Donnan Equilibrium of Ionic Drugs in pH-Dependent Fixed Charge Membranes: Theoretical Modeling

Ramı́rez, Patricio; Alcaraz, Antonio; Mafé, Salvador; Pellicer, J.

doi:10.1006/jcis.2002.8508

Cited by 25 publications

(9 citation statements)

References 25 publications

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“…Note that these anthocyanin anions (for cation-exchange resin) and cations (for anion-exchange resin) in the solution at the surface of an ion-exchange material can decrease the adsorption capacity of a resin if they are not quickly and consistently removed to the solution volume, for example, by mixing. Similar to anthocyanins, phenols, amino acids, carboxylic acids, polybasic organic acids, and other ampholytic substances that are components of juices and wines [ 1 ] participate in protonation/deprotonation reactions with water, also affecting the pH of the internal solution of ion-exchange materials [ 93 , 94 , 95 , 96 ]. This particular effect is one of the reasons not previously discussed that produces differences in anthocyanin adsorption between single solutions and mixtures, for example, with amino acids [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Adsorption of Anthocyanins by Cation and Anion Exchange Resins with Aromatic and Aliphatic Polymer Matrices

Pismenskaya

Сарапулова

Klevtsova

et al. 2020

IJMS

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This study examines the mechanisms of adsorption of anthocyanins from model aqueous solutions at pH values of 3, 6, and 9 by ion-exchange resins making the main component of heterogeneous ion-exchange membranes. This is the first report demonstrating that the pH of the internal solution of a KU-2-8 aromatic cation-exchange resin is 2-3 units lower than the pH of the external bathing anthocyanin-containing solution, and the pH of the internal solution of some anion-exchange resins with an aromatic (AV-17-8, AV-17-2P) or aliphatic (EDE-10P) matrix is 2–4 units higher than the pH of the external solution. This pH shift is caused by the Donnan exclusion of hydroxyl ions (in the KU-2-8 resin) or protons (in the AV-17-8, AV-17-2P, and EDE-10P resins). The most significant pH shift is observed for the EDE-10P resin, which has the highest ion-exchange capacity causing the highest Donnan exclusion. Due to the pH shift, the electric charge of anthocyanin inside an ion-exchange resin differs from its charge in the external solution. At pH 6, the external solution contains uncharged anthocyanin molecules. However, in the AV-17-8 and AV-17-2P resins, the anthocyanins are present as singly charged anions, while in the EDE-10P resin, they are in the form of doubly charged anions. Due to the electrostatic interactions of these anions with the positively charged fixed groups of anion-exchange resins, the adsorption capacities of AV-17-8, AV-17-2P, and EDE-10P were higher than expected. It was established that the electrostatic interactions of anthocyanins with the charged fixed groups increase the adsorption capacity of the aromatic resin by a factor of 1.8–2.5 compared to the adsorption caused by the π–π (stacking) interactions. These results provide new insights into the fouling mechanism of ion-exchange materials by polyphenols; they can help develop strategies for membrane cleaning and for extracting anthocyanins from juices and wine using ion-exchange resins and membranes.

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Section: Resultsmentioning

confidence: 99%

Adsorption of Anthocyanins by Cation and Anion Exchange Resins with Aromatic and Aliphatic Polymer Matrices

Pismenskaya

Сарапулова

Klevtsova

et al. 2020

IJMS

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“…Transport phenomena in many biophysical systems and biotechnological applications involve the permeation of ionic species through fixed charge membranes. [1][2][3][4][5][6][7][8][9][10] Because the local pH and electrolyte concentration of the membrane solution regulates the ionization state of the membrane fixed charges 5,7 and the permeate ion, 4,8 the transport rates can be adjusted by the external solutions. It has been shown [5][6][7] that the permeability to an ionic drug of a fixed charge membrane changes by several orders of magnitude when the external pH is varied.…”

Section: Introductionmentioning

confidence: 99%

Modeling of pH-Switchable Ion Transport and Selectivity in Nanopore Membranes with Fixed Charges

et al. 2003

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The pH-switchable ion transport and selectivity in nanopore membranes with fixed charges is theoretically analyzed using a model based on the Nernst−Planck flux equations. The ionization state of the weak polyelectrolyte groups attached to the pore surface appears to be a crucial factor in order to understand the conductive properties of the pore. The model allows for the calculation of the fluxes of all of the ionic species involved and the membrane potential. Comparison of the theoretical results with the experimental data by Martin el al. (Science 1995, 268, 700−2; J. Phys. Chem. B 2001, 105, 1925−34; and Adv. Mater. 2001, 13, 1351−62) and Stroeve et al. (Langmuir 2000, 16, 2401−4; and Langmuir 2001, 17, 5271−5) for surface modified nanopores with fixed charges shows that the model can describe qualitatively the changes of the permeate ion flux and the membrane potential with the pH and the solute concentration of the external solutions. The effect of applying an electric potential to the nanopore walls is also studied. Some of the main characteristics that allow a simple description of pH-switchable effects on nanopore membranes with fixed charges are clearly shown.

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“…The described phenomenon is the key for explaining the change in the IEM thickness, d, and their destruction during long-term (thousands of hours) operation in ED processing of the food industry liquid media. An increase in AEM thickness is observed, for example, in liquid media containing anions of polybasic carboxylic acids and/or phosphoric acid [171]. Moreover, in the case of a heterogeneous membrane MA-41, which contains a poly-styrene matrix regularly crosslinked with divinylbenzene, a new stable state of the matrix (characterized by the cessation of increase in d) is reached within ≈50 hours after replacing the NaCl solution with solutions of polybasic acid anions.…”

Section: Stretching Of the Polymer Ion Exchange Matrixmentioning

confidence: 99%

A Review on Ion-Exchange Membrane Fouling during the Electrodialysis Process in the Food Industry, Part 1: Types, Effects, Characterization Methods, Fouling Mechanisms and Interactions

et al. 2021

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Electrodialysis (ED) was first established for water desalination and is still highly recommended in this field for its high water recovery, long lifetime and acceptable electricity consumption. Today, thanks to technological progress in ED processes and the emergence of new ion-exchange membranes (IEMs), ED has been extended to many other applications in the food industry. This expansion of uses has also generated several problems such as IEMs’ lifetime limitation due to different ageing phenomena (because of organic and/or mineral compounds). The current commercial IEMs show excellent performance in ED processes; however, organic foulants such as proteins, surfactants, polyphenols or other natural organic matters can adhere on their surface (especially when using anion-exchange membranes: AEMs) forming a colloid layer or can infiltrate the membrane matrix, which leads to the increase in electrical resistance, resulting in higher energy consumption, lower water recovery, loss of membrane permselectivity and current efficiency as well as lifetime limitation. If these aspects are not sufficiently controlled and mastered, the use and the efficiency of ED processes will be limited since, it will no longer be competitive or profitable compared to other separation methods. In this work we reviewed a significant amount of recent scientific publications, research and reviews studying the phenomena of IEM fouling during the ED process in food industry with a special focus on the last decade. We first classified the different types of fouling according to the most commonly used classifications. Then, the fouling effects, the characterization methods and techniques as well as the different fouling mechanisms and interactions as well as their influence on IEM matrix and fixed groups were presented, analyzed, discussed and illustrated.

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Donnan Equilibrium of Ionic Drugs in pH-Dependent Fixed Charge Membranes: Theoretical Modeling

Cited by 25 publications

References 25 publications

Adsorption of Anthocyanins by Cation and Anion Exchange Resins with Aromatic and Aliphatic Polymer Matrices

Adsorption of Anthocyanins by Cation and Anion Exchange Resins with Aromatic and Aliphatic Polymer Matrices

Modeling of pH-Switchable Ion Transport and Selectivity in Nanopore Membranes with Fixed Charges

A Review on Ion-Exchange Membrane Fouling during the Electrodialysis Process in the Food Industry, Part 1: Types, Effects, Characterization Methods, Fouling Mechanisms and Interactions

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