Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds: Implications for DNA–protein selectivity

A Potent Trans‐Diimine Platinum Anticancer Complex Photoactivated by Visible Light

“…The pyridines appear to remain strongly bound to platinum, even after photoactivation. Planar ligands in platinum(II) species have been shown to reduce the rate of DNA binding,15 and trans complexes offer the possibility of forming DNA–protein as well as DNA–DNA crosslinks 16 . Trans platinum(II) complexes themselves have attracted increasing attention since the discovery that complexes such as trans ‐[PtCl 2 {E‐HNC‐ (OCH 3 )CH 3 } 2 ] can exhibit higher cancer cell cytotoxicity than their cis isomers 17.…”

Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

“…This splitting effect may arise from hindered rotation about the Pt-N bond [56][57][58] Figure S16). Increasing the pH to 11 did not have an effect on the intensity of the signals.…”

A Potent Trans‐Diimine Platinum Anticancer Complex Photoactivated by Visible Light

“…Planar ligands in platinum(II) species have been shown to reduce the rate of DNA binding, [15] and trans complexes offer the possibility of forming DNA-protein as well as DNA-DNA crosslinks. [16] Trans platinum(II) complexes themselves have attracted increasing attention since the discovery that complexes such as trans-[PtCl 2 {E-HN=C-(OCH 3 )CH 3 } 2 ] can exhibit higher cancer cell cytotoxicity than their cis isomers. [17] Sterically hindered complexes, such as trans-[PtCl 2 -(4-picoline)(piperidine)] and trans-[PtCl 2 (4-picoline)(piperizine)]HCl, are cytotoxic towards cancer cells and are also distinct from cisplatin in their mechanism of action.…”