Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool

Abstract

ace transplantation has become the standard of care for selected severely disfigured patients. 1 A successful facial vascularized composite allotransplant requires careful donorrecipient matching. 2 The process of identifying a suitable donor can be challenging and timeconsuming. One must consider invisible (e.g., immunologic, infectious) compatibility criteria to minimize the risk of acute (and chronic) allograft rejection and infection. [3][4][5] In addition, visible (physical appearance) compatibility criteria bear great relevance for facial vascularized composite allotransplant donor-recipient matching. 6 Some donor exclusion criteria such as sex, skin color,

Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study

“…3 The majority of potential fVCA donors are CMV seropositive (60%) and thus it is more likely that seronegative candidates are offered a CMV+ transplant. 4,5 In solid organ transplantation (SOT), CMV serostatus mismatch of donor and recipient (D+/R−) is the major risk factor for developing CMV disease and appears to impact longterm patient and graft outcomes. [5][6][7] In a cohort of hand transplant patients, a possible link between CMV infection and allograft rejection was suggested.…”