUNEL assay. Immunohistochemical (IHC) analysis was used to detect BDNF and pMEK1/2 expressions. The expressions of BDNF, pMEK1/2, pERK1/2, and pCREB were determined with Western blotting. Results: After treatment with CH-I, the mNSS and CIV of rats were improved (P<0.05). And the CH-I can reduce the degeneration and apoptosis of nerve cells in rats (P<0.01). Western blotting showed that the expressions of pMEK1/2, pERK1/2, and pCREB in rats were increased, while the expression of BDNF was decreased after modeling (P<0.05). After treatment, the expressions of pMEK1/2, pERK1/2, and pCREB in the CH-I group were decreased (P<0.05), while the expression of BDNF was significantly increased (P<0.05) compared with the model group. IHC showed that the expression of BDNF and pMEK1/2 was consistent with Western blotting. Conclusion:It is suggested that the CH-I might play a neuroprotective role by inhibiting the expression of MEK-ERK-CREB and enhancing the expression of BDNF after cerebral ischemia/reperfusion injury, thus improving the neurobehavioral function of MCAO/R rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats

Ren¹,

Ma²,

Wang³

et al. 2021

NDT

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“…1999; Doyle et al. 2015; Berchtold et al 2020). Importantly, BBB function might also be influenced by signaling over α7nAChR (Dash et al.…”

Section: Brain Disorders With Affected Cholinergic Signalingmentioning

confidence: 99%

“…Use of cholinesterase inhibitors for treatment of cognitive impairment has also been postulated as a promising option in ischemic stroke, but the results of clinical studies are limited (Barfejani et al. 2020). A recent meta‐analysis showed that treatment with cholinesterase inhibitors may improve cognitive functions in patients after stroke and vascular dementia (Kim et al.…”

Section: Brain Disorders With Affected Cholinergic Signalingmentioning

confidence: 99%

Regulators of cholinergic signaling in disorders of the central nervous system

Winek

Soreq

Meisel

2021

Journal of Neurochemistry

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Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is currently the main treatment option to alleviate symptoms of Alzheimer's disease and has been postulated as a therapeutic strategy in acute brain damage (stroke and traumatic brain injury). However, the benefits of this treatment are still not clear. Importantly, cholinergic receptors are expressed both by neurons and by astrocytes and microglia, and binding of acetylcholine to the α7 nicotinic receptor in glial cells results in anti‐inflammatory response. Similarly, the brain fine‐tunes the peripheral immune response over the cholinergic anti‐inflammatory axis. All of these processes are of importance for the outcome of acute and chronic neurological disease. Here, we summarize the main findings about the role of cholinergic signaling in brain disorders and provide insights into the complexity of molecular regulators of cholinergic responses, such as microRNAs and transfer RNA fragments, both of which may fine‐tune the orchestra of cholinergic mRNAs. The available data suggest that these small noncoding RNA regulators may include promising biomarkers for predicting disease course and assessing treatment responses and might also serve as drug targets to attenuate signaling cascades during overwhelming inflammation and to ameliorate regenerative capacities of neuroinflammation.

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“…Compared with traditional diagnosis methods, automatic segmentation algorithms are characterized by high accuracy, high efficiency, objective analysis of lesions, strong repeatability, and scalability. Because of the complexity of brain diseases, clinicians often adopt multimodal MRI that can comprehensively reflect disease information [4], which was the focus of the study.…”

Section: Introductionmentioning

confidence: 99%

Identification and Diagnosis of Cerebral Stroke through Deep Convolutional Neural Network-Based Multimodal MRI Images

Pan

Zhang

Yang

et al. 2021

Contrast Media & Molecular Imaging

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This study aimed to explore the application value of multimodal magnetic resonance imaging (MRI) images based on the deep convolutional neural network (Conv.Net) in the diagnosis of strokes. Specifically, four automatic segmentation algorithms were proposed to segment multimodal MRI images of stroke patients. The segmentation effects were evaluated factoring into DICE, accuracy, sensitivity, and segmentation distance coefficient. It was found that although two-dimensional (2D) full convolutional neural network-based segmentation algorithm can locate and segment the lesion, its accuracy was low; the three-dimensional one exhibited higher accuracy, with various objective indicators improved, and the segmentation accuracy of the training set and the test set was 0.93 and 0.79, respectively, meeting the needs of automatic diagnosis. The asymmetric 3D residual U-Net network had good convergence and high segmentation accuracy, and the 3D deep residual network proposed on its basis had good segmentation coefficients, which can not only ensure segmentation accuracy but also avoid network degradation problems. In conclusion, the Conv.Net model can accurately segment the foci of patients with ischemic stroke and is suggested in clinic.

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Donepezil in the treatment of ischemic stroke: Review and future perspective

Cited by 25 publications

References 55 publications

The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats

The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats

Regulators of cholinergic signaling in disorders of the central nervous system

Identification and Diagnosis of Cerebral Stroke through Deep Convolutional Neural Network-Based Multimodal MRI Images

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