Donor–acceptor Stenhouse adduct formation for the simple and rapid colorimetric detection of amphetamine-type stimulants

Visible light-responsive materials: the (photo)chemistry and applications of donor–acceptor Stenhouse adducts in polymer science

“…, amphetamines). Both small molecule furan adducts in solution or on filter paper substrates 162–164 and furan adducts immobilized in polymer matrices 117,151 were explored.…”

“…For example, the strong coloration as a result of DASA formation from the reaction of furan adducts and amines has been used as a colorimetric method to detect amines, including biogenic amines in food spoilage detection, amino acids, or drugs (e.g., amphetamines). Both small molecule furan adducts in solution or on filter paper substrates [162][163][164] and furan adducts immobilized in polymer matrices 117,151 were explored.…”

Interpol Review of Drug Analysis 2019-2022

“…2019 GC/MS method for fenethylline profiling of seized samples ; LC-QTOF-MS method for the simultaneous analysis of 111 amine-based compounds belonging to ergogenics, anorectics and other active components including phenethylamines (amphetamines, ephedrines), sibutramine or yohimbine [ 475 ]; excitation-emission matrix fluorescence combined with parallel factor analysis for quantitative analysis of the ATSs illegal drugs [ 476 ]; 2020 investigation of the efficiency and effectiveness of a gas-to-liquid (GTL) extraction system for the extraction of amphetamine-type substances and their precursors from the vapor phase [ 477 ]; LC-MS/MS method for detection of the presence of synthetic amines in dietary supplements [ 478 ]; enantioselective HPLC-MS/MS method for the quantification of (R)-AMP, (S)-AMP, (R)-MA, (S)-MA, (1R,2R)-pseudoephedrine, (1S,2S)-pseudoephedrine, (1R,2S)-ephedrine, (1S,2R)-ephedrine, (1R,2S)-norephedrine, (1S,2R)-norephedrine, (R)-cathinone, (S)-cathinone, and (1S,2S)-norpseudoephedrine (cathine) [ 479 ]; 2021 review of MA and AMP detection and roadside testing [ 480 ]; determination of the variations in delta C-13 and delta N-15 values of nitrogen sources used in the clandestine production of ATSs using isotope ratio mass spectrometry [ 481 ]; electrochemiluminescence strategy for the screening of MA and AMP [ 482 ]; review of laboratory-based and portable methods for detection of ATSs [ 483 ]; review of the prevalence of ATSs in Iran [ 484 ]; SALDI-MS method for the analysis of ATSs, including MA, MDMA, MDEA, and 4-fluoromethamphetamine (4-FMA) [ 485 ]; ATS drug classification using a one-dimensional convolutional neural network model [ 486 ]; 2022 colorimetric assay for detection of ATSs in aqueous solution, spiked drinks, and ‘ecstasy’ tablets [ 487 ]; development and validation of a GC-MS method for identification and quantification of AMP, MA, MDA and MDMA [ 488 ]; development of drug screening kits for the detection of ATSs in drinks [ 489 ]; analysis of feature selection method for 3D molecular structure of ATS drugs [ 490 ]; study of the pharmacological properties of MDA analogues and two related amphetamine-based compounds (N,alpha-DEPEA and DPIA) detected in street drug samples or in sport supplements [ 491 ]; chiral analysis of AMP (n = 143), MDMA (n = 94), and MA (n = 528) in samples seized in southern Germany in 2019 and 2020 using different chromatographic methods [ 492 ]; comparison of different chiral selectors for the enantiomeric determination of amphetamine-type substances by SPE-CE-MS/MS [ 493 ]; ultrahigh performance LC-MS/MS (UPLC-MS/MS) method coupled with magnetic SPE (MSPE) for determination of ultra-trace ATSs [ 494 ]; desk review of Vietnamese national drug policy documents regarding ATSs and in-depth key informant interviews were conducted from 2019 to 2021 [ 495 …”

Meldrum’s Acid Furfural Conjugate MAFC: A New Entry as Chromogenic Sensor for Specific Amine Identification

“…DFT calculations revealed three possible structures of which the neutral form and the anionic form formed via dissociation were the most probable ones. In another instance, a real-world application was presented by Cho et al in the field of forensic drug analysis [ 56 ]. On-site field tests for amphetamine-type stimulants like methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) in aqueous solutions, spiked drinks, or even tablets are highly necessary to be able to quickly grasp the danger of a situation.…”

“…( E ) Graphical depiction of MDMA and METH sensing possibility with MAFC in solution as well as solid phase. Reprinted with permission from [ 56 ].…”